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433 results for Pyrrolidines+-+therapeutic+use

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ArticlesPeer ReviewedFull Text
The current landscape of nucleic acid therapeutics
Author / Creator:Kulkarni, Jayesh A. ; Witzigmann, Dominik ; Thomson, Sarah B. ; Chen, Sam ; Leavitt, Blair R. ; Cullis, Pieter R. ; van der Meel, Roy
Publisher:London: Nature Publishing Group UK
Journal title:Nature nanotechnology, 2021-06, Vol.16 (6), p.630-643
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Current and future status of JAK inhibitors
Author / Creator:McLornan, Donal P ; Pope, Janet E ; Gotlib, Jason ; Harrison, Claire N
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2021-08, Vol.398 (10302), p.803-816
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VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
Author / Creator:Keating, Dominic ; Marigowda, Gautham ; Burr, Lucy ; Daines, Cori ; Mall, Marcus A ; McKone, Edward F ; Ramsey, Bonnie W ; Rowe, Steven M ; Sass, Laura A ; Tullis, Elizabeth ; McKee, Charlotte M ; Moskowitz, Samuel M ; Robertson, Sarah ; Savage, Jessica ; Simard, Christopher ; Van Goor, Fredrick ; Waltz, David ; Xuan, Fengjuan ; Young, Tim ; Taylor-Cousar, Jennifer L
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2018-10, Vol.379 (17), p.1612-1620
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Trifluridine–Tipiracil and Bevacizumab in Refractory Metastatic Colorectal Cancer
Author / Creator:Prager, Gerald W. ; Taieb, Julien ; Fakih, Marwan ; Ciardiello, Fortunato ; Van Cutsem, Eric ; Elez, Elena ; Cruz, Felipe M. ; Wyrwicz, Lucjan ; Stroyakovskiy, Daniil ; Pápai, Zsuzsanna ; Poureau, Pierre-Guillaume ; Liposits, Gabor ; Cremolini, Chiara ; Bondarenko, Igor ; Modest, Dominik P. ; Benhadji, Karim A. ; Amellal, Nadia ; Leger, Catherine ; Vidot, Loïck ; Tabernero, Josep
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2023-05, Vol.388 (18), p.1657-1667
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Efficacy and Safety of Glecaprevir/Pibrentasvir in Patients Coinfected With Hepatitis C Virus and Human Immunodeficiency Virus Type 1: The EXPEDITION-2 Study
Author / Creator:Rockstroh, Jürgen K ; Lacombe, Karine ; Viani, Rolando M ; Orkin, Chloe ; Wyles, David ; Luetkemeyer, Anne F ; Soto-Malave, Ruth ; Flisiak, Robert ; Bhagani, Sanjay ; Sherman, Kenneth E ; Shimonova, Tatiana ; Ruane, Peter ; Sasadeusz, Joseph ; Slim, Jihad ; Zhang, Zhenzhen ; Samanta, Suvajit ; Ng, Teresa I ; Gulati, Abhishek ; Kosloski, Matthew P ; Shulman, Nancy S ; Trinh, Roger ; Sulkowski, Mark
Publisher:US: Oxford University Press
Journal title:Clinical infectious diseases, 2018-09, Vol.67 (7), p.1010-1017
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VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
Author / Creator:Davies, Jane C ; Moskowitz, Samuel M ; Brown, Cynthia ; Horsley, Alexander ; Mall, Marcus A ; McKone, Edward F ; Plant, Barry J ; Prais, Dario ; Ramsey, Bonnie W ; Taylor-Cousar, Jennifer L ; Tullis, Elizabeth ; Uluer, Ahmet ; McKee, Charlotte M ; Robertson, Sarah ; Shilling, Rebecca A ; Simard, Christopher ; Van Goor, Fredrick ; Waltz, David ; Xuan, Fengjuan ; Young, Tim ; Rowe, Steven M
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2018-10, Vol.379 (17), p.1599-1611
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A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia
Author / Creator:Krystal, Andrew D. ; Pizzagalli, Diego A. ; Smoski, Moria ; Mathew, Sanjay J. ; Nurnberger, John ; Lisanby, Sarah H. ; Iosifescu, Dan ; Murrough, James W. ; Yang, Hongqiu ; Weiner, Richard D. ; Calabrese, Joseph R. ; Sanacora, Gerard ; Hermes, Gretchen ; Keefe, Richard S. E. ; Song, Allen ; Goodman, Wayne ; Szabo, Steven T. ; Whitton, Alexis E. ; Gao, Keming ; Potter, William Z.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2020-05, Vol.26 (5), p.760-768
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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
Author / Creator:Frost, Julianty ; Galdeano, Carles ; Soares, Pedro ; Gadd, Morgan S. ; Grzes, Katarzyna M. ; Ellis, Lucy ; Epemolu, Ola ; Shimamura, Satoko ; Bantscheff, Marcus ; Grandi, Paola ; Read, Kevin D. ; Cantrell, Doreen A. ; Rocha, Sonia ; Ciulli, Alessio
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-11, Vol.7 (1), p.13312-12, Article 13312
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ArticlesPeer ReviewedFull Text
Fedratinib, a newly approved treatment for patients with myeloproliferative neoplasm-associated myelofibrosis
Author / Creator:Talpaz, Moshe ; Kiladjian, Jean-Jacques
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-01, Vol.35 (1), p.1-17
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ArticlesPeer ReviewedFull Text
Management of myelofibrosis after ruxolitinib failure
Author / Creator:Harrison, Claire N ; Schaap, Nicolaas ; Mesa, Ruben A
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Annals of hematology, 2020-06, Vol.99 (6), p.1177-1191
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ArticlesPeer ReviewedFull Text
Daridorexant: First Approval
Author / Creator:Markham, Anthony
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2022-04, Vol.82 (5), p.601-607
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ArticlesPeer ReviewedFull Text
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection
Author / Creator:Dampalla, Chamandi S. ; Zheng, Jian ; Perera, Krishani Dinali ; Wong, Lok-Yin Roy ; Meyerholz, David K. ; Nguyen, Harry Nhat ; Kashipathy, Maithri M. ; Battaile, Kevin P. ; Lovell, Scott ; Kim, Yunjeong ; Perlman, Stanley ; Groutas, William C. ; Chang, Kyeong-Ok
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (29), p.1-8
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ArticlesPeer ReviewedFull Text
Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic du...
Author / Creator:Noel, Marcus ; O’Reilly, Eileen M. ; Wolpin, Brian M. ; Ryan, David P. ; Bullock, Andrea J. ; Britten, Carolyn D. ; Linehan, David C. ; Belt, Brian A. ; Gamelin, Eric C. ; Ganguly, Bishu ; Yin, Donghua ; Joh, Tenshang ; Jacobs, Ira A. ; Taylor, Carrie T. ; Lowery, Maeve A.
Publisher:New York: Springer US
Journal title:Investigational new drugs, 2020-06, Vol.38 (3), p.800-811
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Codon-specific KRAS mutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer
Author / Creator:van de Haar, Joris ; Ma, Xuhui ; Ooft, Salo N. ; van der Helm, Pim W. ; Hoes, Louisa R. ; Mainardi, Sara ; Pinato, David J. ; Sun, Kristi ; Salvatore, Lisa ; Tortora, Giampaolo ; Zurlo, Ina Valeria ; Leo, Silvana ; Giampieri, Riccardo ; Berardi, Rossana ; Gelsomino, Fabio ; Merz, Valeria ; Mazzuca, Federica ; Antonuzzo, Lorenzo ; Rosati, Gerardo ; Stavraka, Chara ; Ross, Paul ; Rodriquenz, Maria Grazia ; Pavarana, Michele ; Messina, Carlo ; Iveson, Timothy ; Zoratto, Federica ; Thomas, Anne ; Fenocchio, Elisabetta ; Ratti, Margherita ; Depetris, Ilaria ; Cergnul, Massimiliano ; Morelli, Cristina ; Libertini, Michela ; Parisi, Alessandro ; De Tursi, Michele ; Zanaletti, Nicoletta ; Garrone, Ornella ; Graham, Janet ; Longarini, Raffaella ; Gobba, Stefania Maria ; Petrillo, Angelica ; Tamburini, Emiliano ; La Verde, Nicla ; Petrelli, Fausto ; Ricci, Vincenzo ; Wessels, Lodewyk F. A. ; Ghidini, Michele ; Cortellini, Alessio ; Voest, Emile E. ; Valeri, Nicola
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2023-03, Vol.29 (3), p.605-614
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Eliglustat compared with imiglucerase in patients with Gaucher's disease type 1 stabilised on enzyme replacement therapy: a phase 3, randomised, open-label, non-inferiority trial
Author / Creator:Cox, Timothy M, Prof ; Drelichman, Guillermo, MD ; Cravo, Renata, MD ; Balwani, Manisha, MD ; Burrow, Thomas Andrew, MD ; Martins, Ana Maria, MD ; Lukina, Elena, Prof ; Rosenbloom, Barry, MD ; Ross, Leorah, MD ; Angell, Jennifer, MSc ; Puga, Ana Cristina, MD
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2015-06, Vol.385 (9985), p.2355-2362
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ArticlesPeer ReviewedFull Text
Dynorphin, Dysphoria, and Dependence: the Stress of Addiction
Author / Creator:Chavkin, Charles ; Koob, George F
Publisher:England: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2016-01, Vol.41 (1), p.373-374
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ArticlesPeer ReviewedFull Text
Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of dipeptidyl peptidase-IV inhibition
Author / Creator:ROSARIA RIZZO, Maria ; BARBIERI, Michelangela ; MARFELLA, Raffaele ; PAOLISSO, Giuseppe
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes care, 2012-10, Vol.35 (10), p.2076-2082
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DPP-4 inhibitors: impact on glycemic control and cardiovascular risk factors
Author / Creator:Dicker, Dror
Publisher:United States: American Diabetes Association
Journal title:Diabetes care, 2011-05, Vol.34 Suppl 2 (5), p.S276-S278
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ArticlesPeer ReviewedFull Text
MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer
Author / Creator:Tisato, Veronica ; Voltan, Rebecca ; Gonelli, Arianna ; Secchiero, Paola ; Zauli, Giorgio
Publisher:England: BioMed Central Ltd
Journal title:Journal of hematology and oncology, 2017-07, Vol.10 (1), p.133-133, Article 133
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ArticlesPeer ReviewedFull Text
Synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles: a review of the literature from 2000-2012
Author / Creator:de Oliveira, Cledualdo Soares ; Lira, Bruno Freitas ; Barbosa-Filho, José Maria ; Lorenzo, Jorge Gonçalo Fernandez ; de Athayde-Filho, Petrônio Filgueiras
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2012-08, Vol.17 (9), p.10192-10231
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Showing 1 to 20 of 433 results

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The current landscape of nucleic acid therapeutics

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Current and future status of JAK inhibitors

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VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

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Trifluridine–Tipiracil and Bevacizumab in Refractory Metastatic Colorectal Cancer

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Efficacy and Safety of Glecaprevir/Pibrentasvir in Patients Coinfected With Hepatitis C Virus and Human Immunodeficiency Virus Type 1: The EXPEDITION-2 Study

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VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

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A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia

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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

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Fedratinib, a newly approved treatment for patients with myeloproliferative neoplasm-associated myelofibrosis

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Management of myelofibrosis after ruxolitinib failure

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Daridorexant: First Approval

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Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

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Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic du...

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Codon-specific KRAS mutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer

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Eliglustat compared with imiglucerase in patients with Gaucher's disease type 1 stabilised on enzyme replacement therapy: a phase 3, randomised, open-label, non-inferiority trial

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Dynorphin, Dysphoria, and Dependence: the Stress of Addiction

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Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of dipeptidyl peptidase-IV inhibition

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DPP-4 inhibitors: impact on glycemic control and cardiovascular risk factors

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MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer

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Synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles: a review of the literature from 2000-2012

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