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Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial
Author / Creator:Wu, Yi-Long ; Cheng, Ying ; Zhou, Xiangdong ; Lee, Ki Hyeong ; Nakagawa, Kazuhiko ; Niho, Seiji ; Tsuji, Fumito ; Linke, Rolf ; Rosell, Rafael ; Corral, Jesus ; Migliorino, Maria Rita ; Pluzanski, Adam ; Sbar, Eric I ; Wang, Tao ; White, Jane Liang ; Nadanaciva, Sashi ; Sandin, Rickard ; Mok, Tony S
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2017-11, Vol.18 (11), p.1454-1466
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Osimertinib in Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer
Author / Creator:Soria, Jean-Charles ; Ohe, Yuichiro ; Vansteenkiste, Johan ; Reungwetwattana, Thanyanan ; Chewaskulyong, Busyamas ; Lee, Ki Hyeong ; Dechaphunkul, Arunee ; Imamura, Fumio ; Nogami, Naoyuki ; Kurata, Takayasu ; Okamoto, Isamu ; Zhou, Caicun ; Cho, Byoung Chul ; Cheng, Ying ; Cho, Eun Kyung ; Voon, Pei Jye ; Planchard, David ; Su, Wu-Chou ; Gray, Jhanelle E ; Lee, Siow-Ming ; Hodge, Rachel ; Marotti, Marcelo ; Rukazenkov, Yuri ; Ramalingam, Suresh S
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2018-01, Vol.378 (2), p.113-125
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Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation
Author / Creator:Marty, Francisco M ; Ljungman, Per ; Chemaly, Roy F ; Maertens, Johan ; Dadwal, Sanjeet S ; Duarte, Rafael F ; Haider, Shariq ; Ullmann, Andrew J ; Katayama, Yuta ; Brown, Janice ; Mullane, Kathleen M ; Boeckh, Michael ; Blumberg, Emily A ; Einsele, Hermann ; Snydman, David R ; Kanda, Yoshinobu ; DiNubile, Mark J ; Teal, Valerie L ; Wan, Hong ; Murata, Yoshihiko ; Kartsonis, Nicholas A ; Leavitt, Randi Y ; Badshah, Cyrus
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2017-12, Vol.377 (25), p.2433-2444
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Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials
Author / Creator:Yang, James Chih-Hsin, Prof ; Wu, Yi-Long, Prof ; Schuler, Martin, Prof ; Sebastian, Martin, MD ; Popat, Sanjay, FRCP ; Yamamoto, Nobuyuki, Prof ; Zhou, Caicun, Prof ; Hu, Cheng-Ping, Prof ; O'Byrne, Kenneth, Prof ; Feng, Jifeng, Prof ; Lu, Shun, Prof ; Huang, Yunchao, Prof ; Geater, Sarayut L, MD ; Lee, Kye Young, Prof ; Tsai, Chun-Ming, Prof ; Gorbunova, Vera, Prof ; Hirsh, Vera, Prof ; Bennouna, Jaafar, Prof ; Orlov, Sergey, Prof ; Mok, Tony, Prof ; Boyer, Michael, Prof ; Su, Wu-Chou, Prof ; Lee, Ki Hyeong, Prof ; Kato, Terufumi, MD ; Massey, Dan, MSc ; Shahidi, Mehdi, MD ; Zazulina, Victoria, MD ; Sequist, Lecia V, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2015-02, Vol.16 (2), p.141-151
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Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/...
Author / Creator:Miller, Vincent A, Prof ; Hirsh, Vera, MD ; Cadranel, Jacques, Prof ; Chen, Yuh-Min, MD ; Park, Keunchil, Prof ; Kim, Sang-We, Prof ; Zhou, Caicun, Prof ; Su, Wu-Chou, Prof ; Wang, Mengzhao, Prof ; Sun, Yan, Prof ; Heo, Dae Seog, Prof ; Crino, Lucio, Prof ; Tan, Eng-Huat, MD ; Chao, Tsu-Yi, Prof ; Shahidi, Mehdi, MD ; Cong, Xiuyu Julie, PhD ; Lorence, Robert M, MD ; Yang, James Chih-Hsin, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2012-05, Vol.13 (5), p.528-538
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Phase 3 Trial of Selpercatinib in Advanced RET-Mutant Medullary Thyroid Cancer
Author / Creator:Hadoux, Julien ; Elisei, Rossella ; Brose, Marcia S. ; Hoff, Ana O. ; Robinson, Bruce G. ; Gao, Ming ; Jarzab, Barbara ; Isaev, Pavel ; Kopeckova, Katerina ; Wadsley, Jonathan ; Führer, Dagmar ; Keam, Bhumsuk ; Bardet, Stéphane ; Sherman, Eric J. ; Tahara, Makoto ; Hu, Mimi I. ; Singh, Ravinder ; Lin, Yan ; Soldatenkova, Victoria ; Wright, Jennifer ; Lin, Boris ; Maeda, Patricia ; Capdevila, Jaume ; Wirth, Lori J.
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2023-11, Vol.389 (20), p.1851-1861
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Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial
Author / Creator:Soria, Jean-Charles, Prof ; Felip, Enriqueta, MD ; Cobo, Manuel, MD ; Lu, Shun, MD ; Syrigos, Konstantinos, Prof ; Lee, Ki Hyeong, MD ; Göker, Erdem, MD ; Georgoulias, Vassilis, Prof ; Li, Wei, MD ; Isla, Dolores, MD ; Guclu, Salih Z, MD ; Morabito, Alessandro, MD ; Min, Young J, MD ; Ardizzoni, Andrea, MD ; Gadgeel, Shirish M, Prof ; Wang, Bushi, PhD ; Chand, Vikram K, MD ; Goss, Glenwood D, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2015-08, Vol.16 (8), p.897-907
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ArticlesPeer ReviewedFull Text
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
Author / Creator:Li, Chia-Wei ; Lim, Seung-Oe ; Xia, Weiya ; Lee, Heng-Huan ; Chan, Li-Chuan ; Kuo, Chu-Wei ; Khoo, Kay-Hooi ; Chang, Shih-Shin ; Cha, Jong-Ho ; Kim, Taewan ; Hsu, Jennifer L. ; Wu, Yun ; Hsu, Jung-Mao ; Yamaguchi, Hirohito ; Ding, Qingqing ; Wang, Yan ; Yao, Jun ; Lee, Cheng-Chung ; Wu, Hsing-Ju ; Sahin, Aysegul A. ; Allison, James P. ; Yu, Dihua ; Hortobagyi, Gabriel N. ; Hung, Mien-Chie
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-08, Vol.7 (1), p.12632-11, Article 12632
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Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3...
Author / Creator:Zhou, Caicun, Prof ; Wu, Yi-Long, Prof ; Chen, Gongyan, Prof ; Feng, Jifeng, Prof ; Liu, Xiao-Qing, Prof ; Wang, Changli, Prof ; Zhang, Shucai, Prof ; Wang, Jie, Prof ; Zhou, Songwen, MD ; Ren, Shengxiang, MD ; Lu, Shun, Prof ; Zhang, Li, Prof ; Hu, Chengping, Prof ; Hu, Chunhong, Prof ; Luo, Yi, Prof ; Chen, Lei, Prof ; Ye, Ming, Prof ; Huang, Jianan, Prof ; Zhi, Xiuyi, Prof ; Zhang, Yiping, Prof ; Xiu, Qingyu, Prof ; Ma, Jun, Prof ; You, Changxuan, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2011-08, Vol.12 (8), p.735-742
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Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer
Author / Creator:Robichaux, Jacqulyne P. ; Elamin, Yasir Y. ; Tan, Zhi ; Carter, Brett W. ; Zhang, Shuxing ; Liu, Shengwu ; Li, Shuai ; Chen, Ting ; Poteete, Alissa ; Estrada-Bernal, Adriana ; Le, Anh T. ; Truini, Anna ; Nilsson, Monique B. ; Sun, Huiying ; Roarty, Emily ; Goldberg, Sarah B. ; Brahmer, Julie R. ; Altan, Mehmet ; Lu, Charles ; Papadimitrakopoulou, Vassiliki ; Politi, Katerina ; Doebele, Robert C. ; Wong, Kwok-Kin ; Heymach, John V.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2018-05, Vol.24 (5), p.638-646
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Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer
Author / Creator:Tan, Chee-Seng, MRCP ; Gilligan, David, FRCPE ; Pacey, Simon, Dr
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2015-09, Vol.16 (9), p.e447-e459
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ArticlesPeer ReviewedFull Text
Antiangiogenic therapy in oncology: current status and future directions
Author / Creator:Jayson, Gordon C, Prof ; Kerbel, Robert, Prof ; Ellis, Lee M, Prof ; Harris, Adrian L, Prof
Publisher:England: Elsevier Ltd
Journal title:The Lancet (British edition), 2016-07, Vol.388 (10043), p.518-529
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Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial
Author / Creator:Yang, James Chih-Hsin, Prof ; Shih, Jin-Yuan, MD ; Su, Wu-Chou, Prof ; Hsia, Te-Chun, MD ; Tsai, Chun-Ming, Prof ; Ou, Sai-Hong Ignatius, MD ; Yu, Chung-Jen, Prof ; Chang, Gee-Chen, MD ; Ho, Ching-Liang, MD ; Sequist, Lecia V, MD ; Dudek, Arkadiusz Z, MD ; Shahidi, Mehdi, MD ; Cong, Xiuyu Julie, PhD ; Lorence, Robert M, MD ; Yang, Pan-Chyr, Prof ; Miller, Vincent A, Dr
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2012-05, Vol.13 (5), p.539-548
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Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): survival outcomes of a randomised, open-label, multicentre, phase 3 trial and their association with pathological complete...
Author / Creator:de Azambuja, Evandro, Dr ; Holmes, Andrew P, PhD ; Piccart-Gebhart, Martine, MD ; Holmes, Eileen, PhD ; Di Cosimo, Serena, MD ; Swaby, Ramona F, MD ; Untch, Michael, MD ; Jackisch, Christian, MD ; Lang, Istvan, MD ; Smith, Ian, MD ; Boyle, Frances, MBBS ; Xu, Binghe, MD ; Barrios, Carlos H, MD ; Perez, Edith A, MD ; Azim, Hatem A, MD ; Kim, Sung-Bae, MD ; Kuemmel, Sherko, MD ; Huang, Chiun-Sheng, MD ; Vuylsteke, Peter, MD ; Hsieh, Ruey-Kuen, MD ; Gorbunova, Vera, MD ; Eniu, Alexandru, MD ; Dreosti, Lydia, MD ; Tavartkiladze, Natalia, MD ; Gelber, Richard D, PhD ; Eidtmann, Holger, MD ; Baselga, José, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2014-09, Vol.15 (10), p.1137-1146
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Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA
Author / Creator:Nathanson, David A. ; Gini, Beatrice ; Mottahedeh, Jack ; Visnyei, Koppany ; Koga, Tomoyuki ; Gomez, German ; Estin, Ascia ; Hwang, Kiwook ; Wang, Jun ; Masui, Kenta ; Paucar, Andres ; Yang, Huijun ; Ohashi, Minori ; Zhu, Shaojun ; Wykosky, Jill ; Reed, Rachel ; Nelson, Stanley F. ; Cloughesy, Timothy F. ; James, C. David ; Rao, P. Nagesh ; Kornblum, Harley I. ; Heath, James R. ; Cavenee, Webster K. ; Furnari, Frank B. ; Mischel, Paul S.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2014-01, Vol.343 (6166), p.72-76
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ArticlesPeer ReviewedFull Text
Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3...
Author / Creator:Wu, Yi-Long, Prof ; Zhou, Caicun, Prof ; Hu, Cheng-Ping, Prof ; Feng, Jifeng, Prof ; Lu, Shun, Prof ; Huang, Yunchao, Prof ; Li, Wei, Prof ; Hou, Mei, Prof ; Shi, Jian Hua, Prof ; Lee, Kye Young, Prof ; Xu, Chong-Rui, MD ; Massey, Dan, MSc ; Kim, Miyoung, MD ; Shi, Yang, MD ; Geater, Sarayut L, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2014-02, Vol.15 (2), p.213-222
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Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial
Author / Creator:Garassino, Marina Chiara, MD ; Martelli, Olga, MD ; Broggini, Massimo, PhD ; Farina, Gabriella, MD ; Veronese, Silvio, PhD ; Rulli, Eliana, PhD ; Bianchi, Filippo, MD ; Bettini, Anna, MD ; Longo, Flavia, MD ; Moscetti, Luca, MD ; Tomirotti, Maurizio, MD ; Marabese, Mirko, PhD ; Ganzinelli, Monica, PhD ; Lauricella, Calogero, PhD ; Labianca, Roberto, MD ; Floriani, Irene, PhD ; Giaccone, Giuseppe, MD ; Torri, Valter, MD ; Scanni, Alberto, MD ; Marsoni, Silvia, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2013-09, Vol.14 (10), p.981-988
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Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial
Author / Creator:Shi, Yuankai, MD ; Zhang, Li, MD ; Liu, Xiaoqing, MD ; Zhou, Caicun, MD ; Zhang, Shucai, MD ; Wang, Dong, MD ; Li, Qiang, MD ; Qin, Shukui, MD ; Hu, Chunhong, MD ; Zhang, Yiping, MD ; Chen, Jianhua, MD ; Cheng, Ying, MD ; Feng, Jifeng, MD ; Zhang, Helong, MD ; Song, Yong, MD ; Wu, Yi-Long, MD ; Xu, Nong, MD ; Zhou, Jianying, MD ; Luo, Rongcheng, MD ; Bai, Chunxue, MD ; Jin, Yening, MD ; Liu, Wenchao, MD ; Wei, Zhaohui, PhD ; Tan, Fenlai, MD ; Wang, Yinxiang, PhD ; Ding, Lieming, MD ; Dai, Hong, MD ; Jiao, Shunchang, MD ; Wang, Jie, MD ; Liang, Li, MD ; Zhang, Weimin, MD ; Sun, Yan, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2013-09, Vol.14 (10), p.953-961
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A phase III randomised controlled trial of erlotinib vs gefitinib in advanced non-small cell lung cancer with EGFR mutations
Author / Creator:Yang, J J ; Zhou, Q ; Yan, H H ; Zhang, X C ; Chen, H J ; Tu, H Y ; Wang, Z ; Xu, C R ; Su, J ; Wang, B C ; Jiang, B Y ; Bai, X Y ; Zhong, W Z ; Yang, X N ; Wu, Y L
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2017-02, Vol.116 (5), p.568-574
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Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial
Author / Creator:Dutton, Susan J, MSc ; Ferry, David R, Prof ; Blazeby, Jane M, Prof ; Abbas, Haider, MRCP ; Dahle-Smith, Asa, MBChB ; Mansoor, Wasat, PhD ; Thompson, Joyce, FRCP ; Harrison, Mark, PhD ; Chatterjee, Anirban, FRCR ; Falk, Stephen, MD ; Garcia-Alonso, Angel, MD ; Fyfe, David W, MD ; Hubner, Richard A, PhD ; Gamble, Tina ; Peachey, Lynnda, BSc ; Davoudianfar, Mina, BA ; Pearson, Sarah R, BSc ; Julier, Patrick, MSc ; Jankowski, Janusz, Prof ; Kerr, Rachel, MD ; Petty, Russell D, MRCP
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2014-07, Vol.15 (8), p.894-904
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Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial

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Osimertinib in Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer

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Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation

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Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials

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Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/...

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Phase 3 Trial of Selpercatinib in Advanced RET-Mutant Medullary Thyroid Cancer

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Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial

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Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

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Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3...

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Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer

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Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer

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Antiangiogenic therapy in oncology: current status and future directions

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Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial

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Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): survival outcomes of a randomised, open-label, multicentre, phase 3 trial and their association with pathological complete...

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Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

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Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3...

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Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial

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Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial

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A phase III randomised controlled trial of erlotinib vs gefitinib in advanced non-small cell lung cancer with EGFR mutations

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Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial

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