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65 results for Receptor,+Insulin+-+antagonists+

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ArticlesPeer ReviewedFull Text
Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents
Author / Creator:Scarlett, Jarrad M ; Rojas, Jennifer M ; Matsen, Miles E ; Kaiyala, Karl J ; Stefanovski, Darko ; Bergman, Richard N ; Nguyen, Hong T ; Dorfman, Mauricio D ; Lantier, Louise ; Wasserman, David H ; Mirzadeh, Zaman ; Unterman, Terry G ; Morton, Gregory J ; Schwartz, Michael W
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2016-07, Vol.22 (7), p.800-806
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Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting
Author / Creator:YANG JIAO ; LE LAY, John ; MING YU ; NAJI, Ali ; KAESTNER, Klaus H
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2014-04, Vol.63 (4), p.1283-1288
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Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity
Author / Creator:Kleiner, Sandra ; Gomez, Daniel ; Megra, Bezawit ; Na, Erqian ; Bhavsar, Ramandeep ; Cavino, Katie ; Xin, Yurong ; Rojas, Jose ; Dominguez-Gutierrez, Giselle ; Zambrowicz, Brian ; Carrat, Gaelle ; Chabosseau, Pauline ; Hu, Ming ; Murphy, Andrew J. ; Yancopoulos, George D. ; Rutter, Guy A. ; Gromada, Jesper
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (32), p.E7642-E7649
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A homeostatic gut-to-brain insulin antagonist restrains neuronally stimulated fat loss
Author / Creator:Liu, Chung-Chih ; Khan, Ayub ; Seban, Nicolas ; Littlejohn, Nicole ; Shah, Aayushi ; Srinivasan, Supriya
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-08, Vol.15 (1), p.6869-16, Article 6869
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Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization
Author / Creator:Martín‐Segura, Adrián ; Ahmed, Tariq ; Casadomé‐Perales, Álvaro ; Palomares‐Perez, Irene ; Palomer, Ernest ; Kerstens, Axelle ; Munck, Sebastian ; Balschun, Detlef ; Dotti, Carlos G.
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2019-06, Vol.18 (3), p.e12932-n/a
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Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice
Author / Creator:Ai, Ding ; Chen, Chiyuan ; Han, Seongah ; Ganda, Anjali ; Murphy, Andrew J ; Haeusler, Rebecca ; Thorp, Edward ; Accili, Domenico ; Horton, Jay D ; Tall, Alan R
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2012-04, Vol.122 (4), p.1262-1270
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Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway
Author / Creator:Shirakawa, Jun ; Tajima, Kazuki ; Okuyama, Tomoko ; Kyohara, Mayu ; Togashi, Yu ; De Jesus, Dario F. ; Basile, Giorgio ; Kin, Tatsuya ; Shapiro, A. M. James ; Kulkarni, Rohit N. ; Terauchi, Yasuo
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2020-03, Vol.63 (3), p.577-587
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Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer’s Disease-like Neurotoxicity
Author / Creator:Wang, Tingwei ; Xie, Cuiwei ; Yu, Pengfei ; Fang, Fangfang ; Zhu, Jingying ; Cheng, Jie ; Gu, Aihua ; Wang, Jun ; Xiao, Hang
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-08, Vol.7 (1), p.7497-12, Article 7497
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Feeding regulates sex pheromone attraction and courtship in Drosophila females
Author / Creator:Lebreton, Sébastien ; Trona, Federica ; Borrero-Echeverry, Felipe ; Bilz, Florian ; Grabe, Veit ; Becher, Paul G. ; Carlsson, Mikael A. ; Nässel, Dick R. ; Hansson, Bill S. ; Sachse, Silke ; Witzgall, Peter
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2015-08, Vol.5 (1), p.13132-13132, Article 13132
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ArticlesPeer ReviewedFull Text
Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor
Author / Creator:Okuyama, Tomoko ; Shirakawa, Jun ; Tajima, Kazuki ; Ino, Yoko ; Vethe, Heidrun ; Togashi, Yu ; Kyohara, Mayu ; Inoue, Ryota ; Miyashita, Daisuke ; Li, Jinghe ; Goto, Nozomi ; Ichikawa, Taiga ; Yamasaki, Shingo ; Ohnuma, Haruka ; Takayanagi, Rie ; Kimura, Yayoi ; Hirano, Hisashi ; Terauchi, Yasuo
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-10, Vol.21 (21), p.7815
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Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation
Author / Creator:Fox, Emily M ; Kuba, María Gabriela ; Miller, Todd W ; Davies, Barry R ; Arteaga, Carlos L
Publisher:England: BioMed Central Ltd
Journal title:Breast cancer research : BCR, 2013-01, Vol.15 (4), p.R55-R55, Article R55
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Disruption of insulin receptor function inhibits proliferation in endocrine-resistant breast cancer cells
Author / Creator:Chan, J Y ; LaPara, K ; Yee, D
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2016-08, Vol.35 (32), p.4235-4243
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ArticlesPeer ReviewedFull Text
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
Author / Creator:Obici, Silvana ; Feng, Zhaohui ; Karkanias, George ; Baskin, Denis G. ; Rossetti, Luciano
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2002-06, Vol.5 (6), p.566-572
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Starvation increases insulin sensitivity and reduces juvenile hormone synthesis in mosquitoes
Author / Creator:Perez-Hedo, Meritxell ; Rivera-Perez, Crisalejandra ; Noriega, Fernando G
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-01, Vol.9 (1), p.e86183-e86183
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Structural biology of insulin and IGF1 receptors: implications for drug design
Author / Creator:De Meyts, Pierre ; Whittaker, Jonathan
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2002-10, Vol.1 (10), p.769-783
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Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation
Author / Creator:Zhang, H ; Fagan, D H ; Zeng, X ; Freeman, K T ; Sachdev, D ; Yee, D
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2010-04, Vol.29 (17), p.2517-2527
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Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice
Author / Creator:KLOVER, Peter J ; ZIMMERS, Teresa A ; KONIARIS, Leonidas G ; MOONEY, Robert A
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2003-11, Vol.52 (11), p.2784-2789
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ArticlesPeer ReviewedFull Text
Juxtamembrane autoinhibition in receptor tyrosine kinases
Author / Creator:Hubbard, Stevan R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Molecular cell biology, 2004-06, Vol.5 (6), p.464-471
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Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism
Author / Creator:Stout, Gerdine J ; Stigter, Edwin C A ; Essers, Paul B ; Mulder, Klaas W ; Kolkman, Annemieke ; Snijders, Dorien S ; van den Broek, Niels J F ; Betist, Marco C ; Korswagen, Hendrik C ; MacInnes, Alyson W ; Brenkman, Arjan B
Publisher:London: Nature Publishing Group UK
Journal title:Molecular systems biology, 2013-07, Vol.9 (1), p.679-n/a
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Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?
Author / Creator:Wulf Dröge
Publisher:London: The Royal Society
Journal title:Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2005-12, Vol.360 (1464), p.2355-2372
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Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents

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Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting

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Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity

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A homeostatic gut-to-brain insulin antagonist restrains neuronally stimulated fat loss

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Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization

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Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice

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Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway

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Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer’s Disease-like Neurotoxicity

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Feeding regulates sex pheromone attraction and courtship in Drosophila females

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Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor

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Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation

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Disruption of insulin receptor function inhibits proliferation in endocrine-resistant breast cancer cells

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Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

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Starvation increases insulin sensitivity and reduces juvenile hormone synthesis in mosquitoes

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Structural biology of insulin and IGF1 receptors: implications for drug design

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Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation

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Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice

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Juxtamembrane autoinhibition in receptor tyrosine kinases

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Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism

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Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?

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