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ArticlesPeer ReviewedFull Text
Vorapaxar in the Secondary Prevention of Atherothrombotic Events
Author / Creator:Morrow, David A ; Braunwald, Eugene ; Bonaca, Marc P ; Ameriso, Sebastian F ; Dalby, Anthony J ; Fish, Mary Polly ; Fox, Keith A.A ; Lipka, Leslie J ; Liu, Xuan ; Nicolau, José Carlos ; Ophuis, A.J. Oude ; Paolasso, Ernesto ; Scirica, Benjamin M ; Spinar, Jindrich ; Theroux, Pierre ; Wiviott, Stephen D ; Strony, John ; Murphy, Sabina A
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2012-04, Vol.366 (15), p.1404-1413
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High-resolution crystal structure of human protease-activated receptor 1
Author / Creator:Zhang, Cheng ; Srinivasan, Yoga ; Arlow, Daniel H. ; Fung, Juan Jose ; Palmer, Daniel ; Zheng, Yaowu ; Green, Hillary F. ; Pandey, Anjali ; Dror, Ron O. ; Shaw, David E. ; Weis, William I. ; Coughlin, Shaun R. ; Kobilka, Brian K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2012-12, Vol.492 (7429), p.387-392
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Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes
Author / Creator:Tricoci, Pierluigi ; Huang, Zhen ; Held, Claes ; Moliterno, David J ; Armstrong, Paul W ; Van de Werf, Frans ; White, Harvey D ; Aylward, Philip E ; Wallentin, Lars ; Chen, Edmond ; Lokhnygina, Yuliya ; Pei, Jinglan ; Leonardi, Sergio ; Rorick, Tyrus L ; Kilian, Ann M ; Jennings, Lisa H.K ; Ambrosio, Giuseppe ; Bode, Christoph ; Cequier, Angel ; Cornel, Jan H ; Diaz, Rafael ; Erkan, Aycan ; Huber, Kurt ; Hudson, Michael P ; Jiang, Lixin ; Jukema, J. Wouter ; Lewis, Basil S ; Lincoff, A. Michael ; Montalescot, Gilles ; Nicolau, José Carlos ; Ogawa, Hisao ; Pfisterer, Matthias ; Prieto, Juan Carlos ; Ruzyllo, Witold ; Sinnaeve, Peter R ; Storey, Robert F ; Valgimigli, Marco ; Whellan, David J ; Widimsky, Petr ; Strony, John ; Harrington, Robert A ; Mahaffey, Kenneth W
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2012-01, Vol.366 (1), p.20-33
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Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial
Author / Creator:Scirica, Benjamin M, Dr ; Bonaca, Marc P, MD ; Braunwald, Eugene, Prof ; De Ferrari, Gaetano M, MD ; Isaza, Daniel, MD ; Lewis, Basil S, Prof ; Mehrhof, Felix, MD ; Merlini, Piera A, Prof ; Murphy, Sabina A, MPH ; Sabatine, Marc S, MD ; Tendera, Michal, Prof ; Van de Werf, Frans, Prof ; Wilcox, Robert, Prof ; Morrow, David A, MD
Publisher:Kidlington: Elsevier Ltd
Journal title:The Lancet (British edition), 2012-10, Vol.380 (9850), p.1317-1324
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Hydrocephalus after Intraventricular Hemorrhage: The Role of Thrombin
Author / Creator:Gao, Feng ; Liu, Fuyi ; Chen, Zhi ; Hua, Ya ; Keep, Richard F ; Xi, Guohua
Publisher:London, England: SAGE Publications
Journal title:Journal of cerebral blood flow and metabolism, 2014-03, Vol.34 (3), p.489-494
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Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin-Receptor Antagonist in Secondary Preventi...
Author / Creator:Morrow, David A., MD, MPH ; Scirica, Benjamin M., MD, MPH ; Fox, Keith A.A., MD ; Berman, Gail, MD ; Strony, John, MD ; Veltri, Enrico, MD ; Bonaca, Marc P., MD ; Fish, Polly, BA ; McCabe, Carolyn H., BS ; Braunwald, Eugene, MD
Publisher:United States: Mosby, Inc
Journal title:The American heart journal, 2009-09, Vol.158 (3), p.335-341.e3
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Coagulation Signaling through PAR1 as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma
Author / Creator:Kothari, Aditi ; Flick, Matthew J.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-05, Vol.22 (10), p.5138
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The Inflammatory Actions of Coagulant and Fibrinolytic Proteases in Disease
Author / Creator:Schuliga, Michael
Publisher:Cairo, Egypt: Hindawi Limiteds
Journal title:Mediators of Inflammation, 2015-01, Vol.2015 (2015), p.108-116-209
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Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation
Author / Creator:Niessen, Frank ; Schaffner, Florence ; Furlan-Freguia, Christian ; Pawlinski, Rafal ; Bhattacharjee, Gourab ; Chun, Jerold ; Derian, Claudia K. ; Andrade-Gordon, Patricia ; Rosen, Hugh ; Ruf, Wolfram
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2008-04, Vol.452 (7187), p.654-658
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PARIN5, a Novel Thrombin Receptor Antagonist Modulates a Streptozotocin Mice Model for Diabetic Encephalopathy
Author / Creator:Golderman, Valery ; Goldberg, Zehavit ; Gofrit, Shany Guly ; Dori, Amir ; Maggio, Nicola ; Chapman, Joab ; Sher, Ifat ; Rotenstreich, Ygal ; Shavit-Stein, Efrat
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2023-01, Vol.24 (3), p.2021
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pHLIP(Var7)-P1AP suppresses tumor cell proliferation in MDA-MB-231 triple-negative breast cancer by targeting protease activated receptor 1
Author / Creator:Yu, MingMing ; Chen, YueHua ; Wang, ZhenGuang ; Ding, XiaoDong
Publisher:New York: Springer US
Journal title:Breast cancer research and treatment, 2020-04, Vol.180 (2), p.379-384
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PAR1 contributes to influenza A virus pathogenicity in mice
Author / Creator:Khoufache, Khaled ; Berri, Fatma ; Nacken, Wolfgang ; Vogel, Annette B. ; Delenne, Marie ; Camerer, Eric ; Coughlin, Shaun R. ; Carmeliet, Peter ; Lina, Bruno ; Rimmelzwaan, Guus F. ; Planz, Oliver ; Ludwig, Stephan ; Riteau, Béatrice
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2013-01, Vol.123 (1), p.206-214
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Pharmacodynamics and pharmacokinetics of the novel PAR-1 antagonist vorapaxar (formerly SCH 530348) in healthy subjects
Author / Creator:Kosoglou, Teddy ; Reyderman, Larisa ; Tiessen, Renger G. ; van Vliet, André A. ; Fales, Robert R. ; Keller, Robert ; Yang, Bo ; Cutler, David L.
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:European journal of clinical pharmacology, 2012-03, Vol.68 (3), p.249-258
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Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?
Author / Creator:Chambers, R C
Publisher:Oxford, UK: Blackwell Publishing Ltd
Journal title:British journal of pharmacology, 2008-03, Vol.153 (S1), p.S367-S378
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Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis
Author / Creator:Lin, Cong ; Duitman, JanWillem ; Daalhuisen, Joost ; ten Brink, Marieke ; von der Thüsen, Jan ; van der Poll, Tom ; Borensztajn, Keren ; Spek, C Arnold
Publisher:England: BMJ Publishing Group LTD
Journal title:Thorax, 2014-02, Vol.69 (2), p.152-160
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A KLK4 proteinase substrate capture approach to antagonize PAR1
Author / Creator:Rabinovitch, Eitan ; Mihara, Koishiro ; Sananes, Amiram ; Zaretsky, Marianna ; Heyne, Michael ; Shifman, Julia ; Aharoni, Amir ; Hollenberg, Morley D. ; Papo, Niv
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-08, Vol.11 (1), p.16170-13, Article 16170
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Baicalin Protects against Thrombin-Induced Cell Injury in Human Umbilical Vein Endothelial Cells
Author / Creator:Zhou, Qingbo ; Zhang, Yuan ; Sun, Yu ; Pu, Ying ; Sun, Chao ; Hou, Yunfeng ; Zhang, Anna ; Shen, Yang
Publisher:Cairo, Egypt: Hindawi Publishing Corporation
Journal title:BioMed research international, 2019, Vol.2019 (2019), p.1-8
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The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA•CER) trial: study design and rationale
Author / Creator:Committees, The TRACER Executive and Steering
Publisher:New York, NY: Mosby, Inc
Journal title:The American heart journal, 2009-09, Vol.158 (3), p.327-334.e4
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Oral Warfarin and the Thrombin Inhibitor Dabigatran Increase Blood Pressure in Rats: Hidden Danger of Anticoagulants?
Author / Creator:Ware, Kyle M. ; Vance, Jay C. ; Muni, Navin ; Hebert, Lee A. ; Satoskar, Anjali A. ; Nadasdy, Gyongyi ; Ivanov, Iouri ; Nadasdy, Tibor ; Rovin, Brad H. ; Brodsky, Sergey V.
Publisher:US: Oxford University Press
Journal title:American journal of hypertension, 2015-02, Vol.28 (2), p.182-189
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ncRuPAR inhibits gastric cancer progression by down-regulating protease-activated receptor-1
Author / Creator:Liu, Long ; Yan, Bing ; Yang, Zhihui ; Zhang, Xiaodong ; Gu, Qunhao ; Yue, Xiaoqiang
Publisher:Dordrecht: Springer Netherlands
Journal title:Tumor biology, 2014-08, Vol.35 (8), p.7821-7829
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Vorapaxar in the Secondary Prevention of Atherothrombotic Events

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High-resolution crystal structure of human protease-activated receptor 1

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Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes

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Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial

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Hydrocephalus after Intraventricular Hemorrhage: The Role of Thrombin

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Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin-Receptor Antagonist in Secondary Preventi...

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Coagulation Signaling through PAR1 as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma

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The Inflammatory Actions of Coagulant and Fibrinolytic Proteases in Disease

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Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

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PARIN5, a Novel Thrombin Receptor Antagonist Modulates a Streptozotocin Mice Model for Diabetic Encephalopathy

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pHLIP(Var7)-P1AP suppresses tumor cell proliferation in MDA-MB-231 triple-negative breast cancer by targeting protease activated receptor 1

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PAR1 contributes to influenza A virus pathogenicity in mice

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Pharmacodynamics and pharmacokinetics of the novel PAR-1 antagonist vorapaxar (formerly SCH 530348) in healthy subjects

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Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?

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Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis

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A KLK4 proteinase substrate capture approach to antagonize PAR1

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Baicalin Protects against Thrombin-Induced Cell Injury in Human Umbilical Vein Endothelial Cells

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The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA•CER) trial: study design and rationale

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Oral Warfarin and the Thrombin Inhibitor Dabigatran Increase Blood Pressure in Rats: Hidden Danger of Anticoagulants?

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ncRuPAR inhibits gastric cancer progression by down-regulating protease-activated receptor-1

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