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Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition
Author / Creator:Wong, Gabrielle S. ; Zhou, Jin ; Liu, Jie Bin ; Wu, Zhong ; Xu, Xinsen ; Li, Tianxia ; Xu, David ; Schumacher, Steven E. ; Puschhof, Jens ; McFarland, James ; Zou, Charles ; Dulak, Austin ; Henderson, Les ; Xu, Peng ; O’Day, Emily ; Rendak, Rachel ; Liao, Wei-li ; Cecchi, Fabiola ; Hembrough, Todd ; Schwartz, Sarit ; Szeto, Christopher ; Rustgi, Anil K. ; Wong, Kwok-Kin ; Diehl, J. Alan ; Jensen, Karin ; Graziano, Francesco ; Ruzzo, Annamaria ; Fereshetian, Shaunt ; Mertins, Philipp ; Carr, Steven A. ; Beroukhim, Rameen ; Nakamura, Kenichi ; Oki, Eiji ; Watanabe, Masayuki ; Baba, Hideo ; Imamura, Yu ; Catenacci, Daniel ; Bass, Adam J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2018-07, Vol.24 (7), p.968-977
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KRAS4A and KRAS4B in liquid biopsy of metastatic lung adenocarcinoma patients treated with Pembrolizumab or chemotherapy plus Pembrolizumab
Author / Creator:Chiari, Rita ; Palladino, Silvia ; Emili, Rita ; De Lisa, Mariagrazia ; Sarti, Donatella ; Catalano, Vincenzo ; Magnani, Mauro ; Graziano, Francesco ; Ruzzo, Annamaria
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-11, Vol.13 (1), p.21036-21036, Article 21036
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XRCC1 399GG genotype predicts significantly longer overall survival in resistant lymphoma patients treated with Benda-EAM and ASCT
Author / Creator:Visani, Giuseppe ; Loscocco, Federica ; Bagaloni, Irene ; Ruzzo, Annamaria ; Fuligni, Fabio ; Graziano, Francesco ; Magnani, Mauro ; Isidori, Alessandro
Publisher:London: Nature Publishing Group UK
Journal title:Bone marrow transplantation (Basingstoke), 2020-04, Vol.55 (4), p.818-820
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Prospective validation of candidate SNPs of VEGF/VEGFR pathway in metastatic colorectal cancer patients treated with first-line FOLFIRI plus bevacizumab
Author / Creator:Loupakis, Fotios ; Cremolini, Chiara ; Yang, Dongyun ; Salvatore, Lisa ; Zhang, Wu ; Wakatsuki, Takeru ; Bohanes, Pierre ; Schirripa, Marta ; Benhaim, Leonor ; Lonardi, Sara ; Antoniotti, Carlotta ; Aprile, Giuseppe ; Graziano, Francesco ; Ruzzo, Annamaria ; Lucchesi, Sara ; Ronzoni, Monica ; De Vita, Ferdinando ; Tonini, Giuseppe ; Falcone, Alfredo ; Lenz, Heinz-Josef
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-07, Vol.8 (7), p.e66774
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Sex-Related Differences in Impact on Safety of Pharmacogenetic Profile for Colon Cancer Patients Treated with FOLFOX-4 or XELOX Adjuvant Chemotherapy
Author / Creator:Ruzzo, Annamaria ; Graziano, Francesco ; Galli, Francesca ; Galli, Fabio ; Rulli, Eliana ; Lonardi, Sara ; Ronzoni, Monica ; Massidda, Bruno ; Zagonel, Vittorina ; Pella, Nicoletta ; Mucciarini, Claudia ; Labianca, Roberto ; Ionta, Maria Teresa ; Bagaloni, Irene ; Veltri, Enzo ; Sozzi, Pietro ; Barni, Sandro ; Ricci, Vincenzo ; Foltran, Luisa ; Nicolini, Mario ; Biondi, Edoardo ; Bramati, Annalisa ; Turci, Daniele ; Lazzarelli, Silvia ; Verusio, Claudio ; Bergamo, Francesca ; Sobrero, Alberto ; Frontini, Luciano ; Magnani, Mauro
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-08, Vol.9 (1), p.11527, Article 11527
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Retrospective exploratory analysis of VEGF polymorphisms in the prediction of benefit from first-line FOLFIRI plus bevacizumab in metastatic colorectal cancer
Author / Creator:Loupakis, Fotios ; Ruzzo, Annamaria ; Salvatore, Lisa ; Cremolini, Chiara ; Masi, Gianluca ; Frumento, Paolo ; Schirripa, Marta ; Catalano, Vincenzo ; Galluccio, Nadia ; Canestrari, Emanuele ; Vincenzi, Bruno ; Santini, Daniele ; Bencardino, Katia ; Ricci, Vincenzo ; Manzoni, Mariangela ; Danova, Marco ; Tonini, Giuseppe ; Magnani, Mauro ; Falcone, Alfredo ; Graziano, Francesco
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2011-06, Vol.11 (1), p.247-247, Article 247
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Gender effects of single nucleotide polymorphisms and miRNAs targeting clock-genes in metastatic colorectal cancer patients (mCRC)
Author / Creator:Garufi, Carlo ; Giacomini, Elisa ; Torsello, Angela ; Sperduti, Isabella ; Melucci, Elisa ; Mottolese, Marcella ; Zeuli, Massimo ; Ettorre, Giuseppe Maria ; Ricciardi, Teresa ; Cognetti, Francesco ; Magnani, Mauro ; Ruzzo, Annamaria
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-09, Vol.6 (1), p.34006-34006, Article 34006
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Author Correction: Sex-Related Differences in Impact on Safety of Pharmacogenetic Profile for Colon Cancer Patients Treated with FOLFOX-4 or XELOX Adjuvant Chemotherapy
Author / Creator:Ruzzo, Annamaria ; Graziano, Francesco ; Galli, Francesca ; Galli, Fabio ; Rulli, Eliana ; Lonardi, Sara ; Ronzoni, Monica ; Massidda, Bruno ; Zagonel, Vittorina ; Pella, Nicoletta ; Mucciarini, Claudia ; Labianca, Roberto ; Ionta, Maria Teresa ; Bagaloni, Irene ; Veltri, Enzo ; Sozzi, Pietro ; Barni, Sandro ; Ricci, Vincenzo ; Foltran, Luisa ; Nicolini, Mario ; Biondi, Edoardo ; Bramati, Annalisa ; Turci, Daniele ; Lazzarelli, Silvia ; Verusio, Claudio ; Bergamo, Francesca ; Sobrero, Alberto ; Frontini, Luciano ; Magnani, Mauro
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-01, Vol.10 (1), p.1918-1918, Article 1918
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VEGF gene polymorphisms and susceptibility to colorectal cancer disease in Italian population
Author / Creator:Maltese, Paolo ; Canestrari, Emanuele ; Ruzzo, Annamaria ; Graziano, Francesco ; Falcone, Alfredo ; Loupakis, Fotios ; Tonini, Giuseppe ; Santini, Daniele ; Magnani, Mauro
Publisher:Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Journal title:International journal of colorectal disease, 2009-02, Vol.24 (2), p.165-170
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A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population
Author / Creator:Nasri, Soroush ; More, Helen ; Graziano, Francesco ; Ruzzo, Annamaria ; Wilson, Emily ; Dunbier, Anita ; McKinney, Cushla ; Merriman, Tony ; Guilford, Parry ; Magnani, Mauro ; Humar, Bostjan
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2008-05, Vol.8 (1), p.138-138, Article 138
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Clinical impact of TP53 functional mutations in patients with metastatic colorectal cancer treated with bevacizumab and chemotherapy
Author / Creator:Ruzzo, Annamaria ; Graziano, Francesco ; Palladino, Silvia ; Fischer, Nicholas W ; Catalano, Vincenzo ; Giordani, Paolo ; Malkin, David ; Tamburrano, Tiziana ; Patriti, Alberto ; Petrelli, Filippo ; Sarti, Donatella ; Chiari, Rita
Publisher:England
Journal title:The oncologist (Dayton, Ohio), 2024-10
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Genetic modulation of the interleukin 6 (IL-6) system in patients with advanced gastric cancer: a background for an alternative target therapy
Author / Creator:Ruzzo, Annamaria ; Catalano, Vincenzo ; Canestrari, Emanuele ; Giacomini, Elisa ; Santini, Daniele ; Tonini, Giuseppe ; Vincenzi, Bruno ; Fiorentini, Giammaria ; Magnani, Mauro ; Graziano, Francesco
Publisher:England: BioMed Central
Journal title:BMC cancer, 2014-05, Vol.14 (1), p.357-357, Article 357
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Genetic markers for toxicity of adjuvant oxaliplatin and fluoropyrimidines in the phase III TOSCA trial in high-risk colon cancer patients
Author / Creator:Ruzzo, Annamaria ; Graziano, Francesco ; Galli, Fabio ; Giacomini, Elisa ; Floriani, Irene ; Galli, Francesca ; Rulli, Eliana ; Lonardi, Sara ; Ronzoni, Monica ; Massidda, Bruno ; Zagonel, Vittorina ; Pella, Nicoletta ; Mucciarini, Claudia ; Labianca, Roberto ; Ionta, Maria Teresa ; Veltri, Enzo ; Sozzi, Pietro ; Barni, Sandro ; Ricci, Vincenzo ; Foltran, Luisa ; Nicolini, Mario ; Biondi, Edoardo ; Bramati, Annalisa ; Turci, Daniele ; Lazzarelli, Silvia ; Verusio, Claudio ; Bergamo, Francesca ; Sobrero, Alberto ; Frontini, Luciano ; Magnani, Mauro
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2014-11, Vol.4 (1), p.6828, Article 6828
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TP53 Mutation Analysis in Gastric Cancer and Clinical Outcomes of Patients with Metastatic Disease Treated with Ramucirumab/Paclitaxel or Standard Chemotherapy
Author / Creator:Graziano, Francesco ; Fischer, Nicholas W. ; Bagaloni, Irene ; Di Bartolomeo, Maria ; Lonardi, Sara ; Vincenzi, Bruno ; Perrone, Giuseppe ; Fornaro, Lorenzo ; Ongaro, Elena ; Aprile, Giuseppe ; Bisonni, Renato ; Prisciandaro, Michele ; Malkin, David ; Gariépy, Jean ; Fassan, Matteo ; Loupakis, Fotios ; Sarti, Donatella ; Del Prete, Michela ; Catalano, Vincenzo ; Alessandroni, Paolo ; Magnani, Mauro ; Ruzzo, Annamaria
Publisher:Basel: MDPI AG
Journal title:Cancers, 2020-07, Vol.12 (8), p.2049
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Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition
Author / Creator:Wong, Gabrielle S. ; Zhou, Jin ; Bin Liu, Jie ; Wu, Zhong ; Xu, Xinsen ; Li, Tianxia ; Xu, David ; Schumacher, Steven E. ; Puschhof, Jens ; McFarland, James ; Zou, Charles ; Dulak, Austin ; Henderson, Les ; Xu, Peng ; O’Day, Emily ; Rendak, Rachel ; Liao, Wei-li ; Cecchi, Fabiola ; Hembrough, Todd ; Schwartz, Sarit ; Szeto, Christopher ; Rustgi, Anil K. ; Wong, Kwok-Kin ; Diehl, J. Alan ; Jensen, Karin ; Graziano, Francesco ; Ruzzo, Annamaria ; Fereshetian, Shaunt ; Mertins, Philipp ; Carr, Steven A. ; Beroukhim, Rameen ; Nakamura, Kenichi ; Oki, Eiji ; Watanabe, Masayuki ; Baba, Hideo ; Imamura, Yu ; Catenacci, Daniel ; Bass, Adam J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2018-10, Vol.24 (10), p.1627-1627
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ArticlesPeer ReviewedFull Text
Targeting wild-type KRAS amplified gastroesophageal cancer through combined MEK and SHP2
Author / Creator:Wong, Gabrielle S. ; Zhou, Jin ; Liu, Jie Bin ; Wu, Zhong ; Xu, Xinsen ; Li, Tianxia ; Xu, David ; Schumacher, Steven E. ; Puschhof, Jens ; McFarland, James ; Zou, Charles ; Dulak, Austin ; Henderson, Les ; Xu, Peng ; O’Day, Emily ; Rendak, Rachel ; Liao, Wei-li ; Cecchi, Fabiola ; Hembrough, Todd ; Schwartz, Sarit ; Szeto, Christopher ; Rustgi, Anil K. ; Wong, Kwok-Kin ; Diehl, J. Alan ; Jensen, Karin ; Graziano, Francesco ; Ruzzo, Annamaria ; Fereshetian, Shaunt ; Mertins, Philipp ; Carr, Steven A. ; Beroukhim, Rameen ; Nakamura, Kenichi ; Oki, Eiji ; Watanabe, Masayuki ; Baba, Hideo ; Imamura, Yu ; Catenacci, Daniel ; Bass, Adam J.
Journal title:Nature medicine, 2018-05, Vol.24 (7), p.968-977
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ArticlesPeer ReviewedFull Text
Host genetic variants in the IGF binding protein-3 impact on survival of patients with advanced gastric cancer treated with palliative chemotherapy
Author / Creator:Graziano, Francesco ; Ruzzo, Annamaria ; Canestrari, Emanuele ; Catalano, Vincenzo ; Santini, Daniele ; Galluccio, Nadia ; Loupakis, Fotios ; Alessandroni, Paolo ; Spada, Daniele ; Ficarelli, Rita ; Bisonni, Renato ; D Emidio, Silvia ; Vincenzi, Bruno ; Angeletti, Silvia ; Salvatore, Lisa ; Cremolini, Chiara ; Tonini, Giuseppe ; Falcone, Alfredo ; Magnani, Mauro
Publisher:England: Future Medicine Ltd
Journal title:Pharmacogenomics, 2010-09, Vol.11 (9), p.1247-1256
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Predictive and Prognostic Role of E-Cadherin Protein Expression in Patients with Advanced Gastric Carcinomas Treated with Palliative Chemotherapy
Author / Creator:Graziano, Francesco ; Mandolesi, Alessandra ; Ruzzo, Annamaria ; Bearzi, Italo ; Testa, Enrica ; Arduini, Federica ; Silva, Rosarita ; Muretto, Pietro ; Mari, Davide ; Berardi, Rossana ; Scartozzi, Mario ; Lai, Vittorio ; Cascinu, Stefano ; Magnani, Mauro
Publisher:Basel, Switzerland: Springer Nature B.V
Journal title:Tumor biology, 2004-05, Vol.25 (3), p.106-110
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ReportsFull Text
XRCC1 399GG genotype predicts significantly longer overall survival in resistant lymphoma patients treated with Benda-EAM and ASCT
Author / Creator:Visani, Giuseppe ; Loscocco, Federica ; Bagaloni, Irene ; Ruzzo, Annamaria ; Fuligni, Fabio ; Graziano, Francesco ; Magnani, Mauro
Publisher:Nature Publishing Group
Journal title:Bone Marrow Transplantation, 2020, Vol.55 (4), p.818
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Molecular basis of 2',3'-dideoxycytidine-induced drug resistance in human cells
Author / Creator:Innoceta, Annamaria ; Galluzzi, Luca ; Ruzzo, Annamaria ; Andreoni, Francesca ; Chiarantini, Laura ; Magnani, Mauro
Publisher:Netherlands: Springer Nature B.V
Journal title:Molecular and cellular biochemistry, 2002-02, Vol.231 (1-2), p.173-177
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Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

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KRAS4A and KRAS4B in liquid biopsy of metastatic lung adenocarcinoma patients treated with Pembrolizumab or chemotherapy plus Pembrolizumab

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XRCC1 399GG genotype predicts significantly longer overall survival in resistant lymphoma patients treated with Benda-EAM and ASCT

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Prospective validation of candidate SNPs of VEGF/VEGFR pathway in metastatic colorectal cancer patients treated with first-line FOLFIRI plus bevacizumab

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Sex-Related Differences in Impact on Safety of Pharmacogenetic Profile for Colon Cancer Patients Treated with FOLFOX-4 or XELOX Adjuvant Chemotherapy

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Retrospective exploratory analysis of VEGF polymorphisms in the prediction of benefit from first-line FOLFIRI plus bevacizumab in metastatic colorectal cancer

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Gender effects of single nucleotide polymorphisms and miRNAs targeting clock-genes in metastatic colorectal cancer patients (mCRC)

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Author Correction: Sex-Related Differences in Impact on Safety of Pharmacogenetic Profile for Colon Cancer Patients Treated with FOLFOX-4 or XELOX Adjuvant Chemotherapy

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VEGF gene polymorphisms and susceptibility to colorectal cancer disease in Italian population

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A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population

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Clinical impact of TP53 functional mutations in patients with metastatic colorectal cancer treated with bevacizumab and chemotherapy

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Genetic modulation of the interleukin 6 (IL-6) system in patients with advanced gastric cancer: a background for an alternative target therapy

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Genetic markers for toxicity of adjuvant oxaliplatin and fluoropyrimidines in the phase III TOSCA trial in high-risk colon cancer patients

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TP53 Mutation Analysis in Gastric Cancer and Clinical Outcomes of Patients with Metastatic Disease Treated with Ramucirumab/Paclitaxel or Standard Chemotherapy

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Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

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Targeting wild-type KRAS amplified gastroesophageal cancer through combined MEK and SHP2

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Host genetic variants in the IGF binding protein-3 impact on survival of patients with advanced gastric cancer treated with palliative chemotherapy

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Predictive and Prognostic Role of E-Cadherin Protein Expression in Patients with Advanced Gastric Carcinomas Treated with Palliative Chemotherapy

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XRCC1 399GG genotype predicts significantly longer overall survival in resistant lymphoma patients treated with Benda-EAM and ASCT

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Molecular basis of 2',3'-dideoxycytidine-induced drug resistance in human cells

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