Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition
Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition
About this item
Full title
Author / Creator
Wong, Gabrielle S. , Zhou, Jin , Liu, Jie Bin , Wu, Zhong , Xu, Xinsen , Li, Tianxia , Xu, David , Schumacher, Steven E. , Puschhof, Jens , McFarland, James , Zou, Charles , Dulak, Austin , Henderson, Les , Xu, Peng , O’Day, Emily , Rendak, Rachel , Liao, Wei-li , Cecchi, Fabiola , Hembrough, Todd , Schwartz, Sarit , Szeto, Christopher , Rustgi, Anil K. , Wong, Kwok-Kin , Diehl, J. Alan , Jensen, Karin , Graziano, Francesco , Ruzzo, Annamaria , Fereshetian, Shaunt , Mertins, Philipp , Carr, Steven A. , Beroukhim, Rameen , Nakamura, Kenichi , Oki, Eiji , Watanabe, Masayuki , Baba, Hideo , Imamura, Yu , Catenacci, Daniel and Bass, Adam J.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The role of KRAS, when activated through canonical mutations, has been well established in cancer
1
. Here we explore a secondary means of
KRAS
activation in cancer: focal high-level amplification of the
KRAS
gene in the absence of coding mutations. These amplifications occur most commonly in esophageal, gastric and ovarian adenoc...
Alternative Titles
Full title
Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition
Authors, Artists and Contributors
Author / Creator
Zhou, Jin
Liu, Jie Bin
Wu, Zhong
Xu, Xinsen
Li, Tianxia
Xu, David
Schumacher, Steven E.
Puschhof, Jens
McFarland, James
Zou, Charles
Dulak, Austin
Henderson, Les
Xu, Peng
O’Day, Emily
Rendak, Rachel
Liao, Wei-li
Cecchi, Fabiola
Hembrough, Todd
Schwartz, Sarit
Szeto, Christopher
Rustgi, Anil K.
Wong, Kwok-Kin
Diehl, J. Alan
Jensen, Karin
Graziano, Francesco
Ruzzo, Annamaria
Fereshetian, Shaunt
Mertins, Philipp
Carr, Steven A.
Beroukhim, Rameen
Nakamura, Kenichi
Oki, Eiji
Watanabe, Masayuki
Baba, Hideo
Imamura, Yu
Catenacci, Daniel
Bass, Adam J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_2067107951
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2067107951
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-018-0022-x
