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ArticlesPeer ReviewedFull Text
ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia
Author / Creator:Gaudet, Daniel ; Gipe, Daniel A ; Pordy, Robert ; Ahmad, Zahid ; Cuchel, Marina ; Shah, Prediman K ; Chyu, Kuang-Yuh ; Sasiela, William J ; Chan, Kuo-Chen ; Brisson, Diane ; Khoury, Etienne ; Banerjee, Poulabi ; Gusarova, Viktoria ; Gromada, Jesper ; Stahl, Neil ; Yancopoulos, George D ; Hovingh, G. Kees
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2017-07, Vol.377 (3), p.296-297
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ArticlesPeer ReviewedFull Text
Effect of Alirocumab on Lipoprotein(a) Over ≥1.5 Years (From the Phase 3 ODYSSEY Program)
Author / Creator:Gaudet, Daniel, MD, PhD ; Watts, Gerald F., DSc, MD, PhD, FRCP, FRACP ; Robinson, Jennifer G., MD ; Minini, Pascal, PhD ; Sasiela, William J., PhD ; Edelberg, Jay, MD, PhD ; Louie, Michael J., MD ; Raal, Frederick J., PhD
Publisher:United States: Elsevier Inc
Journal title:The American journal of cardiology, 2017-01, Vol.119 (1), p.40-46
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ArticlesPeer ReviewedFull Text
Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study
Author / Creator:Cuchel, Marina, Dr ; Meagher, Emma A, MD ; du Toit Theron, Hendrik, Prof ; Blom, Dirk J, PhD ; Marais, A David, Prof ; Hegele, Robert A, Prof ; Averna, Maurizio R, Prof ; Sirtori, Cesare R, Prof ; Shah, Prediman K, Prof ; Gaudet, Daniel, MD ; Stefanutti, Claudia, MD ; Vigna, Giovanni B, MD ; Du Plessis, Anna ME, MMed ; Propert, Kathleen J, Prof ; Sasiela, William J, PhD ; Bloedon, LeAnne T, MS ; Rader, Daniel J, Prof
Publisher:Kidlington: Elsevier Ltd
Journal title:The Lancet (British edition), 2013-01, Vol.381 (9860), p.40-46
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Newsletter articlesFull Text
Bessac Laurence, Hanotin Corinne, Pordy Robert C, Sasiela William J, Schwartz Gregory G and Steg Philippe Gabriel Submit Patent Application for Methods for Reducing Cardiovascular Risk
Publisher:New Delhi: Pedia Content Solutions Pvt. Ltd
Journal title:Global IP News. Medical Patent News, 2015
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ArticlesPeer ReviewedFull Text
Pharmacokinetics of bempedoic acid in patients with renal impairment
Author / Creator:Amore, Benny M. ; Sasiela, William J. ; Ries, Daniel K. ; Tresh, Perry ; Emery, Maurice G.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2022-03, Vol.15 (3), p.789-798
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ArticlesPeer ReviewedFull Text
Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease
Author / Creator:Nissen, Steven E ; Tuzcu, E. Murat ; Schoenhagen, Paul ; Crowe, Tim ; Sasiela, William J ; Tsai, John ; Orazem, John ; Magorien, Raymond D ; O'Shaughnessy, Charles ; Ganz, Peter
Publisher:Boston, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2005-01, Vol.352 (1), p.29-38
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ArticlesPeer ReviewedFull Text
Prevalence of Tendon Rupture and Tendinopathies Among Patients with Atherosclerotic Cardiovascular Disease Derived From United States Administrative Claims Data
Author / Creator:Gillard, Kristin K. ; Bloedon, LeAnne ; Grady-Benson, John C. ; Edwards, Alison ; Fahy, Sean ; Sasiela, William J. ; Louie, Michael J. ; Thompson, Paul D.
Publisher:Cheshire: Springer Healthcare
Journal title:Cardiology and therapy, 2024-09, Vol.13 (3), p.575-591
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ArticlesPeer ReviewedFull Text
Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers
Author / Creator:Amore, Benny M. ; Cramer, Clay T. ; MacDougall, Diane E. ; Sasiela, William J. ; Emery, Maurice G.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2021-11, Vol.14 (6), p.2487-2496
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ArticlesPeer ReviewedFull Text
Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients
Author / Creator:Nissen, Steven E. ; Lincoff, A. Michael ; Brennan, Danielle ; Ray, Kausik K. ; Mason, Denise ; Kastelein, John J.P. ; Thompson, Paul D. ; Libby, Peter ; Cho, Leslie ; Plutzky, Jorge ; Bays, Harold E. ; Moriarty, Patrick M. ; Menon, Venu ; Grobbee, Diederick E. ; Louie, Michael J. ; Chen, Chien-Feng ; Li, Na ; Bloedon, LeAnne ; Robinson, Paula ; Horner, Maggie ; Sasiela, William J. ; McCluskey, Jackie ; Davey, Deborah ; Fajardo-Campos, Pedro ; Petrovic, Predrag ; Fedacko, Jan ; Zmuda, Witold ; Lukyanov, Yury ; Nicholls, Stephen J.
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2023-04, Vol.388 (15), p.1353-1364
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ArticlesPeer ReviewedFull Text
A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics
Author / Creator:Ming, Jeffrey E ; Abrams, Ruth E ; Bartlett, Derek W ; Tao, Mengdi ; Nguyen, Tu ; Surks, Howard ; Kudrycki, Katherine ; Kadambi, Ananth ; Friedrich, Christina M ; Djebli, Nassim ; Goebel, Britta ; Koszycki, Alex ; Varshnaya, Meera ; Elassal, Joseph ; Banerjee, Poulabi ; Sasiela, William J ; Reed, Michael J ; Barrett, Jeffrey S ; Azer, Karim
Publisher:London, England: Libertas Academica
Journal title:Gene Regulation and Systems Biology, 2017-06, Vol.2017 (11), p.1-15-008
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ArticlesPeer ReviewedFull Text
Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: Rationale and design of the ODYSSEY Outcomes trial
Author / Creator:Schwartz, Gregory G., MD, PhD ; Bessac, Laurence, MD ; Berdan, Lisa G., PA, MHS ; Bhatt, Deepak L., MD, MPH ; Bittner, Vera, MD ; Diaz, Rafael, MD ; Goodman, Shaun G., MD, MSc ; Hanotin, Corinne, MD ; Harrington, Robert A., MD ; Jukema, J. Wouter, MD, PhD ; Mahaffey, Kenneth W., MD ; Moryusef, Angèle, MD ; Pordy, Robert, MD ; Roe, Matthew T., MD, MPH ; Rorick, Tyrus, RN ; Sasiela, William J., PhD ; Shirodaria, Cheerag, MBBS ; Szarek, Michael, PhD ; Tamby, Jean-François, MD ; Tricoci, Pierluigi, MD ; White, Harvey, MBBS, DSc ; Zeiher, Andreas, MD ; Steg, Philippe Gabriel, MD
Publisher:United States: Elsevier Inc
Journal title:The American heart journal, 2014-11, Vol.168 (5), p.682-689.e1
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ArticlesPeer ReviewedFull Text
Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia
Author / Creator:Jadhav, Satyawan B ; Amore, Benny M ; Bockbrader, Howard ; Crass, Ryan L ; Chapel, Sunny ; Sasiela, William J ; Emery, Maurice G
Publisher:New York: Springer Nature B.V
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2023-10, Vol.50 (5), p.351-364
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ArticlesPeer ReviewedFull Text
Simulation of the Impact of Statin Intolerance on the Need for Ezetimibe and/or Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor for Meeting Low-Density Lipoprotein Cholesterol Goals in a Popul...
Author / Creator:Cannon, Christopher P. ; Sanchez, Robert J. ; Klimchak, Alexa C. ; Khan, Irfan ; Sasiela, William J. ; Reynolds, Matthew R. ; Rosenson, Robert S.
Publisher:United States: Elsevier Inc
Journal title:The American journal of cardiology, 2019-04, Vol.123 (8), p.1202-1207
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ArticlesPeer ReviewedFull Text
Impact of the COVID‐19 Pandemic on Conduct and Results of CLEAR Outcomes Trial
Author / Creator:Singh, Abhayjit ; Laffin, Luke J. ; Sarraju, Ashish ; Michael Lincoff, A. ; Nicholls, Stephen J. ; Bloedon, LeAnne ; Sasiela, William J. ; Li, Na ; Robinson, Paula ; Kelly, Stephanie ; Mason, Denise ; Nissen, Steven E.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical cardiology (Mahwah, N.J.), 2024-08, Vol.47 (8), p.e24328-n/a
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ArticlesPeer ReviewedFull Text
Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia
Author / Creator:Samaha, Frederick F ; McKenney, James ; Bloedon, LeAnne T ; Sasiela, William J ; Rader, Daniel J
Publisher:London: Nature Publishing Group UK
Journal title:Nature clinical practice cardiovascular medicine, 2008-08, Vol.5 (8), p.497-505
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ArticlesPeer ReviewedFull Text
Simulation of impact on cardiovascular events due to lipid-lowering therapy intensification in a population with atherosclerotic cardiovascular disease
Author / Creator:Cannon, Christopher P. ; Khan, Irfan ; Klimchak, Alexa C. ; Sanchez, Robert J. ; Sasiela, William J. ; Massaro, Joseph M. ; D'Agostino, Ralph B. ; Reynolds, Matthew R.
Publisher:United States: Elsevier Inc
Journal title:The American heart journal, 2019-10, Vol.216, p.30-41
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ArticlesFull Text
Potential Cardiovascular Events Avoided with Bempedoic Acid Plus Ezetimibe Fixed-Dose Combination Compared with Ezetimibe Alone in Patients with Atherosclerotic Cardiovascular Disease Taking Maximally...
Author / Creator:McQueen, R. Brett ; Baum, Seth J. ; Louie, Michael J. ; Sasiela, William J. ; Bilitou, Aikaterini ; Shah, Hemal ; Nash, Beth ; Gillard, Kristin K. ; Ray, Kausik K.
Publisher:Cham: Springer International Publishing
Journal title:American journal of cardiovascular drugs : drugs, devices, and other interventions, 2023-01, Vol.23 (1), p.67-76
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ArticlesPeer ReviewedFull Text
Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose–response model
Author / Creator:Jadhav, Satyawan B ; Crass, Ryan L ; Chapel, Sunny ; Kerschnitzki, Michael ; Sasiela, William J ; Emery, Maurice G ; Amore, Benny M ; Barrett, P Hugh R ; Watts, Gerald F ; Catapano, Alberico L
Publisher:England: Oxford University Press
Journal title:European heart journal. Cardiovascular pharmacotherapy, 2022-09, Vol.8 (6), p.578-586
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ArticlesPeer ReviewedFull Text
New strategies for the development of lipid-lowering therapies to reduce cardiovascular risk
Author / Creator:Graham, Ian ; Shear, Chuck ; De Graeff, Pieter ; Boulton, Caroline ; Catapano, Alberico L ; Stough, Wendy Gattis ; Carlsson, Stefan C ; De Backer, Guy ; Emmerich, Joseph ; Greenfeder, Scott ; Kim, Albert M ; Lautsch, Dominik ; Nguyen, Tu ; Nissen, Steven E ; Prasad, Krishna ; Ray, Kausik K ; Robinson, Jennifer G ; Sasiela, William J ; Bruins Slot, Karsten ; Stroes, Erik ; Thuren, Tom ; Van der Schueren, Bart ; Velkovski-Rouyer, Maja ; Wasserman, Scott M ; Wiklund, Olov ; Zouridakis, Emmanouil
Publisher:England: Oxford University Press (OUP)
Journal title:European Heart Journal - Cardiovascular Pharmacotherapy, 2018-04, Vol.4 (2), p.119-127
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ArticlesPeer ReviewedFull Text
Relation of Characteristics of Metabolic Syndrome to Short-Term Prognosis and Effects of Intensive Statin Therapy After Acute Coronary Syndrome: An analysis of the Myocardial Ischemia Reduction with A...
Author / Creator:Schwartz, Gregory G ; Olsson, Anders G ; Szarek, Michael ; Sasiela, William J
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes care, 2005-10, Vol.28 (10), p.2508-2513
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Showing 1 to 20 of 24 results

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ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia

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Effect of Alirocumab on Lipoprotein(a) Over ≥1.5 Years (From the Phase 3 ODYSSEY Program)

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Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study

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Bessac Laurence, Hanotin Corinne, Pordy Robert C, Sasiela William J, Schwartz Gregory G and Steg Philippe Gabriel Submit Patent Application for Methods for Reducing Cardiovascular Risk

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Pharmacokinetics of bempedoic acid in patients with renal impairment

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Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease

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Prevalence of Tendon Rupture and Tendinopathies Among Patients with Atherosclerotic Cardiovascular Disease Derived From United States Administrative Claims Data

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Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers

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Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients

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A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics

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Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: Rationale and design of the ODYSSEY Outcomes trial

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Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia

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Simulation of the Impact of Statin Intolerance on the Need for Ezetimibe and/or Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor for Meeting Low-Density Lipoprotein Cholesterol Goals in a Popul...

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Impact of the COVID‐19 Pandemic on Conduct and Results of CLEAR Outcomes Trial

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Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia

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Simulation of impact on cardiovascular events due to lipid-lowering therapy intensification in a population with atherosclerotic cardiovascular disease

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Potential Cardiovascular Events Avoided with Bempedoic Acid Plus Ezetimibe Fixed-Dose Combination Compared with Ezetimibe Alone in Patients with Atherosclerotic Cardiovascular Disease Taking Maximally...

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Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose–response model

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New strategies for the development of lipid-lowering therapies to reduce cardiovascular risk

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Relation of Characteristics of Metabolic Syndrome to Short-Term Prognosis and Effects of Intensive Statin Therapy After Acute Coronary Syndrome: An analysis of the Myocardial Ischemia Reduction with A...

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