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ArticlesPeer ReviewedFull Text
Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis
Author / Creator:Rombouts, Yoann ; Ewing, Ewoud ; van de Stadt, Lotte A ; Selman, Maurice H J ; Trouw, Leendert A ; Deelder, André M ; Huizinga, Tom W J ; Wuhrer, Manfred ; van Schaardenburg, Dirkjan ; Toes, René E M ; Scherer, Hans U
Publisher:England: Elsevier Limited
Journal title:Annals of the rheumatic diseases, 2015-01, Vol.74 (1), p.234-241
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Defining conditions where long-term glucocorticoid treatment has an acceptably low level of harm to facilitate implementation of existing recommendations: viewpoints from an EULAR task force
Author / Creator:Strehl, Cindy ; Bijlsma, Johannes W J ; de Wit, Maarten ; Boers, Maarten ; Caeyers, Nele ; Cutolo, Maurizio ; Dasgupta, Bhaskar ; Dixon, William G ; Geenen, Rinie ; Huizinga, Tom W J ; Kent, Alison ; de Thurah, Annette Ladefoged ; Listing, Joachim ; Mariette, Xavier ; Ray, David W ; Scherer, Hans U ; Seror, Raphaèle ; Spies, Cornelia M ; Tarp, Simon ; Wiek, Dieter ; Winthrop, Kevin L ; Buttgereit, Frank
Publisher:England: Elsevier Limited
Journal title:Annals of the rheumatic diseases, 2016-06, Vol.75 (6), p.952-957
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ArticlesPeer ReviewedFull Text
Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis
Author / Creator:Rombouts, Yoann ; Willemze, Annemiek ; van Beers, Joyce J B C ; Shi, Jing ; Kerkman, Priscilla F ; van Toorn, Linda ; Janssen, George M C ; Zaldumbide, Arnaud ; Hoeben, Rob C ; Pruijn, Ger J M ; Deelder, André M ; Wolbink, Gertjan ; Rispens, Theo ; van Veelen, Peter A ; Huizinga, Tom W J ; Wuhrer, Manfred ; Trouw, Leendert A ; Scherer, Hans U ; Toes, René E M
Publisher:England: Elsevier Limited
Journal title:Annals of the rheumatic diseases, 2016-03, Vol.75 (3), p.578-585
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ArticlesPeer ReviewedFull Text
Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopaus...
Author / Creator:Engdahl, Cecilia ; Bondt, Albert ; Harre, Ulrike ; Raufer, Jasmin ; Pfeifle, René ; Camponeschi, Alessandro ; Wuhrer, Manfred ; Seeling, Michaela ; Mårtensson, Inga-Lill ; Nimmerjahn, Falk ; Krönke, Gerhard ; Scherer, Hans U ; Forsblad-d'Elia, Helena ; Schett, Georg
Publisher:England: BioMed Central Ltd
Journal title:Arthritis research & therapy, 2018-05, Vol.20 (1), p.84-84, Article 84
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ArticlesPeer ReviewedFull Text
Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis
Author / Creator:Kroos, Sanne ; Kampstra, Arieke S. B. ; Toes, René E. M. ; Slot, Linda M. ; Scherer, Hans U.
Publisher:London: BioMed Central Ltd
Journal title:Arthritis research & therapy, 2022-10, Vol.24 (1), p.1-230, Article 230
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ArticlesPeer ReviewedFull Text
Anti-carbamylated protein antibodies in systemic sclerosis
Author / Creator:Liem, Sophie I E ; Hoekstra, E M ; Levarht, E W Nivine ; Dorjee, Annemarie L ; Scherer, Hans U ; Toes, René E M ; Huizinga, Tom W J ; de Vries-Bouwstra, Jeska K ; Fehres, Cynthia M
Publisher:England: BioMed Central Ltd
Journal title:Arthritis research & therapy, 2023-07, Vol.25 (1), p.123-123, Article 123
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ArticlesPeer ReviewedFull Text
Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load
Author / Creator:Reijm, Sanne ; Kissel, Theresa ; Stoeken-Rijsbergen, Gerrie ; Slot, Linda M. ; Wortel, Corrie M. ; van Dooren, Hugo J. ; Levarht, Nivine E. W. ; Kampstra, Arieke S. B. ; Derksen, Veerle F. A. M. ; Heer, Pleuni Ooijevaar-de ; Bang, Holger ; Drijfhout, Jan W. ; Trouw, Leendert A. ; Huizinga, Tom W. J. ; Rispens, Theo ; Scherer, Hans U. ; Toes, René E. M.
Publisher:London: BioMed Central Ltd
Journal title:Arthritis research & therapy, 2021-09, Vol.23 (1), p.1-230, Article 230
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ArticlesPeer ReviewedFull Text
Synovial fluid mononuclear cells provide an environment for long-term survival of antibody-secreting cells and promote the spontaneous production of anti-citrullinated protein antibodies
Author / Creator:Kerkman, Priscilla F ; Kempers, Ayla C ; van der Voort, Ellen I H ; van Oosterhout, Maikel ; Huizinga, Tom W J ; Toes, René E M ; Scherer, Hans U
Publisher:England: Elsevier Limited
Journal title:Annals of the rheumatic diseases, 2016-12, Vol.75 (12), p.2201-2207
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ArticlesPeer ReviewedFull Text
Light chain skewing in autoantibodies and B-cell receptors of the citrullinated antigen-binding B-cell response in rheumatoid arthritis
Author / Creator:Slot, Linda M ; Vergroesen, Rochelle D ; Kerkman, Priscilla F ; Staudinger, Ellen ; Reijm, Sanne ; van Dooren, Hugo J ; van der Voort, Ellen I H ; Huizinga, Tom W J ; Toes, René E M ; Scherer, Hans U
Publisher:United States: Public Library of Science
Journal title:PloS one, 2021-03, Vol.16 (3), p.e0247847-e0247847
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ArticlesPeer ReviewedFull Text
Anti-topoisomerase, but not anti-centromere B cell responses in systemic sclerosis display active, Ig-secreting cells associated with lung fibrosis
Author / Creator:Wortel, Corrie M ; Liem, Sophie IE ; van Leeuwen, Nina M ; Boonstra, Maaike ; Fehres, Cynthia M ; Stöger, Lauran ; Huizinga, Tom WJ ; Toes, René EM ; De Vries-Bouwstra, Jeska ; Scherer, Hans U
Publisher:England: EULAR
Journal title:Rheumatic & musculoskeletal diseases open, 2023-07, Vol.9 (3), p.e003148
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ArticlesPeer ReviewedFull Text
Rituximab in early systemic sclerosis
Author / Creator:Boonstra, Maaike ; Meijs, Jessica ; Dorjée, Annemarie L ; Marsan, Nina Ajmone ; Schouffoer, Anne ; Ninaber, Maarten K ; Quint, Koen D ; Bonte-Mineur, Femke ; Huizinga, Tom W J ; Scherer, Hans U ; de Vries-Bouwstra, Jeska K
Publisher:England: BMJ Publishing Group LTD
Journal title:Rheumatic & musculoskeletal diseases open, 2017-07, Vol.3 (2), p.e000384-e000384
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ArticlesPeer ReviewedFull Text
B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of N-glycosylation sites during somatic hypermutati...
Author / Creator:Vergroesen, Rochelle D ; Slot, Linda M ; Hafkenscheid, Lise ; Koning, Marvyn T ; van der Voort, Ellen I H ; Grooff, Christine A ; Zervakis, George ; Veelken, Hendrik ; Huizinga, Tom W J ; Rispens, Theo ; Scherer, Hans U ; Toes, René E M
Publisher:England: Elsevier Limited
Journal title:Annals of the rheumatic diseases, 2018-06, Vol.77 (6), p.956-958
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ArticlesPeer ReviewedFull Text
Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis
Author / Creator:Kerkman, Priscilla F ; Fabre, Emeline ; van der Voort, Ellen I H ; Zaldumbide, Arnaud ; Rombouts, Yoann ; Rispens, Theo ; Wolbink, Gertjan ; Hoeben, Rob C ; Spits, Hergen ; Baeten, Dominique L P ; Huizinga, Tom W J ; Toes, René E M ; Scherer, Hans U
Publisher:England: Elsevier Limited
Journal title:Annals of the rheumatic diseases, 2016-06, Vol.75 (6), p.1170-1176
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ArticlesPeer ReviewedFull Text
Response to: ‘Acquiring new N-glycosylation sites in variable regions of immunoglobulin genes by somatic hypermutation is a common feature of autoimmune diseases’ by Visser et al
Author / Creator:Vergroesen, Rochelle D ; Slot, Linda M ; Hafkenscheid, Lise ; Koning, Marvyn T ; Scherer, Hans U ; Toes, René E M
Publisher:England: Elsevier B.V
Journal title:Annals of the rheumatic diseases, 2018-10, Vol.77 (10), p.e70-e70
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ArticlesPeer ReviewedFull Text
Circulating plasmablasts/plasmacells as a source of anticitrullinated protein antibodies in patients with rheumatoid arthritis
Author / Creator:Kerkman, Priscilla F ; Rombouts, Yoann ; van der Voort, Ellen I H ; Trouw, Leendert A ; Huizinga, Tom W J ; Toes, René EM ; Scherer, Hans U
Publisher:England: BMJ Publishing Group Ltd and European League Against Rheumatism
Journal title:Annals of the rheumatic diseases, 2013-07, Vol.72 (7), p.1259-1263
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ArticlesPeer ReviewedFull Text
Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities
Author / Creator:Ioan-Facsinay, Andreea ; el-Bannoudi, Hanane ; Scherer, Hans U ; van der Woude, Diane ; Ménard, Henri A ; Lora, Maximilien ; Trouw, Leendert A ; Huizinga, Tom W J ; Toes, Rene E M
Publisher:London: BMJ Publishing Group Ltd and European League Against Rheumatism
Journal title:Annals of the rheumatic diseases, 2011-01, Vol.70 (1), p.188-193
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ArticlesPeer ReviewedFull Text
Benchmarking computational methods for B-cell receptor reconstruction from single-cell RNA-seq data
Author / Creator:Andreani, Tommaso ; Slot, Linda M ; Gabillard, Samuel ; Strübing, Carsten ; Reimertz, Claus ; Yaligara, Veeranagouda ; Bakker, Aleida M ; Olfati-Saber, Reza ; Toes, René E M ; Scherer, Hans U ; Augé, Franck ; Šimaitė, Deimantė
Publisher:Oxford: Oxford University Press
Journal title:NAR genomics and bioinformatics, 2022-09, Vol.4 (3), p.lqac049-lqac049
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ArticlesPeer ReviewedFull Text
Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease
Author / Creator:Pfeifle, René ; Rothe, Tobias ; Ipseiz, Natacha ; Scherer, Hans U ; Culemann, Stephan ; Harre, Ulrike ; Ackermann, Jochen A ; Seefried, Martina ; Kleyer, Arnd ; Uderhardt, Stefan ; Haugg, Benjamin ; Hueber, Axel J ; Daum, Patrick ; Heidkamp, Gordon F ; Ge, Changrong ; Böhm, Sybille ; Lux, Anja ; Schuh, Wolfgang ; Magorivska, Iryna ; Nandakumar, Kutty S ; Lönnblom, Erik ; Becker, Christoph ; Dudziak, Diana ; Wuhrer, Manfred ; Rombouts, Yoann ; Koeleman, Carolien A ; Toes, René ; Winkler, Thomas H ; Holmdahl, Rikard ; Herrmann, Martin ; Blüml, Stephan ; Nimmerjahn, Falk ; Schett, Georg ; Krönke, Gerhard
Publisher:New York: Nature Publishing Group US
Journal title:Nature Immunology, 2017-01, Vol.18 (1), p.104-113
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ArticlesPeer ReviewedFull Text
Mesenchymal stem cells in autoimmune diseases: hype or hope?
Author / Creator:Scherer, Hans U ; van Pel, Melissa ; Toes, René E M
Publisher:England: BioMed Central Ltd
Journal title:Arthritis research & therapy, 2010-01, Vol.12 (3), p.126-126
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ArticlesPeer ReviewedFull Text
Is there a role for mannan-binding lectin in the diagnosis of inflammatory bowel disease
Author / Creator:Hoffmann, Christina ; Hoffmann, Peter ; Lun, Andreas ; Büning, Carsten ; Hiepe, Falk ; Scherer, Hans U ; Steinhagen-Thiessen, Elisabeth ; Weimann, Andreas
Publisher:Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Journal title:Immunogenetics (New York), 2010-04, Vol.62 (4), p.231-235
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Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis

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Defining conditions where long-term glucocorticoid treatment has an acceptably low level of harm to facilitate implementation of existing recommendations: viewpoints from an EULAR task force

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Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis

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Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopaus...

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Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis

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Anti-carbamylated protein antibodies in systemic sclerosis

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Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load

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Synovial fluid mononuclear cells provide an environment for long-term survival of antibody-secreting cells and promote the spontaneous production of anti-citrullinated protein antibodies

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Light chain skewing in autoantibodies and B-cell receptors of the citrullinated antigen-binding B-cell response in rheumatoid arthritis

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Anti-topoisomerase, but not anti-centromere B cell responses in systemic sclerosis display active, Ig-secreting cells associated with lung fibrosis

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Rituximab in early systemic sclerosis

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B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of N-glycosylation sites during somatic hypermutati...

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Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis

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Response to: ‘Acquiring new N-glycosylation sites in variable regions of immunoglobulin genes by somatic hypermutation is a common feature of autoimmune diseases’ by Visser et al

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Circulating plasmablasts/plasmacells as a source of anticitrullinated protein antibodies in patients with rheumatoid arthritis

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Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities

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Benchmarking computational methods for B-cell receptor reconstruction from single-cell RNA-seq data

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Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease

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Mesenchymal stem cells in autoimmune diseases: hype or hope?

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Is there a role for mannan-binding lectin in the diagnosis of inflammatory bowel disease

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