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ArticlesPeer ReviewedFull Text
Structure of the human smoothened receptor bound to an antitumour agent
Author / Creator:Wang, Chong ; Wu, Huixian ; Katritch, Vsevolod ; Han, Gye Won ; Huang, Xi-Ping ; Liu, Wei ; Siu, Fai Yiu ; Roth, Bryan L. ; Cherezov, Vadim ; Stevens, Raymond C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-05, Vol.497 (7449), p.338-343
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Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs
Author / Creator:Wang, Chong ; Wu, Huixian ; Evron, Tama ; Vardy, Eyal ; Han, Gye Won ; Huang, Xi-Ping ; Hufeisen, Sandy J. ; Mangano, Thomas J. ; Urban, Dan J. ; Katritch, Vsevolod ; Cherezov, Vadim ; Caron, Marc G. ; Roth, Bryan L. ; Stevens, Raymond C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-07, Vol.5 (1), p.4355, Article 4355
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Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand
Author / Creator:Zhang, Xianjun ; Zhao, Fei ; Wu, Yiran ; Yang, Jun ; Han, Gye Won ; Zhao, Suwen ; Ishchenko, Andrii ; Ye, Lintao ; Lin, Xi ; Ding, Kang ; Dharmarajan, Venkatasubramanian ; Griffin, Patrick R. ; Gati, Cornelius ; Nelson, Garrett ; Hunter, Mark S. ; Hanson, Michael A. ; Cherezov, Vadim ; Stevens, Raymond C. ; Tan, Wenfu ; Tao, Houchao ; Xu, Fei
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-05, Vol.8 (1), p.15383-15383, Article 15383
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A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury
Author / Creator:Chechneva, O V ; Mayrhofer, F ; Daugherty, D J ; Krishnamurty, R G ; Bannerman, P ; Pleasure, D E ; Deng, W
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2014-10, Vol.5 (10), p.e1481-e1481
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Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination
Author / Creator:Recchia, Antonella Damiana ; Dominicis, Alessandra ; D'Amore, Vincenzo Maria ; Fabiano, Tommaso ; Al Jaf, Aland Ibrahim Ahmed ; Peria, Simone ; Basoli, Francesco ; Rainer, Alberto ; Marinelli, Luciana ; Di Leva, Francesco Saverio ; Ragnini-Wilson, Antonella
Publisher:Switzerland: Frontiers Media S.A
Journal title:Frontiers in molecular neuroscience, 2024-10, Vol.17, p.1473960
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Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
Author / Creator:Deshpande, Ishan ; Liang, Jiahao ; Hedeen, Danielle ; Roberts, Kelsey J. ; Zhang, Yunxiao ; Ha, Betty ; Latorraca, Naomi R. ; Faust, Bryan ; Dror, Ron O. ; Beachy, Philip A. ; Myers, Benjamin R. ; Manglik, Aashish
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-07, Vol.571 (7764), p.284-288
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Structure‐Activity Relationship Studies of Hydantoin‐Cored Ligands for Smoothened Receptor
Author / Creator:Liu, Yang ; Zhou, Fang ; Ding, Kang ; Xue, Dongxiang ; Zhu, Zhihao ; Li, Cuixia ; Li, Fei ; Xu, Yueming ; Xu, Fei ; Le, Zhiping ; Zhao, Suwen ; Tao, Houchao
Publisher:Germany: John Wiley & Sons, Inc
Journal title:ChemistryOpen (Weinheim), 2021-10, Vol.10 (10), p.1028-1032
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Cyclopamine modulates smoothened receptor activity in a binding position dependent manner
Author / Creator:Kim, Kihong ; Bansal, Prateek D. ; Shukla, Diwakar
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2024-09, Vol.7 (1), p.1207-14, Article 1207
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Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
Author / Creator:Qi, Xiaofeng ; Friedberg, Lucas ; De Bose-Boyd, Ryan ; Long, Tao ; Li, Xiaochun
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2020-12, Vol.16 (12), p.1368-1375
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Cholesterol access in cellular membranes controls Hedgehog signaling
Author / Creator:Radhakrishnan, Arun ; Rohatgi, Rajat ; Siebold, Christian
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2020-12, Vol.16 (12), p.1303-1313
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Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats
Author / Creator:Hu, Quan ; Li, Tong ; Wang, Lingxiao ; Xie, Yunkai ; Liu, Song ; Bai, Xuemei ; Zhang, Tiantian ; Bo, Shishi ; Xin, Danqing ; Xue, Hao ; Li, Gang ; Wang, Zhen
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in cellular neuroscience, 2017-01, Vol.10, p.306-306
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Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits
Author / Creator:Arveseth, Corvin D. ; Happ, John T. ; Hedeen, Danielle S. ; Zhu, Ju-Fen ; Capener, Jacob L. ; Klatt Shaw, Dana ; Deshpande, Ishan ; Liang, Jiahao ; Xu, Jiewei ; Stubben, Sara L. ; Nelson, Isaac B. ; Walker, Madison F. ; Kawakami, Kouki ; Inoue, Asuka ; Krogan, Nevan J. ; Grunwald, David J. ; Hüttenhain, Ruth ; Manglik, Aashish ; Myers, Benjamin R.
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2021-04, Vol.19 (4), p.e3001191-e3001191
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Residue 6.43 defines receptor function in class F GPCRs
Author / Creator:Turku, Ainoleena ; Schihada, Hannes ; Kozielewicz, Pawel ; Bowin, Carl-Fredrik ; Schulte, Gunnar
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-06, Vol.12 (1), p.3919-3919, Article 3919
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State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures
Author / Creator:Espinosa-Bustos, Christian ; Mella, Jaime ; Soto-Delgado, Jorge ; Salas, Cristian O
Publisher:England: Future Science Ltd
Journal title:Future medicinal chemistry, 2019-03, Vol.11 (6), p.617-638
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Effects of Isoxazolyl Steroids on Key Genes of Sonic Hedgehog Cascade Expression in Tumor Cells
Author / Creator:Aleksandrova, Anna ; Mekhtiev, Arif ; Timoshenko, Olga ; Kugaevskaya, Elena ; Gureeva, Tatiana ; Gisina, Alisa ; Zavialova, Maria ; Scherbakov, Kirill ; Rudovich, Anton ; Zhabinskii, Vladimir ; Khripach, Vladimir
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-08, Vol.29 (17), p.4026
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Genetic landscape of meningioma
Author / Creator:Yuzawa, Sayaka ; Nishihara, Hiroshi ; Tanaka, Shinya
Publisher:Tokyo: Springer Japan
Journal title:Brain tumor pathology, 2016-10, Vol.33 (4), p.237-247
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A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo
Author / Creator:Zárate, Ana María ; Espinosa-Bustos, Christian ; Guerrero, Simón ; Fierro, Angélica ; Oyarzún-Ampuero, Felipe ; Quest, Andrew F. G. ; Di Marcotullio, Lucia ; Loricchio, Elena ; Caimano, Miriam ; Calcaterra, Andrea ; González-Quiroz, Matías ; Aguirre, Adam ; Meléndez, Jaime ; Salas, Cristian O.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-08, Vol.22 (16), p.8372
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ArticlesPeer ReviewedFull Text
Structure of the human smoothened receptor bound to an antitumour agent
Author / Creator:Wang, Chong ; Wu, Huixian ; Katritch, Vsevolod ; Han, Gye Won ; Huang, Xi-Ping ; Liu, Wei ; Siu, Fai Yiu ; Roth, Bryan L ; Cherezov, Vadim ; Stevens, Raymond C
Publisher:Nature Publishing Group
Journal title:Nature (London), 2013-05, Vol.497 (7449), p.338
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Structure of the human smoothened receptor 7TM bound to an antitumor agent
Author / Creator:Wang, Chong ; Wu, Huixian ; Katritch, Vsevolod ; Han, Gye Won ; Huang, Xi-Ping ; Liu, Wei ; Siu, Fai Yiu ; Roth, Bryan L. ; Cherezov, Vadim ; Stevens, Raymond C.
Journal title:Nature (London), 2013-05, Vol.497 (7449), p.338-343
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Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome
Author / Creator:Shi, Xiaoyu ; Garcia, Galo ; Van De Weghe, Julie C. ; McGorty, Ryan ; Pazour, Gregory J. ; Doherty, Dan ; Huang, Bo ; Reiter, Jeremy F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2017-10, Vol.19 (10), p.1178-1188
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Structure of the human smoothened receptor bound to an antitumour agent

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Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

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Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand

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A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury

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Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination

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Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

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Structure‐Activity Relationship Studies of Hydantoin‐Cored Ligands for Smoothened Receptor

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Cyclopamine modulates smoothened receptor activity in a binding position dependent manner

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Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

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Cholesterol access in cellular membranes controls Hedgehog signaling

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Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats

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Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

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Residue 6.43 defines receptor function in class F GPCRs

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State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures

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Effects of Isoxazolyl Steroids on Key Genes of Sonic Hedgehog Cascade Expression in Tumor Cells

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Genetic landscape of meningioma

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A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo

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Structure of the human smoothened receptor bound to an antitumour agent

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Structure of the human smoothened receptor 7TM bound to an antitumor agent

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Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome

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