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502 results for Sphingosine+-+pharmacology

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ArticlesPeer ReviewedFull Text
FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P₁) modulation
Author / Creator:Choi, Ji Woong ; Gardell, Shannon E ; Herr, Deron R ; Rivera, Richard ; Lee, Chang-Wook ; Noguchi, Kyoko ; Teo, Siew Teng ; Yung, Yun C ; Lu, Melissa ; Kennedy, Grace ; Chun, Jerold
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-01, Vol.108 (2), p.751-756
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Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial
Author / Creator:Calabresi, Peter A, Dr ; Radue, Ernst-Wilhelm, Prof ; Goodin, Douglas, MD ; Jeffery, Douglas, MD ; Rammohan, Kottil W, MD ; Reder, Anthony T, MD ; Vollmer, Timothy, MD ; Agius, Mark A, MD ; Kappos, Ludwig, Prof ; Stites, Tracy, PhD ; Li, Bingbing, PhD ; Cappiello, Linda, MD ; von Rosenstiel, Philipp, MD ; Lublin, Fred D, MD
Publisher:England: Elsevier Ltd
Journal title:Lancet neurology, 2014-06, Vol.13 (6), p.545-556
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Perfused 3D angiogenic sprouting in a high-throughput in vitro platform
Author / Creator:van Duinen, V. ; Zhu, D. ; Ramakers, C. ; van Zonneveld, A. J. ; Vulto, P. ; Hankemeier, T.
Publisher:Dordrecht: Springer Netherlands
Journal title:Angiogenesis (London), 2019-02, Vol.22 (1), p.157-165
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Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro
Author / Creator:Nguyen, Duc-Huy T. ; Stapleton, Sarah C. ; Yang, Michael T. ; Cha, Susie S. ; Choi, Colin K. ; Galie, Peter A. ; Chen, Christopher S.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-04, Vol.110 (17), p.6712-6717
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A regenerative approach to the treatment of multiple sclerosis
Author / Creator:Deshmukh, Vishal A. ; Tardif, Virginie ; Lyssiotis, Costas A. ; Green, Chelsea C. ; Kerman, Bilal ; Kim, Hyung Joon ; Padmanabhan, Krishnan ; Swoboda, Jonathan G. ; Ahmad, Insha ; Kondo, Toru ; Gage, Fred H. ; Theofilopoulos, Argyrios N. ; Lawson, Brian R. ; Schultz, Peter G. ; Lairson, Luke L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-10, Vol.502 (7471), p.327-332
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Cardiac and vascular effects of fingolimod: Mechanistic basis and clinical implications
Author / Creator:Camm, John, MD ; Hla, Timothy, PhD ; Bakshi, Rajesh, MD ; Brinkmann, Volker, PhD
Publisher:United States: Elsevier Inc
Journal title:The American heart journal, 2014-11, Vol.168 (5), p.632-644
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Fingolimod for Multiple Sclerosis
Author / Creator:Pelletier, Daniel ; Hafler, David A
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2012-01, Vol.366 (4), p.339-347
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Mechanical tugging force regulates the size of cell-cell junctions
Author / Creator:Liu, Zhijun ; Tan, John L ; Cohen, Daniel M ; Yang, Michael T ; Sniadecki, Nathan J ; Ruiz, Sami Alom ; Nelson, Celeste M ; Chen, Christopher S
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (22), p.9944-9949
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ArticlesPeer ReviewedFull Text
Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory
Author / Creator:Hait, Nitai C ; Wise, Laura E ; Allegood, Jeremy C ; O'Brien, Megan ; Avni, Dorit ; Reeves, Thomas M ; Knapp, Pamela E ; Lu, Junyan ; Luo, Cheng ; Miles, Michael F ; Milstien, Sheldon ; Lichtman, Aron H ; Spiegel, Sarah
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2014-07, Vol.17 (7), p.971-980
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ArticlesPeer ReviewedFull Text
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
Author / Creator:Neviani, Paolo ; Harb, Jason G ; Oaks, Joshua J ; Santhanam, Ramasamy ; Walker, Christopher J ; Ellis, Justin J ; Ferenchak, Gregory ; Dorrance, Adrienne M ; Paisie, Carolyn A ; Eiring, Anna M ; Ma, Yihui ; Mao, Hsiaoyin C ; Zhang, Bin ; Wunderlich, Mark ; May, Philippa C ; Sun, Chaode ; Saddoughi, Sahar A ; Bielawski, Jacek ; Blum, William ; Klisovic, Rebecca B ; Solt, Janelle A ; Byrd, John C ; Volinia, Stefano ; Cortes, Jorge ; Huettner, Claudia S ; Koschmieder, Steffen ; Holyoake, Tessa L ; Devine, Steven ; Caligiuri, Michael A ; Croce, Carlo M ; Garzon, Ramiro ; Ogretmen, Besim ; Arlinghaus, Ralph B ; Chen, Ching-Shih ; Bittman, Robert ; Hokland, Peter ; Roy, Denis-Claude ; Milojkovic, Dragana ; Apperley, Jane ; Goldman, John M ; Reid, Alistair ; Mulloy, James C ; Bhatia, Ravi ; Marcucci, Guido ; Perrotti, Danilo
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2013-10, Vol.123 (10), p.4144-4157
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ArticlesPeer ReviewedFull Text
Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress
Author / Creator:Arnon, Tal I. ; Horton, Robert M. ; Grigorova, Irina L. ; Cyster, Jason G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-01, Vol.493 (7434), p.684-688
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Finding a way out: lymphocyte egress from lymphoid organs
Author / Creator:Schwab, Susan R ; Cyster, Jason G
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2007-12, Vol.8 (12), p.1295-1301
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Pericytes enable effective angiogenesis in the presence of proinflammatory signals
Author / Creator:Kang, Tae-Yun ; Bocci, Federico ; Jolly, Mohit Kumar ; Levine, Herbert ; Onuchic, José Nelson ; Levchenko, Andre
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-11, Vol.116 (47), p.23551-23561
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ArticlesPeer ReviewedFull Text
Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome
Author / Creator:Deogracias, Rubén ; Yazdani, Morteza ; Dekkers, Martijn P. J ; Guy, Jacky ; Ionescu, Mihai Constantin S ; Vogt, Kaspar E ; Barde, Yves-Alain
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-08, Vol.109 (35), p.14230-14235
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ArticlesPeer ReviewedFull Text
Follicular shuttling of marginal zone B cells facilitates antigen transport
Author / Creator:Cinamon, Guy ; Zachariah, Marcus A ; Lam, Olivia M ; Foss, Frank W ; Cyster, Jason G
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2008-01, Vol.9 (1), p.54-62
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Sphingosine 1-Phosphate Activates S1PR3 to Induce a Proinflammatory Phenotype in Human Myometrial Cells
Author / Creator:Saurabh, Kumar ; Mbadhi, Magdaleena Naemi ; Prifti, Kevin K ; Martin, Kaci T ; Frolova, Antonina I
Publisher:US: Oxford University Press
Journal title:Endocrinology (Philadelphia), 2023-04, Vol.164 (6)
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Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors
Author / Creator:Mullershausen, Florian ; Zecri, Frédéric ; Cetin, Cihan ; Billich, Andreas ; Guerini, Danilo ; Seuwen, Klaus
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2009-06, Vol.5 (6), p.428-434
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Biologically active sphingolipids in cancer pathogenesis and treatment
Author / Creator:Ogretmen, Besim ; Hannun, Yusuf A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Cancer, 2004-08, Vol.4 (8), p.604-616
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Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis
Author / Creator:Ishii, Masaru ; Egen, Jackson G. ; Klauschen, Frederick ; Meier-Schellersheim, Martin ; Saeki, Yukihiko ; Vacher, Jean ; Proia, Richard L. ; Germain, Ronald N.
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2009-03, Vol.458 (7237), p.524-528
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Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice
Author / Creator:Oo, Myat Lin ; Chang, Sung-Hee ; Thangada, Shobha ; Wu, Ming-Tao ; Rezaul, Karim ; Blaho, Victoria ; Hwang, Sun-Il ; Han, David K ; Hla, Timothy
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2011-06, Vol.121 (6), p.2290-2300
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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P₁) modulation

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Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial

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Perfused 3D angiogenic sprouting in a high-throughput in vitro platform

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Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

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A regenerative approach to the treatment of multiple sclerosis

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Cardiac and vascular effects of fingolimod: Mechanistic basis and clinical implications

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Fingolimod for Multiple Sclerosis

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Mechanical tugging force regulates the size of cell-cell junctions

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Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

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PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

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Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress

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Finding a way out: lymphocyte egress from lymphoid organs

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Pericytes enable effective angiogenesis in the presence of proinflammatory signals

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Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

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Follicular shuttling of marginal zone B cells facilitates antigen transport

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Sphingosine 1-Phosphate Activates S1PR3 to Induce a Proinflammatory Phenotype in Human Myometrial Cells

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Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

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Biologically active sphingolipids in cancer pathogenesis and treatment

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Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

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Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice

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