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Newspaper ArticlesFull Text
SPILKER, MARY E
Publisher:Baltimore, Md: Tribune Publishing Company, LLC
Journal title:The Sun (Baltimore, Md. : 1837), 2013-03-28
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ArticlesPeer ReviewedFull Text
A Microfluidic Perfusion Platform for In Vitro Analysis of Drug Pharmacokinetic-Pharmacodynamic (PK-PD) Relationships
Author / Creator:Guerrero, Yadir A. ; Desai, Diti ; Sullivan, Connor ; Kindt, Erick ; Spilker, Mary E. ; Maurer, Tristan S. ; Solomon, Deepak E. ; Bartlett, Derek W.
Publisher:Cham: Springer International Publishing
Journal title:The AAPS journal, 2020-03, Vol.22 (2), p.53, Article 53
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ArticlesPeer ReviewedFull Text
Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities
Author / Creator:Bradshaw, Erica L. ; Spilker, Mary E. ; Zang, Richard ; Bansal, Loveleena ; He, Handan ; Jones, Rhys D.O. ; Le, Kha ; Penney, Mark ; Schuck, Edgar ; Topp, Brian ; Tsai, Alice ; Xu, Christine ; Nijsen, Marjoleen J.M.A. ; Chan, Jason R.
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2019-11, Vol.8 (11), p.777-791
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ArticlesPeer ReviewedFull Text
Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape
Author / Creator:Nijsen, Marjoleen J.M.A. ; Wu, Fan ; Bansal, Loveleena ; Bradshaw‐Pierce, Erica ; Chan, Jason R. ; Liederer, Bianca M. ; Mettetal, Jerome T. ; Schroeder, Patricia ; Schuck, Edgar ; Tsai, Alice ; Xu, Christine ; Chimalakonda, Anjaneya ; Le, Kha ; Penney, Mark ; Topp, Brian ; Yamada, Akihiro ; Spilker, Mary E.
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2018-03, Vol.7 (3), p.135-146
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ArticlesPeer ReviewedFull Text
Quantitative systems toxicology modeling in pharmaceutical research and development: An industry‐wide survey and selected case study examples
Author / Creator:Beattie, Kylie A. ; Verma, Meghna ; Brennan, Richard J. ; Clausznitzer, Diana ; Damian, Valeriu ; Leishman, Derek ; Spilker, Mary E. ; Boras, Britton ; Li, Zhenhong ; Oziolor, Elias ; Rieger, Theodore R. ; Sher, Anna
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2024-12, Vol.13 (12), p.2036-2051
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ArticlesPeer ReviewedFull Text
Metabolomics activity screening for identifying metabolites that modulate phenotype
Author / Creator:Guijas, Carlos ; Montenegro-Burke, J Rafael ; Warth, Benedikt ; Spilker, Mary E ; Siuzdak, Gary
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2018-04, Vol.36 (4), p.316-320
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ArticlesPeer ReviewedFull Text
A whole‐body circulatory neutrophil model with application to predicting clinical neutropenia from in vitro studies
Author / Creator:Chen, Wenbo ; Boras, Britton ; Sung, Tae ; Hu, Wenyue ; Spilker, Mary E. ; D’Argenio, David Z.
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2021-07, Vol.10 (7), p.671-683
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ArticlesPeer ReviewedFull Text
Predicting Chemotherapy-Induced Neutropenia and Granulocyte Colony–Stimulating Factor Response Using Model-Based In Vitro to Clinical Translation
Author / Creator:Chen, Wenbo ; Boras, Britton ; Sung, Tae ; Hu, Wenyue ; Spilker, Mary E. ; D’Argenio, David Z.
Publisher:Cham: Springer International Publishing
Journal title:The AAPS journal, 2020-11, Vol.22 (6), p.143-143, Article 143
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ArticlesPeer ReviewedFull Text
A physiological model of granulopoiesis to predict clinical drug induced neutropenia from in vitro bone marrow studies: with application to a cell cycle inhibitor
Author / Creator:Chen, Wenbo ; Boras, Britton ; Sung, Tae ; Yu, Yanke ; Zheng, Jenny ; Wang, Diane ; Hu, Wenyue ; Spilker, Mary E. ; D’Argenio, David Z.
Publisher:New York: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2020-04, Vol.47 (2), p.163-182
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ArticlesPeer ReviewedFull Text
Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids
Author / Creator:Kurczy, Michael E. ; Zhu, Zheng-Jiang ; Ivanisevic, Julijana ; Schuyler, Adam M. ; Lalwani, Kush ; Santidrian, Antonio F. ; David, John M. ; Giddabasappa, Anand ; Roberts, Amanda J. ; Olivos, Hernando J. ; O’Brien, Peter J. ; Franco, Lauren ; Fields, Matthew W. ; Paris, Liliana P. ; Friedlander, Martin ; Johnson, Caroline H. ; Epstein, Adrian A. ; Gendelman, Howard E. ; Wood, Malcolm R. ; Felding, Brunhilde H. ; Patti, Gary J. ; Spilker, Mary E. ; Siuzdak, Gary
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-01, Vol.6 (1), p.5998-5998, Article 5998
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ArticlesPeer ReviewedFull Text
The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models
Author / Creator:Palsson, Sirus ; Hickling, Timothy P ; Bradshaw-Pierce, Erica L ; Zager, Michael ; Jooss, Karin ; O'Brien, Peter J ; Spilker, Mary E ; Palsson, Bernhard O ; Vicini, Paolo
Publisher:England: BioMed Central Ltd
Journal title:BMC systems biology, 2013-09, Vol.7 (1), p.95-95, Article 95
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ArticlesPeer ReviewedFull Text
Comparison of Statistical Data Models for Identifying Differentially Expressed Genes Using a Generalized Likelihood Ratio Test
Author / Creator:Seng, Kok-Yong ; Glenny, Robb W. ; Madtes, David K. ; Spilker, Mary E. ; Vicini, Paolo ; Gharib, Sina A.
Publisher:London, England: SAGE Publishing
Journal title:Gene regulation and systems biology, 2008-01, Vol.2008 (2), p.125-139
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ArticlesPeer ReviewedFull Text
Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging
Author / Creator:O'Brien, Peter J ; Lee, Michelle ; Spilker, Mary E ; Zhang, Cathy C ; Yan, Zhengming ; Nichols, Timothy C ; Li, Wenlin ; Johnson, Caroline H ; Patti, Gary J ; Siuzdak, Gary
Publisher:England: BioMed Central Ltd
Journal title:Cancer & metabolism, 2013-01, Vol.1 (1), p.4-4, Article 4
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ArticlesPeer ReviewedFull Text
Kinetic modelling of [11C]flumazenil using data-driven methods
Author / Creator:Miederer, Isabelle ; Ziegler, Sibylle I. ; Liedtke, Christoph ; Spilker, Mary E. ; Miederer, Matthias ; Sprenger, Till ; Wagner, Klaus J. ; Drzezga, Alexander ; Boecker, Henning
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:European journal of nuclear medicine and molecular imaging, 2009-04, Vol.36 (4), p.659-670
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ArticlesPeer ReviewedFull Text
Kinetic modeling of contrast-enhanced MRI: an automated technique for assessing inflammation in the rheumatoid arthritis wrist
Author / Creator:Zierhut, Matthew L ; Gardner, Jill C ; Spilker, Mary E ; Sharp, John T ; Vicini, Paolo
Publisher:United States: Springer Nature B.V
Journal title:Annals of biomedical engineering, 2007-05, Vol.35 (5), p.781-795
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ArticlesPeer ReviewedFull Text
Optimal Duration of PET Studies with ^sup 18^F-Fluoroethyl-Diprenorphine
Author / Creator:Boecker, Henning ; Sprenger, Till ; Henriksen, Gjermund ; Toelle, Thomas R ; Spilker, Mary E
Publisher:New York: Society of Nuclear Medicine
Journal title:The Journal of nuclear medicine (1978), 2005-12, Vol.46 (12), p.2092
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ArticlesPeer ReviewedFull Text
Optimal Duration of PET Studies with 18F-Fluoroethyl-Diprenorphine
Author / Creator:Boecker, Henning ; Sprenger, Till ; Henriksen, Gjermund ; Toelle, Thomas R ; Spilker, Mary E
Publisher:United States: Soc Nuclear Med
Journal title:The Journal of nuclear medicine (1978), 2005-12, Vol.46 (12), p.2092-2096
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ArticlesPeer ReviewedFull Text
Quantification of [ 18F]diprenorphine kinetics in the human brain with compartmental and non-compartmental modeling approaches
Author / Creator:Spilker, Mary E ; Sprenger, Till ; Valet, Michael ; Henriksen, Gjermund ; Wagner, Klaus ; Wester, Hans-J ; Toelle, Thomas R ; Boecker, Henning
Publisher:United States: Elsevier Inc
Journal title:NeuroImage (Orlando, Fla.), 2004-08, Vol.22 (4), p.1523-1533
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ArticlesPeer ReviewedFull Text
Comprehensive Bio-Imaging with Fluorinated Nanoparticles Using Breathable Liquids
Author / Creator:Kurczy, Michael E. ; Zhu, Zheng Jiang ; Ivanisevic, Julijana ; Schuyler, Adam M. ; Lalwani, Kush ; Santidrian, Antonio F. ; David, John W. ; Giddabasappa, Anand ; Roberts, Amanda ; Olivos, Hernando J. ; O'Brien, Peter J. ; Franco, Lauren ; Fields, Matthew W. ; Paris, Liliana P. ; Friedlander, Martin ; Johnson, Caroline H. ; Epstein, Adrian ; Gendleman, Howard E. ; Wood, Malcolm ; Felding-Habermann, Brunhilde ; Patti, Gary J. ; Spilker, Mary E. ; Siuzdak, Gary
Journal title:Nature communications, 2015-01, Vol.6, p.5998-5998
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ArticlesPeer ReviewedFull Text
Biodistribution and Pharmacokinetics of the {alpha}v{beta}3-Selective Tracer 18F-Galacto-RGD in Cancer Patients
Author / Creator:Beer, Ambros J ; Haubner, Roland ; Goebel, Michael ; Luderschmidt, Stephan ; Spilker, Mary E ; Wester, Hans-Jurgen ; Weber, Wolfgang A ; Schwaiger, Markus
Publisher:Soc Nuclear Med
Journal title:The Journal of nuclear medicine (1978), 2005-08, Vol.46 (8), p.1333
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SPILKER, MARY E

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A Microfluidic Perfusion Platform for In Vitro Analysis of Drug Pharmacokinetic-Pharmacodynamic (PK-PD) Relationships

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Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities

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Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape

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Quantitative systems toxicology modeling in pharmaceutical research and development: An industry‐wide survey and selected case study examples

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Metabolomics activity screening for identifying metabolites that modulate phenotype

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A whole‐body circulatory neutrophil model with application to predicting clinical neutropenia from in vitro studies

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Predicting Chemotherapy-Induced Neutropenia and Granulocyte Colony–Stimulating Factor Response Using Model-Based In Vitro to Clinical Translation

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A physiological model of granulopoiesis to predict clinical drug induced neutropenia from in vitro bone marrow studies: with application to a cell cycle inhibitor

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Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids

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The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models

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Comparison of Statistical Data Models for Identifying Differentially Expressed Genes Using a Generalized Likelihood Ratio Test

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Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging

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Kinetic modelling of [11C]flumazenil using data-driven methods

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Kinetic modeling of contrast-enhanced MRI: an automated technique for assessing inflammation in the rheumatoid arthritis wrist

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Optimal Duration of PET Studies with ^sup 18^F-Fluoroethyl-Diprenorphine

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Optimal Duration of PET Studies with 18F-Fluoroethyl-Diprenorphine

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Quantification of [ 18F]diprenorphine kinetics in the human brain with compartmental and non-compartmental modeling approaches

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Comprehensive Bio-Imaging with Fluorinated Nanoparticles Using Breathable Liquids

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Biodistribution and Pharmacokinetics of the {alpha}v{beta}3-Selective Tracer 18F-Galacto-RGD in Cancer Patients

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