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ArticlesPeer ReviewedFull Text
Standing the test of time: targeting thymidylate biosynthesis in cancer therapy
Author / Creator:Wilson, Peter M. ; Danenberg, Peter V. ; Johnston, Patrick G. ; Lenz, Heinz-Josef ; Ladner, Robert D.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Clinical oncology, 2014-05, Vol.11 (5), p.282-298
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ArticlesPeer ReviewedFull Text
Folate rescues vitamin B 12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability
Author / Creator:Palmer, Ashley M. ; Kamynina, Elena ; Field, Martha S. ; Stover, Patrick J.
Publisher:United States
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-05, Vol.114 (20), p.E4095
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ArticlesPeer ReviewedFull Text
Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria
Author / Creator:Anderson, Donald D ; Quintero, Cynthia M ; Stover, Patrick J
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (37), p.15163-15168
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ArticlesPeer ReviewedFull Text
An unprecedented mechanism of nucleotide methylation in organisms containing thyX
Author / Creator:Mishanina, Tatiana V. ; Yu, Liping ; Karunaratne, Kalani ; Mondal, Dibyendu ; Corcoran, John M. ; Choi, Michael A. ; Kohen, Amnon
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2016-01, Vol.351 (6272), p.507-510
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ArticlesPeer ReviewedFull Text
Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis
Author / Creator:Field, Martha S. ; Kamynina, Elena ; Watkins, David ; Rosenblatt, David S. ; Stover, Patrick J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (2), p.400-405
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ArticlesPeer ReviewedFull Text
Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis
Author / Creator:Kamynina, Elena ; Lachenauer, Erica R. ; DiRisio, Aislyn C. ; Liebenthal, Rebecca P. ; Field, Martha S. ; Stover, Patrick J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (12), p.E2319-E2326
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ArticlesPeer ReviewedFull Text
Flavin-Dependent Thymidylate Synthase as a New Antibiotic Target
Author / Creator:Choi, Michael ; Karunaratne, Kalani ; Kohen, Amnon
Publisher:Switzerland: MDPI
Journal title:Molecules (Basel, Switzerland), 2016-05, Vol.21 (5), p.654
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ArticlesPeer ReviewedFull Text
An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene
Author / Creator:Koehn, Eric M. ; Fleischmann, Todd ; Conrad, John A. ; Palfey, Bruce A. ; Lesley, Scott A. ; Mathews, Irimpan I. ; Kohen, Amnon
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2009-04, Vol.458 (7240), p.919-923
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ArticlesPeer ReviewedFull Text
An Alternative Flavin-Dependent Mechanism for Thymidylate Synthesis
Author / Creator:Myllykallio, Hannu ; Lipowski, Gerard ; Leduc, Damien ; Filee, Jonathan ; Forterre, Patrick ; Liebl, Ursula
Publisher:Washington, DC: American Society for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2002-07, Vol.297 (5578), p.105-107
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ArticlesPeer ReviewedFull Text
Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based t...
Author / Creator:Wang, Liya ; Sun, Ren ; Eriksson, Staffan
Publisher:England: BioMed Central Ltd
Journal title:BMC cell biology, 2020-04, Vol.21 (1), p.33-33, Article 33
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ArticlesPeer ReviewedFull Text
Anti-folate combination therapies and their effect on the development of drug resistance in Plasmodium vivax
Author / Creator:Ding, Shuai ; Ye, Run ; Zhang, Dongmei ; Sun, Xiaodong ; Zhou, Hongning ; McCutchan, Thomas F. ; Pan, Weiqing
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2013-01, Vol.3 (1), p.1008-1008, Article 1008
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ArticlesPeer ReviewedFull Text
Contribution of Cytidine Deaminase to Thymidylate Biosynthesis in Trypanosoma brucei: Intracellular Localization and Properties of the Enzyme
Author / Creator:Moro-Bulnes, Ana ; Castillo-Acosta, Víctor M. ; Valente, Maria ; Carrero-Lérida, Juana ; Pérez-Moreno, Guiomar ; Ruiz-Pérez, Luis Miguel ; González-Pacanowska, Dolores
Publisher:United States: American Society for Microbiology
Journal title:mSphere, 2019-08, Vol.4 (4)
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ArticlesPeer ReviewedFull Text
Folate supplementation differently affects uracil content in DNA in the mouse colon and liver
Author / Creator:Kim, Kyong-Chol ; Jang, Hyeran ; Sauer, Julia ; Zimmerly, Ella M. ; Liu, Zhenhua ; Chanson, Aurelie ; Smith, Donald E. ; Friso, Simonetta ; Choi, Sang-Woon
Publisher:Cambridge, UK: Cambridge University Press
Journal title:British journal of nutrition, 2011-03, Vol.105 (5), p.688-693
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ArticlesPeer ReviewedFull Text
Biochemistry: Anchors away
Author / Creator:Costi, Maria Paola ; Ferrari, Stefania
Publisher:England
Journal title:Nature (London), 2009-04, Vol.458 (7240), p.840-841
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ArticlesPeer ReviewedFull Text
Developmental arrest in Caenorhabditis elegans dauer larvae causes high expression of enzymes involved in thymidylate biosynthesis, similar to that found in Trichinella muscle larvae
Author / Creator:WIŃSKA, P. ; GOŁOS, B. ; CIEŚLA, J. ; ZIELIŃSKI, Z. ; FRĄCZYK, T. ; WAŁAJTYS-RODE, E. ; RODE, W.
Publisher:Cambridge, UK: Cambridge University Press
Journal title:Parasitology, 2005-08, Vol.131 (2), p.247-254
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ArticlesPeer ReviewedFull Text
Mild Methionine Excess Does Not Affect Thymidylate Synthesis or Inflammation Markers Expression in Human Aortic Endothelial Cells
Author / Creator:Achón, María ; Alonso-Aperte, Elena ; Varela-Moreiras, Gregorio ; Selhub, Jacob
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Annals of nutrition and metabolism, 2009-01, Vol.54 (1), p.28-34
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ArticlesPeer ReviewedFull Text
Biochemistry. DNA building block reinvented
Author / Creator:Murzin, Alexey G
Publisher:United States
Journal title:Science (American Association for the Advancement of Science), 2002-07, Vol.297 (5578), p.61-62
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ArticlesPeer ReviewedFull Text
γ -fluoromethotrexate: Synthesis and Biological Activity of a Potent Inhibitor of Dihydrofolate Reductase with Greatly Diminished Ability to Form poly-γ -glutamates
Author / Creator:Galivan, John ; Inglese, James ; McGuire, John J. ; Nimec, Zenia ; Coward, James K.
Publisher:Washington, DC: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 1985-05, Vol.82 (9), p.2598-2602
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Standing the test of time: targeting thymidylate biosynthesis in cancer therapy

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Folate rescues vitamin B 12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability

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Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria

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An unprecedented mechanism of nucleotide methylation in organisms containing thyX

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Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis

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Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis

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Flavin-Dependent Thymidylate Synthase as a New Antibiotic Target

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An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

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An Alternative Flavin-Dependent Mechanism for Thymidylate Synthesis

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Basic biochemical characterization of cytosolic enzymes in thymidine nucleotide synthesis in adult rat tissues: implications for tissue specific mitochondrial DNA depletion and deoxynucleoside-based t...

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Anti-folate combination therapies and their effect on the development of drug resistance in Plasmodium vivax

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Contribution of Cytidine Deaminase to Thymidylate Biosynthesis in Trypanosoma brucei: Intracellular Localization and Properties of the Enzyme

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Folate supplementation differently affects uracil content in DNA in the mouse colon and liver

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Biochemistry: Anchors away

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Developmental arrest in Caenorhabditis elegans dauer larvae causes high expression of enzymes involved in thymidylate biosynthesis, similar to that found in Trichinella muscle larvae

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Mild Methionine Excess Does Not Affect Thymidylate Synthesis or Inflammation Markers Expression in Human Aortic Endothelial Cells

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Biochemistry. DNA building block reinvented

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γ -fluoromethotrexate: Synthesis and Biological Activity of a Potent Inhibitor of Dihydrofolate Reductase with Greatly Diminished Ability to Form poly-γ -glutamates

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