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Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study
Author / Creator:Varma, Vijay R ; Oommen, Anup M ; Varma, Sudhir ; Casanova, Ramon ; An, Yang ; Andrews, Ryan M ; O'Brien, Richard ; Pletnikova, Olga ; Troncoso, Juan C ; Toledo, Jon ; Baillie, Rebecca ; Arnold, Matthias ; Kastenmueller, Gabi ; Nho, Kwangsik ; Doraiswamy, P Murali ; Saykin, Andrew J ; Kaddurah-Daouk, Rima ; Legido-Quigley, Cristina ; Thambisetty, Madhav
Publisher:United States: Public Library of Science
Journal title:PLoS medicine, 2018-01, Vol.15 (1), p.e1002482
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Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study
Author / Creator:Mahajan, Uma V ; Varma, Vijay R ; Griswold, Michael E ; Blackshear, Chad T ; An, Yang ; Oommen, Anup M ; Varma, Sudhir ; Troncoso, Juan C ; Pletnikova, Olga ; O'Brien, Richard ; Hohman, Timothy J ; Legido-Quigley, Cristina ; Thambisetty, Madhav
Publisher:United States: Public Library of Science
Journal title:PLoS medicine, 2020-01, Vol.17 (1), p.e1003012-e1003012
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Scalar on time-by-distribution regression and its application for modelling associations between daily-living physical activity and cognitive functions in Alzheimer’s Disease
Author / Creator:Ghosal, Rahul ; Varma, Vijay R. ; Volfson, Dmitri ; Urbanek, Jacek ; Hausdorff, Jeffrey M. ; Watts, Amber ; Zipunnikov, Vadim
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-07, Vol.12 (1), p.11558-16, Article 11558
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Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease
Author / Creator:Varma, Vijay R. ; Desai, Rishi J. ; Navakkode, Sheeja ; Wong, Lik-Wei ; Anerillas, Carlos ; Loeffler, Tina ; Schilcher, Irene ; Mahesri, Mufaddal ; Chin, Kristyn ; Horton, Daniel B. ; Kim, Seoyoung C. ; Gerhard, Tobias ; Segal, Jodi B. ; Schneeweiss, Sebastian ; Gorospe, Myriam ; Sajikumar, Sreedharan ; Thambisetty, Madhav
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2023-03, Vol.28 (3), p.1312-1326
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Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study
Author / Creator:Varma, Vijay R ; Wang, Youjin ; An, Yang ; Varma, Sudhir ; Bilgel, Murat ; Doshi, Jimit ; Legido-Quigley, Cristina ; Delgado, João C ; Oommen, Anup M ; Roberts, Jackson A ; Wong, Dean F ; Davatzikos, Christos ; Resnick, Susan M ; Troncoso, Juan C ; Pletnikova, Olga ; O'Brien, Richard ; Hak, Eelko ; Baak, Brenda N ; Pfeiffer, Ruth ; Baloni, Priyanka ; Mohmoudiandehkordi, Siamak ; Nho, Kwangsik ; Kaddurah-Daouk, Rima ; Bennett, David A ; Gadalla, Shahinaz M ; Thambisetty, Madhav
Publisher:United States: Public Library of Science
Journal title:PLoS medicine, 2021-05, Vol.18 (5), p.e1003615-e1003615
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Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study of Aging (BLSA) and the Tsuruoka Metabolomics Cohort St...
Author / Creator:Roberts, Jackson A ; Varma, Vijay R ; Huang, Chiung-Wei ; An, Yang ; Oommen, Anup ; Tanaka, Toshiko ; Ferrucci, Luigi ; Elango, Palchamy ; Takebayashi, Toru ; Harada, Sei ; Iida, Miho ; Thambisetty, Madhav
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2020-02, Vol.21 (4), p.1249
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ArticlesPeer ReviewedFull Text
Correction: Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study
Author / Creator:Mahajan, Uma V ; Varma, Vijay R ; Griswold, Michael E ; Blackshear, Chad T ; An, Yang ; Oommen, Anup M ; Varma, Sudhir ; Troncoso, Juan C ; Pletnikova, Olga ; O'Brien, Richard ; Hohman, Timothy J ; Legido-Quigley, Cristina ; Thambisetty, Madhav
Publisher:San Francisco, CA USA: Public Library of Science
Journal title:PLoS medicine, 2020-10, Vol.17 (10), p.e1003439-e1003439
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Blood Metabolite Signatures of Metabolic Syndrome in Two Cross-Cultural Older Adult Cohorts
Author / Creator:Mahajan, Uma V ; Varma, Vijay R ; Huang, Chiung-Wei ; An, Yang ; Tanaka, Toshiko ; Ferrucci, Luigi ; Takebayashi, Toru ; Harada, Sei ; Iida, Miho ; Legido-Quigley, Cristina ; Thambisetty, Madhav
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2020-02, Vol.21 (4), p.1324
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ArticlesPeer ReviewedFull Text
Continuous gait monitoring discriminates community‐dwelling mild Alzheimer's disease from cognitively normal controls
Author / Creator:Varma, Vijay R. ; Ghosal, Rahul ; Hillel, Inbar ; Volfson, Dmitri ; Weiss, Jordan ; Urbanek, Jacek ; Hausdorff, Jeffrey M. ; Zipunnikov, Vadim ; Watts, Amber
Publisher:United States: John Wiley & Sons, Inc
Journal title:Alzheimer's & dementia : translational research & clinical interventions, 2021, Vol.7 (1), p.e12131-n/a
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Targeting abnormal metabolism in Alzheimer's disease: The Drug Repurposing for Effective Alzheimer's Medicines (DREAM) study
Author / Creator:Desai, Rishi J. ; Varma, Vijay R. ; Gerhard, Tobias ; Segal, Jodi ; Mahesri, Mufaddal ; Chin, Kristyn ; Nonnenmacher, Edward ; Gabbeta, Avinash ; Mammen, Anup M. ; Varma, Sudhir ; Horton, Daniel B. ; Kim, Seoyoung C. ; Schneeweiss, Sebastian ; Thambisetty, Madhav
Publisher:United States: John Wiley & Sons, Inc
Journal title:Alzheimer's & dementia : translational research & clinical interventions, 2020, Vol.6 (1), p.e12095-n/a
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Biological sex and DNA repair deficiency drive Alzheimer’s disease via systemic metabolic remodeling and brain mitochondrial dysfunction
Author / Creator:Demarest, Tyler G. ; Varma, Vijay R. ; Estrada, Darlene ; Babbar, Mansi ; Basu, Sambuddha ; Mahajan, Uma V. ; Moaddel, Ruin ; Croteau, Deborah L. ; Thambisetty, Madhav ; Mattson, Mark P. ; Bohr, Vilhelm A.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2020-07, Vol.140 (1), p.25-47
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ArticlesFull Text
Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study
Author / Creator:Varma, Vijay R. ; Büşra Lüleci, H. ; Oommen, Anup M. ; Varma, Sudhir ; Blackshear, Chad T. ; Griswold, Michael E. ; An, Yang ; Roberts, Jackson A. ; O’Brien, Richard ; Pletnikova, Olga ; Troncoso, Juan C. ; Bennett, David A. ; Çakır, Tunahan ; Legido-Quigley, Cristina ; Thambisetty, Madhav
Publisher:London: Nature Publishing Group UK
Journal title:npj aging and mechanisms of disease, 2021-06, Vol.7 (1), p.11-11, Article 11
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ArticlesPeer ReviewedFull Text
Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer’s disease neuropathology
Author / Creator:Kac, Przemysław R. ; González-Ortiz, Fernando ; Emeršič, Andreja ; Dulewicz, Maciej ; Koutarapu, Srinivas ; Turton, Michael ; An, Yang ; Smirnov, Denis ; Kulczyńska-Przybik, Agnieszka ; Varma, Vijay R. ; Ashton, Nicholas J. ; Montoliu-Gaya, Laia ; Camporesi, Elena ; Winkel, Izabela ; Paradowski, Bogusław ; Moghekar, Abhay ; Troncoso, Juan C. ; Lashley, Tammaryn ; Brinkmalm, Gunnar ; Resnick, Susan M. ; Mroczko, Barbara ; Kvartsberg, Hlin ; Gregorič Kramberger, Milica ; Hanrieder, Jörg ; Čučnik, Saša ; Harrison, Peter ; Zetterberg, Henrik ; Lewczuk, Piotr ; Thambisetty, Madhav ; Rot, Uroš ; Galasko, Douglas ; Blennow, Kaj ; Karikari, Thomas K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-03, Vol.15 (1), p.2615-16, Article 2615
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Education is associated with sub-regions of the hippocampus and the amygdala vulnerable to neuropathologies of Alzheimer’s disease
Author / Creator:Tang, Xiaoying ; Varma, Vijay R. ; Miller, Michael I. ; Carlson, Michelle C.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Brain Structure and Function, 2017-04, Vol.222 (3), p.1469-1479
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Comparative Risk of Alzheimer Disease and Related Dementia Among Medicare Beneficiaries With Rheumatoid Arthritis Treated With Targeted Disease-Modifying Antirheumatic Agents
Author / Creator:Desai, Rishi J ; Varma, Vijay R ; Gerhard, Tobias ; Segal, Jodi ; Mahesri, Mufaddal ; Chin, Kristyn ; Horton, Daniel B ; Kim, Seoyoung C ; Schneeweiss, Sebastian ; Thambisetty, Madhav
Publisher:United States: American Medical Association
Journal title:JAMA network open, 2022-04, Vol.5 (4), p.e226567-e226567
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Serum Proteomic Signatures of Common Health Outcomes among Older Adults
Author / Creator:Roberts, Jackson A. ; Basu-Roy, Sayantani ; Shin, Jong ; Varma, Vijay R. ; Williamson, Andrew ; Blackshear, Chad ; Griswold, Michael E. ; Candia, Julián ; Elango, Palchamy ; Karikkineth, Ajoy C. ; Tanaka, Toshiko ; Ferrucci, Luigi ; Thambisetty, Madhav
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Gerontology (Basel), 2024-03, Vol.70 (3), p.269-278
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Unbiased proteomics and multivariable regularized regression techniques identify SMOC1, NOG, APCS, and NTN1 in an Alzheimer’s disease brain proteomic signature
Author / Creator:Roberts, Jackson A ; Varma, Vijay R ; Candia, Julián ; Tanaka, Toshiko ; Ferrucci, Luigi ; Bennett, David A ; Thambisetty, Madhav
Publisher:London: Nature Publishing Group
Journal title:npj aging and mechanisms of disease, 2023-07, Vol.9 (1), p.18
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ArticlesFull Text
Scalar on time-by-distribution regression and its application for modelling associations between daily-living physical activity and cognitive functions in Alzheimer's Disease
Author / Creator:Ghosal, Rahul ; Varma, Vijay R ; Volfson, Dmitri ; Urbanek, Jacek ; Hausdorff, Jeffrey M ; Watts, Amber ; Zipunnikov, Vadim
Publisher:Ithaca: Cornell University Library, arXiv.org
Journal title:arXiv.org, 2021-06
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Distributional data analysis via quantile functions and its application to modelling digital biomarkers of gait in Alzheimer's Disease
Author / Creator:Ghosal, Rahul ; Varma, Vijay R ; Volfson, Dmitri ; Inbar Hillel ; Urbanek, Jacek ; Hausdorff, Jeffrey M ; Watts, Amber ; Zipunnikov, Vadim
Publisher:Ithaca: Cornell University Library, arXiv.org
Journal title:arXiv.org, 2021-10
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ReportsFull Text
Serum Proteomic Signatures of Common Health Outcomes among Older Adults
Author / Creator:Roberts, Jackson A ; Basu-Roy, Sayantani ; Shin, Jong ; Varma, Vijay R ; Williamson, Andrew ; Blackshear, Chad ; Griswold, Michael E
Publisher:S. Karger AG
Journal title:Gerontology, 2024, Vol.70 (3), p.269
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Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

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Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study

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Scalar on time-by-distribution regression and its application for modelling associations between daily-living physical activity and cognitive functions in Alzheimer’s Disease

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Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease

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Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study

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Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study of Aging (BLSA) and the Tsuruoka Metabolomics Cohort St...

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Correction: Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study

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Blood Metabolite Signatures of Metabolic Syndrome in Two Cross-Cultural Older Adult Cohorts

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Continuous gait monitoring discriminates community‐dwelling mild Alzheimer's disease from cognitively normal controls

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Targeting abnormal metabolism in Alzheimer's disease: The Drug Repurposing for Effective Alzheimer's Medicines (DREAM) study

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Biological sex and DNA repair deficiency drive Alzheimer’s disease via systemic metabolic remodeling and brain mitochondrial dysfunction

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Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study

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Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer’s disease neuropathology

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Education is associated with sub-regions of the hippocampus and the amygdala vulnerable to neuropathologies of Alzheimer’s disease

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Comparative Risk of Alzheimer Disease and Related Dementia Among Medicare Beneficiaries With Rheumatoid Arthritis Treated With Targeted Disease-Modifying Antirheumatic Agents

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Serum Proteomic Signatures of Common Health Outcomes among Older Adults

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Unbiased proteomics and multivariable regularized regression techniques identify SMOC1, NOG, APCS, and NTN1 in an Alzheimer’s disease brain proteomic signature

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Scalar on time-by-distribution regression and its application for modelling associations between daily-living physical activity and cognitive functions in Alzheimer's Disease

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Distributional data analysis via quantile functions and its application to modelling digital biomarkers of gait in Alzheimer's Disease

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Serum Proteomic Signatures of Common Health Outcomes among Older Adults

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