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An electron transfer path connects subunits of a mycobacterial respiratory supercomplex
Author / Creator:Gong, Hongri ; Li, Jun ; Xu, Ao ; Tang, Yanting ; Ji, Wenxin ; Gao, Ruogu ; Wang, Shuhui ; Yu, Lu ; Tian, Changlin ; Li, Jingwen ; Yen, Hsin-Yung ; Man Lam, Sin ; Shui, Guanghou ; Yang, Xiuna ; Sun, Yuna ; Li, Xuemei ; Jia, Minze ; Yang, Cheng ; Jiang, Biao ; Lou, Zhiyong ; Robinson, Carol V ; Wong, Luet-Lok ; Guddat, Luke W ; Sun, Fei ; Wang, Quan ; Rao, Zihe
Publisher:United States: The American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2018-11, Vol.362 (6418)
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Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
Author / Creator:Urner, Leonhard H. ; Liko, Idlir ; Yen, Hsin-Yung ; Hoi, Kin-Kuan ; Bolla, Jani Reddy ; Gault, Joseph ; Almeida, Fernando Gonçalves ; Schweder, Marc-Philip ; Shutin, Denis ; Ehrmann, Svenja ; Haag, Rainer ; Robinson, Carol V. ; Pagel, Kevin
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-01, Vol.11 (1), p.564-564, Article 564
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Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization
Author / Creator:Bada Juarez, Juan F. ; Judge, Peter J. ; Adam, Suliman ; Axford, Danny ; Vinals, Javier ; Birch, James ; Kwan, Tristan O. C. ; Hoi, Kin Kuan ; Yen, Hsin-Yung ; Vial, Anthony ; Milhiet, Pierre-Emmanuel ; Robinson, Carol V. ; Schapiro, Igor ; Moraes, Isabel ; Watts, Anthony
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-01, Vol.12 (1), p.629-629, Article 629
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PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling
Author / Creator:Yen, Hsin-Yung ; Hoi, Kin Kuan ; Liko, Idlir ; Hedger, George ; Horrell, Michael R. ; Song, Wanling ; Wu, Di ; Heine, Philipp ; Warne, Tony ; Lee, Yang ; Carpenter, Byron ; Plückthun, Andreas ; Tate, Christopher G. ; Sansom, Mark S. P. ; Robinson, Carol V.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-07, Vol.559 (7714), p.423-427
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Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins
Author / Creator:Gault, Joseph ; Liko, Idlir ; Landreh, Michael ; Shutin, Denis ; Bolla, Jani Reddy ; Jefferies, Damien ; Agasid, Mark ; Yen, Hsin-Yung ; Ladds, Marcus J. G. W. ; Lane, David P. ; Khalid, Syma ; Mullen, Christopher ; Remes, Philip M. ; Huguet, Romain ; McAlister, Graeme ; Goodwin, Michael ; Viner, Rosa ; Syka, John E.P. ; Robinson, Carol V.
Publisher:New York: Nature Publishing Group US
Journal title:Nature methods, 2020-05, Vol.17 (5), p.505-508
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Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells
Author / Creator:Liu, Ying-Chih ; Yen, Hsin-Yung ; Chen, Chien-Yu ; Chen, Chein-Hung ; Cheng, Ping-Fu ; Juan, Yi-Hsiu ; Chen, Chung-Hsuan ; Khoo, Kay-Hooi ; Yu, Chong-Jen ; Yang, Pan-Chyr ; Hsu, Tsui-Ling ; Wong, Chi-Huey
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (28), p.11332-11337
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Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition
Author / Creator:Yen, Hsin-Yung ; Liu, Ying-Chih ; Chen, Nai-Yu ; Tsai, Chia-Feng ; Wang, Yi-Ting ; Chen, Yu-Ju ; Hsu, Tsui-Ling ; Yang, Pan-Chyr ; Wong, Chi-Huey
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-06, Vol.112 (22), p.6955-6960
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Ligand-induced conformational changes in the β1-adrenergic receptor revealed by hydrogen-deuterium exchange mass spectrometry
Author / Creator:Toporowska, Joanna ; Kapoor, Parth ; Musgaard, Maria ; Gherbi, Karolina ; Sengmany, Kathy ; Qu, Feng ; Soave, Mark ; Yen, Hsin-Yung ; Hansen, Kjetil ; Jazayeri, Ali ; Hopper, Jonathan T. S. ; Politis, Argyris
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-10, Vol.15 (1), p.8993-14, Article 8993
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Cell-permeable probe for identification and imaging of sialidases
Author / Creator:Tsai, Charng-Sheng ; Yen, Hsin-Yung ; Lin, Meng-I ; Tsai, Tsung-I ; Wang, Shi-Yun ; Huang, Wen-I ; Hsu, Tsui-Ling ; Cheng, Yih-Shyun E. ; Fang, Jim-Min ; Wong, Chi-Huey
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (7), p.2466-2471
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Phosphoproteomics Reveals HMGA1, a CK2 Substrate, as a Drug-Resistant Target in Non-Small Cell Lung Cancer
Author / Creator:Wang, Yi-Ting ; Pan, Szu-Hua ; Tsai, Chia-Feng ; Kuo, Ting-Chun ; Hsu, Yuan-Ling ; Yen, Hsin-Yung ; Choong, Wai-Kok ; Wu, Hsin-Yi ; Liao, Yen-Chen ; Hong, Tse-Ming ; Sung, Ting-Yi ; Yang, Pan-Chyr ; Chen, Yu-Ju
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-03, Vol.7 (1), p.44021-44021, Article 44021
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Structural insights into the lipid and ligand regulation of serotonin receptors
Author / Creator:Xu, Peiyu ; Huang, Sijie ; Zhang, Huibing ; Mao, Chunyou ; Zhou, X. Edward ; Cheng, Xi ; Simon, Icaro A. ; Shen, Dan-Dan ; Yen, Hsin-Yung ; Robinson, Carol V. ; Harpsøe, Kasper ; Svensson, Bo ; Guo, Jia ; Jiang, Hualiang ; Gloriam, David E. ; Melcher, Karsten ; Jiang, Yi ; Zhang, Yan ; Xu, H. Eric
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-04, Vol.592 (7854), p.469-473
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ArticlesPeer ReviewedFull Text
PtdIns(4,5)P 2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling
Author / Creator:Yen, Hsin-Yung ; Hoi, Kin Kuan ; Liko, Idlir ; Hedger, George ; Horrell, Michael R ; Song, Wanling ; Wu, Di ; Heine, Philipp ; Warne, Tony ; Lee, Yang ; Carpenter, Byron ; Plückthun, Andreas ; Tate, Christopher G ; Sansom, Mark S P ; Robinson, Carol V
Publisher:England
Journal title:Nature (London), 2018-07, Vol.559 (7714), p.423
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Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics
Author / Creator:Tsai, Chia-Feng ; Wang, Yi-Ting ; Yen, Hsin-Yung ; Tsou, Chih-Chiang ; Ku, Wei-Chi ; Lin, Pei-Yi ; Chen, Hsuan-Yu ; Nesvizhskii, Alexey I. ; Ishihama, Yasushi ; Chen, Yu-Ju
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-03, Vol.6 (1), p.6622-6622, Article 6622
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Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor
Author / Creator:Yen, Hsin-Yung ; Liko, Idlir ; Song, Wanling ; Kapoor, Parth ; Almeida, Fernando ; Toporowska, Joanna ; Gherbi, Karolina ; Hopper, Jonathan T. S. ; Charlton, Steven J. ; Politis, Argyris ; Sansom, Mark S. P. ; Jazayeri, Ali ; Robinson, Carol V.
Publisher:London: Nature Publishing Group UK
Journal title:Nature chemistry, 2022-12, Vol.14 (12), p.1375-1382
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Ligand-induced conformational changes in the β1-Adrenergic Receptor Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry
Author / Creator:Toporowska, Joanna ; Kapoor, Parth ; Musgaard, Maria ; Gherbi, Karolina ; Sengmany, Kathy ; Qu, Feng ; Soave, Mark ; Hsin-Yung Yen ; Hansen, Kjetil ; Jazayeri, Ali ; Hopper, Jonathan Ts ; Politis, Argyris
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2024-02
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PtdIns
Author / Creator:Yen, Hsin-Yung ; Hoi, Kin Kuan ; Liko, Idlir ; Hedger, George ; Horrell, Michael R ; Song, Wanling ; Wu, Di
Publisher:Nature Publishing Group
Journal title:Nature (London), 2018-07, Vol.559 (7714), p.423
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PtdInsP.sub.2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling
Author / Creator:Yen, Hsin-Yung ; Hoi, Kin Kuan ; Liko, Idlir ; Hedger, George ; Horrell, Michael R ; Song, Wanling ; Wu, Di
Publisher:Nature Publishing Group
Journal title:Nature (London), 2018-07, Vol.559 (7714), p.423
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Identification of PTGR2 inhibitors as a new therapy for diabetes and obesity
Author / Creator:Yi-Cheng, Chang ; Meng-Lun Hsieh ; Hsiao-Lin, Lee ; Siow-Wey Hee ; Chi-Fon Chang ; Hsin-Yung Yen ; Yi-An, Chen ; Yet-Ran Chen ; Ya-Wen Chou ; Fu-An, Li ; Yi-Yu, Ke ; Shih-Yi, Chen ; Ming-Shiu, Hung ; Alfur Fu-Hsin Hung ; Jing-Yong, Huang ; Chu-Hsuan Chiu ; Shih-Yao, Lin ; Sheue-Fang Shih ; Hsu, Chih-Neng ; Hwang, Juey-Jen ; Teng-Kuang Yeh ; Ting-Jen, Rachel Cheng ; Karen Chia-Wen Liao ; Liao, Daniel ; Lin, Shu-Wha ; Chen, Tzu-Yu ; Chun-Mei, Hu ; Vogel, Ulla Birgitte ; Saar, Daniel ; Kragelund, Birthe B ; Lun Kelvin Tsou ; Yu-Hua, Tseng ; Lee-Ming, Chuang
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2024-12
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Correlating glycoforms of DC-SIGN with stability using a combination of enzymatic digestion and ion mobility MS
Author / Creator:Hsin-Yung Yen ; Liko, Idlir ; Gault, Joseph ; Wu, Di ; Struwe, Weston B ; Robinson, Carol V
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2020-04
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PtdIns(4,5)P^sub 2^ stabilizes active states of GPCRs and enhances selectivity of G-protein coupling
Author / Creator:Yen, Hsin-Yung ; Hoi, Kin Kuan ; Liko, Idlir ; Hedger, George ; Horrell, Michael R ; Song, Wanling ; Wu, Di ; Heine, Philipp ; Warne, Tony ; Lee, Yang ; Carpenter, Byron ; Plückthun, Andreas ; Tate, Christopher G ; Sansom, Mark S P ; Robinson, Carol V
Publisher:London: Nature Publishing Group
Journal title:Nature (London), 2018-07, Vol.559 (7714), p.423-2
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An electron transfer path connects subunits of a mycobacterial respiratory supercomplex

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Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

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Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization

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PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

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Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins

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Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells

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Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition

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Ligand-induced conformational changes in the β1-adrenergic receptor revealed by hydrogen-deuterium exchange mass spectrometry

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Cell-permeable probe for identification and imaging of sialidases

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Phosphoproteomics Reveals HMGA1, a CK2 Substrate, as a Drug-Resistant Target in Non-Small Cell Lung Cancer

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Structural insights into the lipid and ligand regulation of serotonin receptors

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PtdIns(4,5)P 2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

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Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics

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Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor

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Ligand-induced conformational changes in the β1-Adrenergic Receptor Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry

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PtdIns

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PtdInsP.sub.2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

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Identification of PTGR2 inhibitors as a new therapy for diabetes and obesity

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Correlating glycoforms of DC-SIGN with stability using a combination of enzymatic digestion and ion mobility MS

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PtdIns(4,5)P^sub 2^ stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

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