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ArticlesPeer ReviewedFull Text
A mitochondria cluster at the proximal axon initial segment controls axodendritic TAU trafficking in rodent primary and human iPSC-derived neurons
Author / Creator:Tjiang, Noah ; Zempel, Hans
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2022-02, Vol.79 (2), p.120-120, Article 120
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Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia
Author / Creator:Zempel, Hans ; Mandelkow, Eva-Maria
Publisher:England: BioMed Central Ltd
Journal title:Molecular neurodegeneration, 2015-12, Vol.10 (67), p.68, Article 68
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Differential Effects of the Six Human TAU Isoforms: Somatic Retention of 2N-TAU and Increased Microtubule Number Induced by 4R-TAU
Author / Creator:Bachmann, Sarah ; Bell, Michael ; Klimek, Jennifer ; Zempel, Hans
Publisher:Lausanne: Frontiers Research Foundation
Journal title:Frontiers in neuroscience, 2021-05, Vol.15, p.643115-643115
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DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer's, Related Tauopathies and Genetic Tauopathies
Author / Creator:Zimmer-Bensch, Geraldine ; Zempel, Hans
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2021-11, Vol.10 (11), p.3064
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Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting
Author / Creator:Schützmann, Marie P. ; Hasecke, Filip ; Bachmann, Sarah ; Zielinski, Mara ; Hänsch, Sebastian ; Schröder, Gunnar F. ; Zempel, Hans ; Hoyer, Wolfgang
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-07, Vol.12 (1), p.4634-4634, Article 4634
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Understanding genetics, sex and signaling: Implications of sex-dependent APOE4-neutrophil-microglia interactions for Alzheimer’s and tauopathies
Author / Creator:Haag, Natja ; Bremer, Juliane ; Zempel, Hans
Publisher:London: Nature Publishing Group UK
Journal title:Signal transduction and targeted therapy, 2024-09, Vol.9 (1), p.252-3, Article 252
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Persistent astrocytic IL-3 stimulation of microglia slows disease in Alzheimer’s: treatment perspectives for Alzheimer’s
Author / Creator:Haag, Natja ; Zempel, Hans
Publisher:London: Nature Publishing Group UK
Journal title:Signal transduction and targeted therapy, 2021-11, Vol.6 (1), p.388-388, Article 388
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Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration
Author / Creator:Li, Xiaoyu ; Kumar, Yatender ; Zempel, Hans ; Mandelkow, Eva-Maria ; Biernat, Jacek ; Mandelkow, Eckhard
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2011-11, Vol.30 (23), p.4825-4837
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SH-SY5Y-derived neurons: a human neuronal model system for investigating TAU sorting and neuronal subtype-specific TAU vulnerability
Author / Creator:Bell, Michael ; Zempel, Hans
Publisher:Germany: De Gruyter
Journal title:Reviews in the neurosciences, 2022-01, Vol.33 (1), p.1-15
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The six brain‐specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes
Author / Creator:Buchholz, Sarah ; Zempel, Hans
Publisher:United States: John Wiley and Sons Inc
Journal title:Alzheimer's & dementia, 2024-05, Vol.20 (5), p.3606-3628
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Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin
Author / Creator:Zempel, Hans ; Luedtke, Julia ; Kumar, Yatender ; Biernat, Jacek ; Dawson, Hana ; Mandelkow, Eckhard ; Mandelkow, Eva-Maria
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2013-11, Vol.32 (22), p.2920-2937
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Linking Amyloid-β and Tau: Amyloid-β Induced Synaptic Dysfunction via Local Wreckage of the Neuronal Cytoskeleton
Author / Creator:Zempel, Hans ; Mandelkow, Eva-Maria
Publisher:Basel, Switzerland
Journal title:Neuro-degenerative diseases, 2012-01, Vol.10 (1-4), p.64-72
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ArticlesPeer ReviewedFull Text
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration
Author / Creator:Li, Xiaoyu ; Kumar, Yatender ; Zempel, Hans ; Mandelkow, Eva‐Maria ; Biernat, Jacek ; Mandelkow, Eckhard
Publisher:London: Nature Publishing Group UK
Journal title:The EMBO journal, 2011-11, Vol.30 (23), p.4825-4837
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DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical Neurons
Author / Creator:Bachmann, Sarah ; Linde, Jenice ; Bell, Michael ; Spehr, Marc ; Zempel, Hans ; Zimmer-Bensch, Geraldine
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2021-02, Vol.22 (4), p.2034
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The POLG Variant c.678G>C; p.(Gln226His) Is Associated with Mitochondrial Abnormalities in Fibroblasts Derived from a Patient Compared to a First-Degree Relative
Author / Creator:Mantey, Imra ; Langerscheidt, Felix ; Çakmak Durmaz, Çağla ; Baba, Naomi ; Burghardt, Katharina ; Karakaya, Mert ; Zempel, Hans
Publisher:Switzerland: MDPI AG
Journal title:Genes, 2025-02, Vol.16 (2), p.198
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ArticlesPeer ReviewedFull Text
The POLG Variant c.678GC; p. Is Associated with Mitochondrial Abnormalities in Fibroblasts Derived from a Patient Compared to a First-Degree Relative
Author / Creator:Mantey, Imra ; Langerscheidt, Felix ; Çakmak Durmaz, Çağla ; Baba, Naomi ; Burghardt, Katharina ; Karakaya, Mert ; Zempel, Hans
Publisher:MDPI AG
Journal title:Genes, 2025-02, Vol.16 (2)
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The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and phosphorylated tau-induced neuronal dysfunction
Author / Creator:Buchholz, Sarah ; Kabbani, Mohamed Aghyad Al ; Bell-Simons, Michael ; Kluge, Lena ; Cagmak, Cagla ; Klimek, Jennifer ; Haag, Natja ; Iohan, Lukas C ; Coulon, Audrey ; Costa, Marcos R ; Kilinc, Devrim ; Zempel, Hans
Publisher:United States
Journal title:Alzheimer's & dementia, 2025-02, p.e14403
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AAV-based gene therapy approaches for genetic forms of tauopathies and related neurogenetic disorders
Author / Creator:AGHYAD AL KABBANI, MOHAMED ; WUNDERLICH, GILBERT ; K鯤LER, CHRISTOPH ; ZEMPEL, HANS
Publisher:Mendoza: Tech Science Press
Journal title:Biocell, 2022, Vol.46 (4), p.847-853
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ArticlesPeer ReviewedFull Text
Linking Amyloid-[beta] and Tau: Amyloid-[beta] Induced Synaptic Dysfunction via Local Wreckage of the Neuronal Cytoskeleton
Author / Creator:Zempel, Hans ; Mandelkow, Eva-maria
Publisher:Basel: S. Karger AG
Journal title:Neuro-degenerative diseases, 2012-04, Vol.10 (1-4), p.64
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ArticlesPeer ReviewedFull Text
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin: Aβ causes microtubule severing by spastin via Tau
Author / Creator:Zempel, Hans ; Luedtke, Julia ; Kumar, Yatender ; Biernat, Jacek ; Dawson, Hana ; Mandelkow, Eckhard ; Mandelkow, Eva-Maria
Journal title:The EMBO journal, 2013-11, Vol.32 (22), p.2920-2937
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A mitochondria cluster at the proximal axon initial segment controls axodendritic TAU trafficking in rodent primary and human iPSC-derived neurons

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Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia

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Differential Effects of the Six Human TAU Isoforms: Somatic Retention of 2N-TAU and Increased Microtubule Number Induced by 4R-TAU

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DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer's, Related Tauopathies and Genetic Tauopathies

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Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting

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Understanding genetics, sex and signaling: Implications of sex-dependent APOE4-neutrophil-microglia interactions for Alzheimer’s and tauopathies

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Persistent astrocytic IL-3 stimulation of microglia slows disease in Alzheimer’s: treatment perspectives for Alzheimer’s

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Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

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SH-SY5Y-derived neurons: a human neuronal model system for investigating TAU sorting and neuronal subtype-specific TAU vulnerability

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The six brain‐specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes

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Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

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Linking Amyloid-β and Tau: Amyloid-β Induced Synaptic Dysfunction via Local Wreckage of the Neuronal Cytoskeleton

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Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

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DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical Neurons

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The POLG Variant c.678G>C; p.(Gln226His) Is Associated with Mitochondrial Abnormalities in Fibroblasts Derived from a Patient Compared to a First-Degree Relative

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The POLG Variant c.678GC; p. Is Associated with Mitochondrial Abnormalities in Fibroblasts Derived from a Patient Compared to a First-Degree Relative

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The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and phosphorylated tau-induced neuronal dysfunction

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AAV-based gene therapy approaches for genetic forms of tauopathies and related neurogenetic disorders

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Linking Amyloid-[beta] and Tau: Amyloid-[beta] Induced Synaptic Dysfunction via Local Wreckage of the Neuronal Cytoskeleton

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Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin: Aβ causes microtubule severing by spastin via Tau

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