Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau mi...
Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Amyloid-β peptide (Aβ) forms metastable oligomers >50 kDa, termed AβOs, that are more effective than Aβ amyloid fibrils at triggering Alzheimer’s disease-related processes such as synaptic dysfunction and Tau pathology, including Tau mislocalization. In neurons, Aβ accumulates in endo-lysosomal vesicles at low pH. Here, we show that the rate of AβO...
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Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting
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TN_cdi_doaj_primary_oai_doaj_org_article_b6f61d39315341c6800e49fcfe3a5b64
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b6f61d39315341c6800e49fcfe3a5b64
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24900-4
