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Structure and drug resistance of the Plasmodium falciparum transporter PfCRT
Author / Creator:Kim, Jonathan ; Tan, Yong Zi ; Wicht, Kathryn J. ; Erramilli, Satchal K. ; Dhingra, Satish K. ; Okombo, John ; Vendome, Jeremie ; Hagenah, Laura M. ; Giacometti, Sabrina I. ; Warren, Audrey L. ; Nosol, Kamil ; Roepe, Paul D. ; Potter, Clinton S. ; Carragher, Bridget ; Kossiakoff, Anthony A. ; Quick, Matthias ; Fidock, David A. ; Mancia, Filippo
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-12, Vol.576 (7786), p.315-320
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Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
Author / Creator:Ross, Leila S. ; Dhingra, Satish K. ; Mok, Sachel ; Yeo, Tomas ; Wicht, Kathryn J. ; Kümpornsin, Krittikorn ; Takala-Harrison, Shannon ; Witkowski, Benoit ; Fairhurst, Rick M. ; Ariey, Frederic ; Menard, Didier ; Fidock, David A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-08, Vol.9 (1), p.3314-13, Article 3314
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Plasmodium falciparum resistance to piperaquine driven by PfCRT
Author / Creator:Dhingra, Satish K ; Small-Saunders, Jennifer L ; Ménard, Didier ; Fidock, David A
Publisher:United States: Elsevier Ltd
Journal title:The Lancet infectious diseases, 2019-11, Vol.19 (11), p.1168-1169
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Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum
Author / Creator:Gabryszewski, Stanislaw J ; Charin Modchang ; Musset, Lise ; Chookajorn, Thanat ; Fidock, David A
Publisher:Oxford: Oxford University Press
Journal title:Molecular biology and evolution, 2016-06, Vol.33 (6), p.1554-1570
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Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt
Author / Creator:Pelleau, Stéphane ; Moss, Eli L. ; Dhingra, Satish K. ; Volney, Béatrice ; Casteras, Jessica ; Gabryszewski, Stanislaw J. ; Volkman, Sarah K. ; Wirth, Dyann F. ; Legrand, Eric ; Fidock, David A. ; Neafsey, Daniel E. ; Musset, Lise
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-09, Vol.112 (37), p.11672-11677
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Prevalence of arps10, fd, pfmdr-2, pfcrt and pfkelch13 gene mutations in Plasmodium falciparum parasite population in Uganda
Author / Creator:Ocan, Moses ; Ashaba, Fred Katabazi ; Mwesigwa, Savannah ; Edgar, Kigozi ; Kamya, Moses R. ; Nsobya, Sam L.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2022-05, Vol.17 (5), p.e0268095-e0268095
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A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance
Author / Creator:Lakshmanan, Viswanathan ; Bray, Patrick G ; Verdier-Pinard, Dominik ; Johnson, David J ; Horrocks, Paul ; Muhle, Rebecca A ; Alakpa, George E ; Hughes, Ruth H ; Ward, Steve A ; Krogstad, Donald J ; Sidhu, Amar Bir Singh ; Fidock, David A
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2005-07, Vol.24 (13), p.2294-2305
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Molecular survey of pfmdr-1, pfcrt, and pfk13 gene mutations among patients returning from Plasmodium falciparum endemic areas to Turkey
Author / Creator:Avci, Kübra Dilan ; KarakuÅ, Mehmet ; Kart YaÅar, Kadriye
Publisher:England: BioMed Central Ltd
Journal title:Malaria journal, 2024-09, Vol.23 (1), p.286-9, Article 286
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Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT
Author / Creator:Shafik, Sarah Heckmatt ; Richards, Sashika Natasha ; Corry, Ben ; Martin, Rowena Elizabeth
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2022-05, Vol.20 (5), p.e3001616-e3001616
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Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities
Author / Creator:Pulcini, Serena ; Staines, Henry M. ; Lee, Andrew H. ; Shafik, Sarah H. ; Bouyer, Guillaume ; Moore, Catherine M. ; Daley, Daniel A. ; Hoke, Matthew J. ; Altenhofen, Lindsey M. ; Painter, Heather J. ; Mu, Jianbing ; Ferguson, David J. P. ; Llinás, Manuel ; Martin, Rowena E. ; Fidock, David A. ; Cooper, Roland A. ; Krishna, Sanjeev
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2015-09, Vol.5 (1), p.14552-14552, Article 14552
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Surveillance of Plasmodium falciparum pfcrt haplotypes in southwestern Uganda by high‐resolution melt analysis
Author / Creator:Kassaza, Kennedy ; Long, Anna C. ; McDaniels, Jennifer M. ; Andre, Mharlove ; Fredrickson, Wasswa ; Nyehangane, Dan ; Orikiriza, Patrick ; Operario, Darwin J. ; Bazira, Joel ; Mwanga-Amumpaire, Juliet A. ; Moore, Christopher C. ; Guler, Jennifer L. ; Boum, Yap
Publisher:England: BioMed Central Ltd
Journal title:Malaria journal, 2021-02, Vol.20 (1), p.114-114, Article 114
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Directional Selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu Loci of Plasmodium falciparum in Kenyan Children Treated With ACT
Author / Creator:Henriques, Gisela ; Hallett, Rachel L. ; Beshir, Khalid B. ; Gadalla, Nahla B. ; Johnson, Rachel E. ; Burrow, Rebekah ; van Schalkwyk, Donelly A. ; Sawa, Patrick ; Omar, Sabah A. ; Clark, Taane G. ; Bousema, Teun ; Sutherland, Colin J.
Publisher:Oxford: Oxford University Press
Journal title:The Journal of infectious diseases, 2014-12, Vol.210 (12), p.2001-2008
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Polymorphisms in the Pfcrt, Pfmdr1, and Pfk13 genes of Plasmodium falciparum isolates from southern Brazzaville, Republic of Congo
Author / Creator:Baina, Marcel Tapsou ; Djontu, Jean Claude ; Mbama Ntabi, Jacques Dollon ; Mfoutou Mapanguy, Claujens Chastel ; Lissom, Abel ; Vouvoungui, Christevy Jeannhey ; Boumpoutou, Reauchelvy Kamal ; Mouanga, Alain Maxime ; Nguimbi, Etienne ; Ntoumi, Francine
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-11, Vol.14 (1), p.27988-11, Article 27988
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Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages
Author / Creator:Okombo, John ; Mok, Sachel ; Qahash, Tarrick ; Yeo, Tomas ; Bath, Jade ; Orchard, Lindsey M. ; Owens, Edward ; Koo, Imhoi ; Albert, Istvan ; Llinás, Manuel ; Fidock, David A.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2022-10, Vol.18 (10), p.e1010926
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Molecular basis of the functional conflict between chloroquine and peptide transport in the Malaria parasite chloroquine resistance transporter PfCRT
Author / Creator:Tanner, John D. ; Richards, Sashika N. ; Corry, Ben
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-03, Vol.16 (1), p.2987-16, Article 2987
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Retraction Note: Malaria in urban, semi‑urban and rural areas of southern of Gabon: comparison of the Pfmdr 1 and Pfcrt genotypes from symptomatic children
Author / Creator:Maghendji-Nzondo, Sydney ; Kouna, Lady-Charlène ; Mourembou, Gaël ; Boundenga, Larson ; Imboumy-Limoukou, Romeo-Karl ; Matsiegui, Pierre-Blaise ; Manego-Zoleko, Rella ; Mbatchi, Bertrand ; Raoult, Didier ; Toure-Ndouo, Fousseyni ; Lekana-Douki, Jean Bernard
Publisher:England: BioMed Central Ltd
Journal title:Malaria journal, 2025-03, Vol.24 (1), p.93-1, Article 93
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In Vivo Selection of Plasmodium falciparum Parasites Carrying the Chloroquine-Susceptible pfcrt K76 Allele after Treatment with Artemether-Lumefantrine in Africa
Author / Creator:Sisowath, Christin ; Petersen, Ines ; Veiga, M. Isabel ; Mårtensson, Andreas ; Premji, Zul ; Björkman, Anders ; Fidock, David A. ; Gil, José P.
Publisher:Oxford: The University of Chicago Press
Journal title:The Journal of infectious diseases, 2009-03, Vol.199 (5), p.750-757
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Analysis of Plasmodium falciparum Pfcrt and Pfmdr1 genes in parasite isolates from asymptomatic individuals in Southeast Nigeria 11 years after withdrawal of chloroquine
Author / Creator:Ikegbunam, Moses N. ; Nkonganyi, Charles N. ; Thomas, Bolaji N. ; Esimone, Charles O. ; Velavan, Thirumalaisamy P. ; Ojurongbe, Olusola
Publisher:England: BioMed Central Ltd
Journal title:Malaria journal, 2019-10, Vol.18 (1), p.343-7, Article 343
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A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants
Author / Creator:Ferreira, Letícia Tiburcio ; Cassiano, Gustavo Capatti ; Alvarez, Luis Carlos Salazar ; Okombo, John ; Calit, Juliana ; Fontinha, Diana ; Gil-Iturbe, Eva ; Coyle, Rachael ; Andrade, Carolina Horta ; Sunnerhagen, Per ; Bargieri, Daniel Youssef ; Prudêncio, Miguel ; Quick, Matthias ; Cravo, Pedro V. ; Lee, Marcus C. S. ; Fidock, David A. ; Costa, Fabio Trindade Maranhão
Publisher:United States: PLoS
Journal title:PLoS pathogens, 2024-10, Vol.20 (10), p.e1012627
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PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport
Author / Creator:Gomez, Guillermo M. ; D’Arrigo, Giulia ; Sanchez, Cecilia P. ; Berger, Fiona ; Wade, Rebecca C. ; Lanzer, Michael
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2023-06, Vol.19 (6), p.e1011436-e1011436
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Showing 1 to 20 of 776 results

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Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

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Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

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Plasmodium falciparum resistance to piperaquine driven by PfCRT

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Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum

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Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt

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Prevalence of arps10, fd, pfmdr-2, pfcrt and pfkelch13 gene mutations in Plasmodium falciparum parasite population in Uganda

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A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance

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Molecular survey of pfmdr-1, pfcrt, and pfk13 gene mutations among patients returning from Plasmodium falciparum endemic areas to Turkey

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Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT

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Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities

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Surveillance of Plasmodium falciparum pfcrt haplotypes in southwestern Uganda by high‐resolution melt analysis

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Directional Selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu Loci of Plasmodium falciparum in Kenyan Children Treated With ACT

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Polymorphisms in the Pfcrt, Pfmdr1, and Pfk13 genes of Plasmodium falciparum isolates from southern Brazzaville, Republic of Congo

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Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

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Molecular basis of the functional conflict between chloroquine and peptide transport in the Malaria parasite chloroquine resistance transporter PfCRT

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Retraction Note: Malaria in urban, semi‑urban and rural areas of southern of Gabon: comparison of the Pfmdr 1 and Pfcrt genotypes from symptomatic children

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In Vivo Selection of Plasmodium falciparum Parasites Carrying the Chloroquine-Susceptible pfcrt K76 Allele after Treatment with Artemether-Lumefantrine in Africa

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Analysis of Plasmodium falciparum Pfcrt and Pfmdr1 genes in parasite isolates from asymptomatic individuals in Southeast Nigeria 11 years after withdrawal of chloroquine

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A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants

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PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport

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