mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress
mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress
About this item
Full title
Author / Creator
Grahammer, Florian , Haenisch, Nora , Steinhardt, Frederic , Sandner, Lukas , Sander, Lukas , Roerden, Malte , Arnold, Frederic , Cordts, Tomke , Wanner, Nicola , Reichardt, Wilfried , Kerjaschki, Dontscho , Ruegg, Markus A , Hall, Michael N , Moulin, Pierre , Busch, Hauke , Boerries, Melanie , Walz, Gerd , Artunc, Ferruh and Huber, Tobias B
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell metabolism and autophagy. Despite widespread clinical use of mTORC1 inhibitors, the role of mTORC1 in renal tubular function and kidney homeostasis remains elusive. By using constitutive and inducible deletion of conditional Raptor alleles in renal tubular epithelial cells,...
Alternative Titles
Full title
mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress
Authors, Artists and Contributors
Author / Creator
Haenisch, Nora
Steinhardt, Frederic
Sandner, Lukas
Sander, Lukas
Roerden, Malte
Arnold, Frederic
Cordts, Tomke
Wanner, Nicola
Reichardt, Wilfried
Kerjaschki, Dontscho
Ruegg, Markus A
Hall, Michael N
Moulin, Pierre
Busch, Hauke
Boerries, Melanie
Walz, Gerd
Artunc, Ferruh
Huber, Tobias B
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1402352111
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1402352111
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1402352111
