Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
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Author / Creator
Wettstein, Lukas , Weil, Tatjana , Conzelmann, Carina , Müller, Janis A. , Groß, Rüdiger , Hirschenberger, Maximilian , Seidel, Alina , Klute, Susanne , Zech, Fabian , Prelli Bozzo, Caterina , Preising, Nico , Fois, Giorgio , Lochbaum, Robin , Knaff, Philip Maximilian , Mailänder, Volker , Ständker, Ludger , Thal, Dietmar Rudolf , Schumann, Christian , Stenger, Steffen , Kleger, Alexander , Lochnit, Günter , Mayer, Benjamin , Ruiz-Blanco, Yasser B. , Hoffmann, Markus , Sparrer, Konstantin M. J. , Pöhlmann, Stefan , Sanchez-Garcia, Elsa , Kirchhoff, Frank , Frick, Manfred and Münch, Jan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
SARS-CoV-2 is a respiratory pathogen and primarily infects the airway epithelium. As our knowledge about innate immune factors of the respiratory tract against SARS-CoV-2 is limited, we generated and screened a peptide/protein library derived from bronchoalveolar lavage for inhibitors of SARS-CoV-2 spike-driven entry. Analysis of antiviral fraction...
Alternative Titles
Full title
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
Authors, Artists and Contributors
Author / Creator
Weil, Tatjana
Conzelmann, Carina
Müller, Janis A.
Groß, Rüdiger
Hirschenberger, Maximilian
Seidel, Alina
Klute, Susanne
Zech, Fabian
Prelli Bozzo, Caterina
Preising, Nico
Fois, Giorgio
Lochbaum, Robin
Knaff, Philip Maximilian
Mailänder, Volker
Ständker, Ludger
Thal, Dietmar Rudolf
Schumann, Christian
Stenger, Steffen
Kleger, Alexander
Lochnit, Günter
Mayer, Benjamin
Ruiz-Blanco, Yasser B.
Hoffmann, Markus
Sparrer, Konstantin M. J.
Pöhlmann, Stefan
Sanchez-Garcia, Elsa
Kirchhoff, Frank
Frick, Manfred
Münch, Jan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_056726122e3545e6b5177624a1dc537a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_056726122e3545e6b5177624a1dc537a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21972-0
