Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resis...
Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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In amyotrophic lateral sclerosis (ALS) spinal motor neurons (SpMN) progressively degenerate while a subset of cranial motor neurons (CrMN) are spared until late stages of the disease. Using a rapid and efficient protocol to differentiate mouse embryonic stem cells (ESC) to SpMNs and CrMNs, we now report that ESC-derived CrMNs accumulate less human...
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Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons
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TN_cdi_doaj_primary_oai_doaj_org_article_0f4bd1185c1e462d992daccca11bd0d2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0f4bd1185c1e462d992daccca11bd0d2
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2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.44423
