Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertil...
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility
About this item
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Author / Creator
Zhang, Dao-Lai , Sun, Yu-Jing , Ma, Ming-Liang , Wang, Yi-Jing , Lin, Hui , Li, Rui-Rui , Liang, Zong-Lai , Gao, Yuan , Yang, Zhao , He, Dong-Fang , Lin, Amy , Mo, Hui , Lu, Yu-Jing , Li, Meng-Jing , Kong, Wei , Chung, Ka Young , Yi, Fan , Li, Jian-Yuan , Qin, Ying-Ying , Li, Jingxin , Thomsen, Alex R B , Kahsai, Alem W , Chen, Zi-Jiang , Xu, Zhi-Gang , Liu, Mingyao , Li, Dali , Yu, Xiao and Sun, Jin-Peng
Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
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Publication information
Publisher
England: eLife Sciences Publications Ltd
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More information
Scope and Contents
Contents
Luminal fluid reabsorption plays a fundamental role in male fertility. We demonstrated that the ubiquitous GPCR signaling proteins Gq and β-arrestin-1 are essential for fluid reabsorption because they mediate coupling between an orphan receptor ADGRG2 (GPR64) and the ion channel CFTR. A reduction in protein level or deficiency of ADGRG2, Gq or β-ar...
Alternative Titles
Full title
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility
Authors, Artists and Contributors
Author / Creator
Sun, Yu-Jing
Ma, Ming-Liang
Wang, Yi-Jing
Lin, Hui
Li, Rui-Rui
Liang, Zong-Lai
Gao, Yuan
Yang, Zhao
He, Dong-Fang
Lin, Amy
Mo, Hui
Lu, Yu-Jing
Li, Meng-Jing
Kong, Wei
Chung, Ka Young
Yi, Fan
Li, Jian-Yuan
Qin, Ying-Ying
Li, Jingxin
Thomsen, Alex R B
Kahsai, Alem W
Chen, Zi-Jiang
Xu, Zhi-Gang
Liu, Mingyao
Li, Dali
Yu, Xiao
Sun, Jin-Peng
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_160cb752179d4fe99a359e4cf629a263
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_160cb752179d4fe99a359e4cf629a263
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.33432
