Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-assoc...
Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8 + T cell exclusion
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Author / Creator
Fang, Wenli , Zhou, Ting , Shi, He , Yao, Mengli , Zhang, Dian , Qian, Husun , Zeng, Qian , Wang, Yange , Jin, Fangfang , Chai, Chengsen and Chen, Tingmei
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the effect of PGRN on breast cancer tumor immunity and its possible molecular mechanism.
The changes of macrophage phenotypes after PGRN treatment were detected by western blot, qu...
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Full title
Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8 + T cell exclusion
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1f3b7095807644b78563ed3fafea797a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1f3b7095807644b78563ed3fafea797a
Other Identifiers
ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-020-01786-6
