VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Hunti...
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Mutant Huntingtin (mtHtt) causes neurodegeneration in Huntington’s disease (HD) by evoking defects in the mitochondria, but the underlying mechanisms remains elusive. Our proteomic analysis identifies valosin-containing protein (VCP) as an mtHtt-binding protein on the mitochondria. Here we show that VCP is selectively translocated to the mitochondr...
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VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
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TN_cdi_doaj_primary_oai_doaj_org_article_1f55ff619f9e46718fcb0202f07879be
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1f55ff619f9e46718fcb0202f07879be
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12646
