A conserved molecular switch in Class F receptors regulates receptor activation and pathway selectio...
A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection
About this item
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Author / Creator
Wright, Shane C. , Kozielewicz, Paweł , Kowalski-Jahn, Maria , Petersen, Julian , Bowin, Carl-Fredrik , Slodkowicz, Greg , Marti-Solano, Maria , Rodríguez, David , Hot, Belma , Okashah, Najeah , Strakova, Katerina , Valnohova, Jana , Babu, M. Madan , Lambert, Nevin A. , Carlsson, Jens and Schulte, Gunnar
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Class F receptors are considered valuable therapeutic targets due to their role in human disease, but structural changes accompanying receptor activation remain unexplored. Employing population and cancer genomics data, structural analyses, molecular dynamics simulations, resonance energy transfer-based approaches and mutagenesis, we identify a con...
Alternative Titles
Full title
A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_25eb2e5a80d940629421bb3eaf96fb01
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_25eb2e5a80d940629421bb3eaf96fb01
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-08630-2
