Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure
Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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In autophagy, Atg proteins organize the pre-autophagosomal structure (PAS) to initiate autophagosome formation. Previous studies in yeast revealed that the autophagy-related E3 complex Atg12-Atg5-Atg16 is recruited to the PAS via Atg16 interaction with Atg21, which binds phosphatidylinositol 3-phosphate (PI3P) produced at the PAS, to stimulate conj...
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Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure
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TN_cdi_doaj_primary_oai_doaj_org_article_359887c7927e48129305c8be1c0d9be5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_359887c7927e48129305c8be1c0d9be5
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.43088
