Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgen...
Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Pathological tau inclusions are neuropathologic hallmarks of many neurodegenerative diseases. We generated and characterized a transgenic mouse model expressing pathogenic human tau with S320F and P301S aggregating mutations (SPAM) at transgene levels below endogenous mouse tau protein levels. This mouse model develops a predictable temporal progre...
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Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice
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TN_cdi_doaj_primary_oai_doaj_org_article_3a9421f02cdb4806af6f325540e97ae6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3a9421f02cdb4806af6f325540e97ae6
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-022-03373-1
