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EccDNA atlas in male mice reveals features protecting genes against transcription-induced eccDNA for...

EccDNA atlas in male mice reveals features protecting genes against transcription-induced eccDNA for...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3db2a1f82749430dabdcbff297918395

EccDNA atlas in male mice reveals features protecting genes against transcription-induced eccDNA formation

About this item

Full title

EccDNA atlas in male mice reveals features protecting genes against transcription-induced eccDNA formation

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2025-02, Vol.16 (1), p.1872-12, Article 1872

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

eccDNA is a driver of many cancers and a potential intermediate in other age-related disorders. However, little is known about the mechanisms underlying eccDNA formation in healthy tissue and how aging affects these processes. Here, we present an atlas of eccDNA across seven tissues of male mice spanning four ages. EccDNA correlates with open chrom...

Alternative Titles

Full title

EccDNA atlas in male mice reveals features protecting genes against transcription-induced eccDNA formation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_3db2a1f82749430dabdcbff297918395

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3db2a1f82749430dabdcbff297918395

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-025-57042-y

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