Negative selection in tumor genome evolution acts on essential cellular functions and the immunopept...
Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Natural selection shapes cancer genomes. Previous studies used signatures of positive selection to identify genes driving malignant transformation. However, the contribution of negative selection against somatic mutations that affect essential tumor functions or specific domains remains a controversial topic.
Here, we analyze 7546 individual exo...
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Full title
Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome
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TN_cdi_doaj_primary_oai_doaj_org_article_3f022dcda0ff4afbb1406672a2971dd5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3f022dcda0ff4afbb1406672a2971dd5
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ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-018-1434-0
