Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer...
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
About this item
Full title
Author / Creator
Tajan, Mylène , Hennequart, Marc , Cheung, Eric C. , Zani, Fabio , Hock, Andreas K. , Legrave, Nathalie , Maddocks, Oliver D. K. , Ridgway, Rachel A. , Athineos, Dimitris , Suárez-Bonnet, Alejandro , Ludwig, Robert L. , Novellasdemunt, Laura , Angelis, Nikolaos , Li, Vivian S. W. , Vlachogiannis, Georgios , Valeri, Nicola , Mainolfi, Nello , Suri, Vipin , Friedman, Adam , Manfredi, Mark , Blyth, Karen , Sansom, Owen J. and Vousden, Karen H.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in mice. However, numerous mechanisms promote resistance to this therapeutic approach, including enhanced expression of the de novo serine synthesis pathway (SSP) enzymes or activation of oncoge...
Alternative Titles
Full title
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
Authors, Artists and Contributors
Author / Creator
Hennequart, Marc
Cheung, Eric C.
Zani, Fabio
Hock, Andreas K.
Legrave, Nathalie
Maddocks, Oliver D. K.
Ridgway, Rachel A.
Athineos, Dimitris
Suárez-Bonnet, Alejandro
Ludwig, Robert L.
Novellasdemunt, Laura
Angelis, Nikolaos
Li, Vivian S. W.
Vlachogiannis, Georgios
Valeri, Nicola
Mainolfi, Nello
Suri, Vipin
Friedman, Adam
Manfredi, Mark
Blyth, Karen
Sansom, Owen J.
Vousden, Karen H.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4b3a136e97e9418588502ed7dece3071
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4b3a136e97e9418588502ed7dece3071
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-20223-y
