Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation...
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway
About this item
Full title
Author / Creator
Fujino, Takeshi , Goyama, Susumu , Sugiura, Yuki , Inoue, Daichi , Asada, Shuhei , Yamasaki, Satoshi , Matsumoto, Akiko , Yamaguchi, Kiyoshi , Isobe, Yumiko , Tsuchiya, Akiho , Shikata, Shiori , Sato, Naru , Morinaga, Hironobu , Fukuyama, Tomofusa , Tanaka, Yosuke , Fukushima, Tsuyoshi , Takeda, Reina , Yamamoto, Keita , Honda, Hiroaki , Nishimura, Emi K. , Furukawa, Yoichi , Shibata, Tatsuhiro , Abdel-Wahab, Omar , Suematsu, Makoto and Kitamura, Toshio
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Somatic mutations of
ASXL1
are frequently detected in age-related clonal hematopoiesis (CH). However, how
ASXL1
mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examined the influence of ASXL1-MT on physiological aging in hematopoietic stem cells (HSCs)....
Alternative Titles
Full title
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway
Authors, Artists and Contributors
Author / Creator
Goyama, Susumu
Sugiura, Yuki
Inoue, Daichi
Asada, Shuhei
Yamasaki, Satoshi
Matsumoto, Akiko
Yamaguchi, Kiyoshi
Isobe, Yumiko
Tsuchiya, Akiho
Shikata, Shiori
Sato, Naru
Morinaga, Hironobu
Fukuyama, Tomofusa
Tanaka, Yosuke
Fukushima, Tsuyoshi
Takeda, Reina
Yamamoto, Keita
Honda, Hiroaki
Nishimura, Emi K.
Furukawa, Yoichi
Shibata, Tatsuhiro
Abdel-Wahab, Omar
Suematsu, Makoto
Kitamura, Toshio
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5a4339b6caee4c1d9bbb984e54dddbf0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5a4339b6caee4c1d9bbb984e54dddbf0
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22053-y
