Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for...
Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2
About this item
Full title
Author / Creator
Malik, Vikas , Glaser, Laura V. , Zimmer, Dennis , Velychko, Sergiy , Weng, Mingxi , Holzner, Markus , Arend, Marius , Chen, Yanpu , Srivastava, Yogesh , Veerapandian, Veeramohan , Shah, Zahir , Esteban, Miguel A. , Wang, Huating , Chen, Jiekai , Schöler, Hans R. , Hutchins, Andrew P. , Meijsing, Sebastiaan H. , Pott, Sebastian and Jauch, Ralf
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Oct4, along with Sox2 and Klf4 (SK), can induce pluripotency but structurally similar factors like Oct6 cannot. To decode why Oct4 has this unique ability, we compare Oct4-binding, accessibility patterns and transcriptional waves with Oct6 and an Oct4 mutant defective in the dimerization with Sox2 (Oct4
defSox2
). We find that initial silenci...
Alternative Titles
Full title
Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2
Authors, Artists and Contributors
Author / Creator
Glaser, Laura V.
Zimmer, Dennis
Velychko, Sergiy
Weng, Mingxi
Holzner, Markus
Arend, Marius
Chen, Yanpu
Srivastava, Yogesh
Veerapandian, Veeramohan
Shah, Zahir
Esteban, Miguel A.
Wang, Huating
Chen, Jiekai
Schöler, Hans R.
Hutchins, Andrew P.
Meijsing, Sebastiaan H.
Pott, Sebastian
Jauch, Ralf
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_5d839fd6128d4d118a7cbf72a69b4f17
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_5d839fd6128d4d118a7cbf72a69b4f17
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11054-7
