Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearan...
Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However, the mechanism by which this occurs has not yet been uncovered. Here, we investigated the effect of CF on the expression of two bona fide regulators of circulating low-density lipoprotein cholesterol (LDLc) levels; the proprotein convertase subtilisin/kexin type...
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Full title
Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance
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TN_cdi_doaj_primary_oai_doaj_org_article_6733f73670aa4d5a807867eed2c293ea
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6733f73670aa4d5a807867eed2c293ea
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-28240-9
