A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models
A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models
About this item
Full title
Author / Creator
Wirth, Fabian , Heitz, Fabrice D. , Seeger, Christine , Combaluzier, Ioana , Breu, Karin , Denroche, Heather C. , Thevenet, Julien , Osto, Melania , Arosio, Paolo , Kerr-Conte, Julie , Verchere, C. Bruce , Pattou, François , Lutz, Thomas A. , Donath, Marc Y. , Hock, Christoph , Nitsch, Roger M. and Grimm, Jan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose. Beta cell dysfunction and loss is associated with an accumulation of aggregated forms of islet amyloid polypeptide (IAPP) consisting of soluble prefibrillar IAPP oligomers as well as insolu...
Alternative Titles
Full title
A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_68eb80d31bdf42208e648a12724a93bf
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_68eb80d31bdf42208e648a12724a93bf
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41986-0
