NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD + depletion
NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD + depletion
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England: eLife Sciences Publications Ltd
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Language
English
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England: eLife Sciences Publications Ltd
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Contents
Overexpression of the NAD
biosynthetic enzyme NMNAT1 leads to preservation of injured axons. While increased NAD
or decreased NMN levels are thought to be critical to this process, the mechanism(s) of this axon protection remain obscure. Using steady-state and flux analysis of NAD
metabolites in healthy and injured mouse dorsal root gangli...
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Full title
NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD + depletion
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TN_cdi_doaj_primary_oai_doaj_org_article_6f1e6c76a8464e2dbc43936818a6d912
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6f1e6c76a8464e2dbc43936818a6d912
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.19749
