RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a nove...
RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway
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Author / Creator
Chattopadhyay, Shiladitya , Garcia-Martinez, Jose , Haimovich, Gal , Fischer, Jonathan , Khwaja, Aya , Barkai, Oren , Chuartzman, Silvia Gabriela , Schuldiner, Maya , Elran, Ron , Rosenberg, Miriam I. , Urim, Shira , Deshmukh, Shubham , Bohnsack, Katherine E. , Bohnsack, Markus T. , Perez-Ortin, Jose E. and Choder, Mordechai
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
mRNA level is controlled by factors that mediate both mRNA synthesis and decay, including the 5’ to 3’ exonuclease Xrn1. Here we show that nucleocytoplasmic shuttling of several yeast mRNA decay factors plays a key role in determining both mRNA synthesis and decay. Shuttling is regulated by RNA-controlled binding of the karyopherin Kap120 to two nu...
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Full title
RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway
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TN_cdi_doaj_primary_oai_doaj_org_article_76e659328ff74fa9b932927ad681792b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_76e659328ff74fa9b932927ad681792b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34417-z
