Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lympho...
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia
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Author / Creator
Isobe, Tomoya , Takagi, Masatoshi , Sato-Otsubo, Aiko , Nishimura, Akira , Nagae, Genta , Yamagishi, Chika , Tamura, Moe , Tanaka, Yosuke , Asada, Shuhei , Takeda, Reina , Tsuchiya, Akiho , Wang, Xiaonan , Yoshida, Kenichi , Nannya, Yasuhito , Ueno, Hiroo , Akazawa, Ryo , Kato, Itaru , Mikami, Takashi , Watanabe, Kentaro , Sekiguchi, Masahiro , Seki, Masafumi , Kimura, Shunsuke , Hiwatari, Mitsuteru , Kato, Motohiro , Fukuda, Shiro , Tatsuno, Kenji , Tsutsumi, Shuichi , Kanai, Akinori , Inaba, Toshiya , Shiozawa, Yusuke , Shiraishi, Yuichi , Chiba, Kenichi , Tanaka, Hiroko , Kotecha, Rishi S. , Cruickshank, Mark N. , Ishikawa, Fumihiko , Morio, Tomohiro , Eguchi, Mariko , Deguchi, Takao , Kiyokawa, Nobutaka , Arakawa, Yuki , Koh, Katsuyoshi , Aoki, Yuki , Ishihara, Takashi , Tomizawa, Daisuke , Miyamura, Takako , Ishii, Eiichi , Mizutani, Shuki , Wilson, Nicola K. , Göttgens, Berthold , Miyano, Satoru , Kitamura, Toshio , Goyama, Susumu , Yokoyama, Akihiko , Aburatani, Hiroyuki , Ogawa, Seishi and Takita, Junko
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
KMT2A
-rearranged infant acute lymphoblastic leukemia (ALL) represents the most refractory type of childhood leukemia. To uncover the molecular heterogeneity of this disease, we perform RNA sequencing, methylation array analysis, whole exome and targeted deep sequencing on 84 infants with
KMT2A
-rearranged leukemia. Our multi-omics cluster...
Alternative Titles
Full title
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia
Authors, Artists and Contributors
Author / Creator
Takagi, Masatoshi
Sato-Otsubo, Aiko
Nishimura, Akira
Nagae, Genta
Yamagishi, Chika
Tamura, Moe
Tanaka, Yosuke
Asada, Shuhei
Takeda, Reina
Tsuchiya, Akiho
Wang, Xiaonan
Yoshida, Kenichi
Nannya, Yasuhito
Ueno, Hiroo
Akazawa, Ryo
Kato, Itaru
Mikami, Takashi
Watanabe, Kentaro
Sekiguchi, Masahiro
Seki, Masafumi
Kimura, Shunsuke
Hiwatari, Mitsuteru
Kato, Motohiro
Fukuda, Shiro
Tatsuno, Kenji
Tsutsumi, Shuichi
Kanai, Akinori
Inaba, Toshiya
Shiozawa, Yusuke
Shiraishi, Yuichi
Chiba, Kenichi
Tanaka, Hiroko
Kotecha, Rishi S.
Cruickshank, Mark N.
Ishikawa, Fumihiko
Morio, Tomohiro
Eguchi, Mariko
Deguchi, Takao
Kiyokawa, Nobutaka
Arakawa, Yuki
Koh, Katsuyoshi
Aoki, Yuki
Ishihara, Takashi
Tomizawa, Daisuke
Miyamura, Takako
Ishii, Eiichi
Mizutani, Shuki
Wilson, Nicola K.
Göttgens, Berthold
Miyano, Satoru
Kitamura, Toshio
Goyama, Susumu
Yokoyama, Akihiko
Aburatani, Hiroyuki
Ogawa, Seishi
Takita, Junko
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_7fee3de7cd6b4b10b237a1df0b62b1d6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7fee3de7cd6b4b10b237a1df0b62b1d6
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32266-4
