Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localiz...
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization
About this item
Full title
Author / Creator
Casci, Ian , Krishnamurthy, Karthik , Kour, Sukhleen , Tripathy, Vadreenath , Ramesh, Nandini , Anderson, Eric N. , Marrone, Lara , Grant, Rogan A. , Oliver, Stacie , Gochenaur, Lauren , Patel, Krishani , Sterneckert, Jared , Gleixner, Amanda M. , Donnelly, Christopher J. , Ruepp, Marc-David , Sini, Antonella M. , Zuccaro, Emanuela , Pennuto, Maria , Pasinelli, Piera and Pandey, Udai Bhan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mutations in
fused in sarcoma (FUS)
lead to amyotrophic lateral sclerosis (ALS) with varying ages of onset, progression and severity. This suggests that unknown genetic factors contribute to disease pathogenesis. Here we show the identification of muscleblind as a novel modifier of FUS-mediated neurodegeneration in vivo. Muscleblind regulates...
Alternative Titles
Full title
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization
Authors, Artists and Contributors
Author / Creator
Krishnamurthy, Karthik
Kour, Sukhleen
Tripathy, Vadreenath
Ramesh, Nandini
Anderson, Eric N.
Marrone, Lara
Grant, Rogan A.
Oliver, Stacie
Gochenaur, Lauren
Patel, Krishani
Sterneckert, Jared
Gleixner, Amanda M.
Donnelly, Christopher J.
Ruepp, Marc-David
Sini, Antonella M.
Zuccaro, Emanuela
Pennuto, Maria
Pasinelli, Piera
Pandey, Udai Bhan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_808f528e987e4f6fbf0a7d25207ff6ed
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_808f528e987e4f6fbf0a7d25207ff6ed
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13383-z
