Physiologically based pharmacokinetic modeling of tacrolimus for food–drug and CYP3A drug–drug–gene...
Physiologically based pharmacokinetic modeling of tacrolimus for food–drug and CYP3A drug–drug–gene interaction predictions
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United States: John Wiley & Sons, Inc
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Language
English
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Publisher
United States: John Wiley & Sons, Inc
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The immunosuppressant and narrow therapeutic index drug tacrolimus is metabolized mainly via cytochrome P450 (CYP) 3A4 and CYP3A5. For its pharmacokinetics (PK), high inter‐ and intra‐individual variability can be observed. Underlying causes include the effect of food intake on tacrolimus absorption as well as genetic polymorphism in the CYP3A5 gen...
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Full title
Physiologically based pharmacokinetic modeling of tacrolimus for food–drug and CYP3A drug–drug–gene interaction predictions
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TN_cdi_doaj_primary_oai_doaj_org_article_8f442549019b44338f8e3c2b8a8de9ff
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8f442549019b44338f8e3c2b8a8de9ff
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ISSN
2163-8306
E-ISSN
2163-8306
DOI
10.1002/psp4.12946
