Extensive co-binding and rapid redistribution of NANOG and GATA6 during emergence of divergent linea...
Extensive co-binding and rapid redistribution of NANOG and GATA6 during emergence of divergent lineages
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Fate-determining transcription factors (TFs) can promote lineage-restricted transcriptional programs from common progenitor states. The inner cell mass (ICM) of mouse blastocysts co-expresses the TFs NANOG and GATA6, which drive the bifurcation of the ICM into either the epiblast (Epi) or the primitive endoderm (PrE), respectively. Here, we induce...
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Extensive co-binding and rapid redistribution of NANOG and GATA6 during emergence of divergent lineages
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TN_cdi_doaj_primary_oai_doaj_org_article_962d0a44d17944c7b63623a06c0ef327
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_962d0a44d17944c7b63623a06c0ef327
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-31938-5
