Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Sebaceous carcinomas (SeC) are cutaneous malignancies that, in rare cases, metastasize and prove fatal. Here we report whole-exome sequencing on 32 SeC, revealing distinct mutational classes that explain both cancer ontogeny and clinical course. A UV-damage signature predominates in 10/32 samples, while nine show microsatellite instability (MSI) pr...
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Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
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TN_cdi_doaj_primary_oai_doaj_org_article_a7a23b1126f944b2aad81a9029010a17
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a7a23b1126f944b2aad81a9029010a17
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04008-y
