Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
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Author / Creator
Ju, Young Seok , Alexandrov, Ludmil B , Gerstung, Moritz , Martincorena, Inigo , Nik-Zainal, Serena , Ramakrishna, Manasa , Davies, Helen R , Papaemmanuil, Elli , Gundem, Gunes , Shlien, Adam , Bolli, Niccolo , Behjati, Sam , Tarpey, Patrick S , Nangalia, Jyoti , Massie, Charles E , Butler, Adam P , Teague, Jon W , Vassiliou, George S , Green, Anthony R , Du, Ming-Qing , Unnikrishnan, Ashwin , Pimanda, John E , Teh, Bin Tean , Munshi, Nikhil , Greaves, Mel , Vyas, Paresh , El-Naggar, Adel K , Santarius, Tom , Collins, V Peter , Grundy, Richard , Taylor, Jack A , Hayes, D Neil , Malkin, David , Foster, Christopher S , Warren, Anne Y , Whitaker, Hayley C , Brewer, Daniel , Eeles, Rosalind , Cooper, Colin , Neal, David , Visakorpi, Tapio , Isaacs, William B , Bova, G Steven , Flanagan, Adrienne M , Futreal, P Andrew , Lynch, Andy G , Chinnery, Patrick F , McDermott, Ultan , Stratton, Michael R , Campbell, Peter J , ICGC Breast Cancer Group , ICGC Chronic Myeloid Disorders Group and ICGC Prostate Cancer Group
Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are unclear. In this study, we analyzed somatic alterations in mtDNA from 1675 tumors. We identified 1907...
Alternative Titles
Full title
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
Authors, Artists and Contributors
Author / Creator
Alexandrov, Ludmil B
Gerstung, Moritz
Martincorena, Inigo
Nik-Zainal, Serena
Ramakrishna, Manasa
Davies, Helen R
Papaemmanuil, Elli
Gundem, Gunes
Shlien, Adam
Bolli, Niccolo
Behjati, Sam
Tarpey, Patrick S
Nangalia, Jyoti
Massie, Charles E
Butler, Adam P
Teague, Jon W
Vassiliou, George S
Green, Anthony R
Du, Ming-Qing
Unnikrishnan, Ashwin
Pimanda, John E
Teh, Bin Tean
Munshi, Nikhil
Greaves, Mel
Vyas, Paresh
El-Naggar, Adel K
Santarius, Tom
Collins, V Peter
Grundy, Richard
Taylor, Jack A
Hayes, D Neil
Malkin, David
Foster, Christopher S
Warren, Anne Y
Whitaker, Hayley C
Brewer, Daniel
Eeles, Rosalind
Cooper, Colin
Neal, David
Visakorpi, Tapio
Isaacs, William B
Bova, G Steven
Flanagan, Adrienne M
Futreal, P Andrew
Lynch, Andy G
Chinnery, Patrick F
McDermott, Ultan
Stratton, Michael R
Campbell, Peter J
ICGC Breast Cancer Group
ICGC Chronic Myeloid Disorders Group
ICGC Prostate Cancer Group
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_a97bb2e0fa0f4eb19b17cd3f405b0385
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a97bb2e0fa0f4eb19b17cd3f405b0385
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.02935
