Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodys...
Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
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Author / Creator
Vu, Therese , Straube, Jasmin , Porter, Amy H. , Bywater, Megan , Song, Axia , Ling, Victoria , Cooper, Leanne , Pali, Gabor , Bruedigam, Claudia , Jacquelin, Sebastien , Green, Joanne , Magor, Graham , Perkins, Andrew , Chalk, Alistair M. , Walkley, Carl R. , Heidel, Florian H. , Mukhopadhyay, Pamela , Cloonan, Nicole , Gröschel, Stefan , Mallm, Jan-Philipp , Fröhling, Stefan , Scholl, Claudia and Lane, Steven W.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during normal blood formation. Retroviral overexpression of Cdx2 induces AML in mice, however the developmental stage at which CDX2 exerts its effect is unknown. We developed a conditionally inducible Cdx2 mouse model to determine the effects of in vivo, in...
Alternative Titles
Full title
Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
Authors, Artists and Contributors
Author / Creator
Straube, Jasmin
Porter, Amy H.
Bywater, Megan
Song, Axia
Ling, Victoria
Cooper, Leanne
Pali, Gabor
Bruedigam, Claudia
Jacquelin, Sebastien
Green, Joanne
Magor, Graham
Perkins, Andrew
Chalk, Alistair M.
Walkley, Carl R.
Heidel, Florian H.
Mukhopadhyay, Pamela
Cloonan, Nicole
Gröschel, Stefan
Mallm, Jan-Philipp
Fröhling, Stefan
Scholl, Claudia
Lane, Steven W.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_bceafc18d13641ee9c5212ab1db8af73
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_bceafc18d13641ee9c5212ab1db8af73
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16840-2
