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Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scan...

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scan...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_be4e9943c217458b99039b79fd1789b0

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning

About this item

Full title

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2024-05, Vol.15 (1), p.4056-12, Article 4056

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane fusion during virus entry and is part of a broadly neutralizing epitope. However, sequence determinants at the fusion peptide and its adjacent regions for pathogenicity and antigenicity remain elusive. In this study, we perform a series of deep mutational scanning...

Alternative Titles

Full title

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_be4e9943c217458b99039b79fd1789b0

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_be4e9943c217458b99039b79fd1789b0

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-024-48104-8

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