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ArticlesPeer ReviewedFull Text
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?
Author / Creator:Wong, Lok-Yin Roy ; Perlman, Stanley
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Immunology, 2022-01, Vol.22 (1), p.47-56
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Author Correction: Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?
Author / Creator:Wong, Lok-Yin Roy ; Perlman, Stanley
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Immunology, 2022-03, Vol.22 (3), p.200-200
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COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice
Author / Creator:Zheng, Jian ; Wong, Lok-Yin Roy ; Li, Kun ; Verma, Abhishek Kumar ; Ortiz, Miguel E. ; Wohlford-Lenane, Christine ; Leidinger, Mariah R. ; Knudson, C. Michael ; Meyerholz, David K. ; McCray, Paul B. ; Perlman, Stanley
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-01, Vol.589 (7843), p.603-607
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SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
Author / Creator:Halfmann, Peter J. ; Iida, Shun ; Iwatsuki-Horimoto, Kiyoko ; Maemura, Tadashi ; Kiso, Maki ; Scheaffer, Suzanne M. ; Darling, Tamarand L. ; Joshi, Astha ; Loeber, Samantha ; Singh, Gagandeep ; Foster, Stephanie L. ; Ying, Baoling ; Case, James Brett ; Chong, Zhenlu ; Whitener, Bradley ; Moliva, Juan ; Floyd, Katharine ; Ujie, Michiko ; Nakajima, Noriko ; Ito, Mutsumi ; Wright, Ryan ; Uraki, Ryuta ; Warang, Prajakta ; Gagne, Matthew ; Li, Rong ; Sakai-Tagawa, Yuko ; Liu, Yanan ; Larson, Deanna ; Osorio, Jorge E. ; Hernandez-Ortiz, Juan P. ; Henry, Amy R. ; Ciuoderis, Karl ; Florek, Kelsey R. ; Patel, Mit ; Odle, Abby ; Wong, Lok-Yin Roy ; Bateman, Allen C. ; Wang, Zhongde ; Edara, Venkata-Viswanadh ; Franks, John ; Jeevan, Trushar ; Fabrizio, Thomas ; DeBeauchamp, Jennifer ; Kercher, Lisa ; Seiler, Patrick ; Gonzalez-Reiche, Ana Silvia ; Sordillo, Emilia Mia ; Chang, Lauren A. ; van Bakel, Harm ; Simon, Viviana ; Douek, Daniel C. ; Sullivan, Nancy J. ; Thackray, Larissa B. ; Ueki, Hiroshi ; Yamayoshi, Seiya ; Imai, Masaki ; Perlman, Stanley ; Webby, Richard J. ; Seder, Robert A. ; Suthar, Mehul S. ; García-Sastre, Adolfo ; Schotsaert, Michael ; Suzuki, Tadaki ; Boon, Adrianus C. M. ; Diamond, Michael S. ; Kawaoka, Yoshihiro
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2022-03, Vol.603 (7902), p.687-692
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ArticlesPeer ReviewedFull Text
Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D
Author / Creator:Zheng, Jian ; Meyerholz, David ; Wong, Lok-Yin Roy ; Gelb, Michael ; Murakami, Makoto ; Perlman, Stanley
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2021-06, Vol.131 (11), p.1-14
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ArticlesPeer ReviewedFull Text
Omicron subvariant BA.5 efficiently infects lung cells
Author / Creator:Hoffmann, Markus ; Wong, Lok-Yin Roy ; Arora, Prerna ; Zhang, Lu ; Rocha, Cheila ; Odle, Abby ; Nehlmeier, Inga ; Kempf, Amy ; Richter, Anja ; Halwe, Nico Joel ; Schön, Jacob ; Ulrich, Lorenz ; Hoffmann, Donata ; Beer, Martin ; Drosten, Christian ; Perlman, Stanley ; Pöhlmann, Stefan
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-06, Vol.14 (1), p.3500-11, Article 3500
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Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning
Author / Creator:Lei, Ruipeng ; Qing, Enya ; Odle, Abby ; Yuan, Meng ; Gunawardene, Chaminda D. ; Tan, Timothy J. C. ; So, Natalie ; Ouyang, Wenhao O. ; Wilson, Ian A. ; Gallagher, Tom ; Perlman, Stanley ; Wu, Nicholas C. ; Wong, Lok-Yin Roy
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-05, Vol.15 (1), p.4056-12, Article 4056
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SARS-CoV-2-specific immunoglobulin Y antibodies are protective in infected mice
Author / Creator:El-Kafrawy, Sherif A ; Odle, Abby ; Abbas, Aymn T ; Hassan, Ahmed M ; Abdel-Dayem, Umama A ; Qureshi, Arooj K ; Wong, Lok-Yin Roy ; Zheng, Jian ; Meyerholz, David K ; Perlman, Stanley ; Zumla, Alimuddin ; Azhar, Esam I
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2022-09, Vol.18 (9), p.e1010782
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ArticlesPeer ReviewedFull Text
Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS...
Author / Creator:Kibler, Karen V. ; Szczerba, Mateusz ; Lake, Douglas ; Roeder, Alexa J. ; Rahman, Masmudur ; Hogue, Brenda G. ; Roy Wong, Lok-Yin ; Perlman, Stanley ; Li, Yize ; Jacobs, Bertram L.
Publisher:Basel: MDPI AG
Journal title:Vaccines (Basel), 2022-07, Vol.10 (8), p.1172
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ArticlesPeer ReviewedFull Text
Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3
Author / Creator:Lui, Pak-Yin ; Wong, Lok-Yin Roy ; Fung, Cheuk-Lai ; Siu, Kam-Leung ; Yeung, Man-Lung ; Yuen, Kit-San ; Chan, Chi-Ping ; Woo, Patrick Chiu-Yat ; Yuen, Kwok-Yung ; Jin, Dong-Yan
Publisher:United States: Taylor & Francis Ltd
Journal title:Emerging microbes & infections, 2016-04, Vol.5 (1), p.e39-9
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Intranasal immunization with a vaccinia virus vaccine vector expressing pre-fusion stabilized SARS-CoV-2 spike fully protected mice against lethal challenge with the heavily mutated mouse-adapted SARS...
Author / Creator:Kibler, Karen V ; Szczerba, Mateusz ; Lake, Douglas F ; Roeder, Alexa J ; Rahman, Masmudur ; Hogue, Brenda G ; Lok Yin Roy Wong ; Perlman, Stanley ; Li, Yize ; Jacobs, Bertram L
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2021-12
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ArticlesPeer ReviewedFull Text
Proviral role of caspase-6 in coronavirus infections
Author / Creator:Wong, Lok-Yin Roy ; Perlman, Stanley
Publisher:Singapore: Springer Nature Singapore
Journal title:Cell research, 2023-01, Vol.33 (1), p.7-8
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ArticlesFull Text
Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning
Author / Creator:Lei, Ruipeng ; Enya Qing ; Odle, Abby ; Meng Yuan ; Tan, Timothy Jc ; So, Natalie ; Ouyang, Wenhao O ; Wilson, Ian A ; Gallagher, Tom ; Perlman, Stanley ; Wu, Nicholas C ; Lok Yin Roy Wong
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2023-11
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ArticlesPeer ReviewedFull Text
Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19
Author / Creator:Wong, Lok-Yin Roy ; Zheng, Jian ; Wilhelmsen, Kevin ; Li, Kun ; Ortiz, Miguel E. ; Schnicker, Nicholas J. ; Thurman, Andrew ; Pezzulo, Alejandro A. ; Szachowicz, Peter J. ; Li, Pengfei ; Pan, Ruangang ; Klumpp, Klaus ; Aswad, Fred ; Rebo, Justin ; Narumiya, Shuh ; Murakami, Makoto ; Zuniga, Sonia ; Sola, Isabel ; Enjuanes, Luis ; Meyerholz, David K. ; Fortney, Kristen ; McCray, Paul B. ; Perlman, Stanley
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2022-05, Vol.605 (7908), p.146-151
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ArticlesPeer ReviewedFull Text
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection
Author / Creator:Dampalla, Chamandi S. ; Zheng, Jian ; Perera, Krishani Dinali ; Wong, Lok-Yin Roy ; Meyerholz, David K. ; Nguyen, Harry Nhat ; Kashipathy, Maithri M. ; Battaile, Kevin P. ; Lovell, Scott ; Kim, Yunjeong ; Perlman, Stanley ; Groutas, William C. ; Chang, Kyeong-Ok
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (29), p.1-8
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ArticlesPeer ReviewedFull Text
Middle East respiratory syndrome coronavirus Spike protein variants exhibit geographic differences in virulence
Author / Creator:Wong, Lok-Yin Roy ; Zheng, Jian ; Sariol, Alan ; Lowery, Shea ; Meyerholz, David K. ; Gallagher, Tom ; Perlman, Stanley
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-06, Vol.118 (24), p.1-10
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ArticlesPeer ReviewedFull Text
Coronavirus-specific antibody production in middle-aged mice requires phospholipase [A.sub.2]G2D
Author / Creator:Zheng, Jian ; Meyerholz, David ; Wong, Lok-Yin Roy ; Gelb, Michael ; Murakami, Makoto ; Perlman, Stanley
Publisher:American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2021-06, Vol.131 (11)
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ArticlesPeer ReviewedFull Text
SARS-CoV-2-specific immunoglobulin Y antibodies are protective in infected mice
Author / Creator:Sherif A El-Kafrawy ; Abby Odle ; Aymn T Abbas ; Ahmed M Hassan ; Umama A Abdel-Dayem ; Arooj K Qureshi ; Lok-Yin Roy Wong ; Jian Zheng ; David K Meyerholz ; Stanley Perlman ; Alimuddin Zumla ; Esam I Azhar
Publisher:Public Library of Science (PLoS)
Journal title:PLoS pathogens, 2022-09, Vol.18 (9), p.e1010782
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ArticlesFull Text
Post-infection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection
Author / Creator:Dampalla, Chamandi S ; Zhang, Jian ; Perera, Krishani Dinali ; Lok-Yin Roy Wong ; Meyerholz, David K ; Nguyen, Harry Nhat ; Kashipathy, Maithri M ; Battaile, Kevin P ; Lovell, Scott ; Kim, Yunjeong ; Perlman, Stanley ; Groutas, William C ; Chang, Kyeong-Ok
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2021-02
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ArticlesPeer ReviewedFull Text
Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS...
Author / Creator:Kibler, Karen V ; Szczerba, Mateusz ; Lake, Douglas ; Roeder, Alexa J ; Rahman, Masmudur ; Hogue, Brenda G ; Roy Wong, Lok-Yin ; Perlman, Stanley ; Li, Yize ; Jacobs, Bertram L
Publisher:Switzerland
Journal title:Vaccines (Basel), 2022-07, Vol.10 (8)
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Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?

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Author Correction: Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?

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COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice

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SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

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Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D

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Omicron subvariant BA.5 efficiently infects lung cells

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Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning

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SARS-CoV-2-specific immunoglobulin Y antibodies are protective in infected mice

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Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS...

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Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3

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Intranasal immunization with a vaccinia virus vaccine vector expressing pre-fusion stabilized SARS-CoV-2 spike fully protected mice against lethal challenge with the heavily mutated mouse-adapted SARS...

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Proviral role of caspase-6 in coronavirus infections

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Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning

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Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

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Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

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Middle East respiratory syndrome coronavirus Spike protein variants exhibit geographic differences in virulence

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Coronavirus-specific antibody production in middle-aged mice requires phospholipase [A.sub.2]G2D

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SARS-CoV-2-specific immunoglobulin Y antibodies are protective in infected mice

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Post-infection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

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Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS...

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