Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting primin...
Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells
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England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Antigen uptake by dendritic cells and intracellular routing of antigens to specific compartments is regulated by C-type lectin receptors that recognize glycan structures. We show that the modification of Ovalbumin (OVA) with the glycan-structure Lewis(X) (Le(X)) re-directs OVA to the C-type lectin receptor MGL1. Le(X)-modification of OVA favored Th...
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Full title
Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells
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TN_cdi_doaj_primary_oai_doaj_org_article_cc9b1971689946e283d4223a0cc25784
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cc9b1971689946e283d4223a0cc25784
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.11765
