New spiro-indeno[1,2- b ]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for hal...
New spiro-indeno[1,2- b ]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insights
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Publisher
England: Taylor & Francis Ltd
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Language
English
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Publisher
England: Taylor & Francis Ltd
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Contents
Despite the crucial role of CDK2 in tumorigenesis, few inhibitors reached clinical trials for managing lung cancer, the leading cause of cancer death. Herein, we report combinatorial stereoselective synthesis of rationally designed spiroindeno[1,2-
]quinoxaline-based CDK2 inhibitors for NSCLC therapy. The design relied on merging pharmacophoric...
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Full title
New spiro-indeno[1,2- b ]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insights
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TN_cdi_doaj_primary_oai_doaj_org_article_ce8cbb620b7c4ea4995687ba3b35df5e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ce8cbb620b7c4ea4995687ba3b35df5e
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ISSN
1475-6366
E-ISSN
1475-6374
DOI
10.1080/14756366.2023.2281260
