Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Senescence is a state of stable proliferative arrest, generally accompanied by the senescence-associated secretory phenotype, which modulates tissue homeostasis. Enhancer-promoter interactions, facilitated by chromatin loops, play a key role in gene regulation but their relevance in senescence remains elusive. Here, we use Hi-C to show that oncogen...
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Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
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TN_cdi_doaj_primary_oai_doaj_org_article_cfcc6e6ce1f94a00978bd38e7e46977b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_cfcc6e6ce1f94a00978bd38e7e46977b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19878-4
