Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early...
Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission
About this item
Full title
Author / Creator
Muth, Doreen , Corman, Victor Max , Roth, Hanna , Binger, Tabea , Dijkman, Ronald , Gottula, Lina Theresa , Gloza-Rausch, Florian , Balboni, Andrea , Battilani, Mara , Rihtarič, Danijela , Toplak, Ivan , Ameneiros, Ramón Seage , Pfeifer, Alexander , Thiel, Volker , Drexler, Jan Felix , Müller, Marcel Alexander and Drosten, Christian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A 29 nucleotide deletion in open reading frame 8 (ORF8) is the most obvious genetic change in severe acute respiratory syndrome coronavirus (SARS-CoV) during its emergence in humans. In spite of intense study, it remains unclear whether the deletion actually reflects adaptation to humans. Here we engineered full, partially deleted (−29 nt), and ful...
Alternative Titles
Full title
Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission
Authors, Artists and Contributors
Author / Creator
Corman, Victor Max
Roth, Hanna
Binger, Tabea
Dijkman, Ronald
Gottula, Lina Theresa
Gloza-Rausch, Florian
Balboni, Andrea
Battilani, Mara
Rihtarič, Danijela
Toplak, Ivan
Ameneiros, Ramón Seage
Pfeifer, Alexander
Thiel, Volker
Drexler, Jan Felix
Müller, Marcel Alexander
Drosten, Christian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_dc2eb990e1334c749f38f36a60836653
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dc2eb990e1334c749f38f36a60836653
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-33487-8
