Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functiona...
Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens
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Author / Creator
Barbosa, Inês A. M. , Gopalakrishnan, Rajaraman , Mercan, Samuele , Mourikis, Thanos P. , Martin, Typhaine , Wengert, Simon , Sheng, Caibin , Ji, Fei , Lopes, Rui , Knehr, Judith , Altorfer, Marc , Lindeman, Alicia , Russ, Carsten , Naumann, Ulrike , Golji, Javad , Sprouffske, Kathleen , Barys, Louise , Tordella, Luca , Schübeler, Dirk , Schmelzle, Tobias and Galli, Giorgio G.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-function mutations in upstream components of the Hippo pathway, while, in Uveal Melanoma (UM), YAP is activated in a Hippo-independent manner. To date, it is unclear...
Alternative Titles
Full title
Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens
Authors, Artists and Contributors
Author / Creator
Gopalakrishnan, Rajaraman
Mercan, Samuele
Mourikis, Thanos P.
Martin, Typhaine
Wengert, Simon
Sheng, Caibin
Ji, Fei
Lopes, Rui
Knehr, Judith
Altorfer, Marc
Lindeman, Alicia
Russ, Carsten
Naumann, Ulrike
Golji, Javad
Sprouffske, Kathleen
Barys, Louise
Tordella, Luca
Schübeler, Dirk
Schmelzle, Tobias
Galli, Giorgio G.
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e2b59d291ce047f9846c8773ccba1759
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e2b59d291ce047f9846c8773ccba1759
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-39527-w
