CRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffo...
CRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffold mutations
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Cell behavior is controlled by complex gene regulatory networks. Although studies have uncovered diverse roles of individual genes, it has been challenging to record or control sequential genetic events in living cells. In this study, we designed two cellular chain reaction systems that enable sequential sgRNA activation in mammalian cells using a...
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CRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffold mutations
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TN_cdi_doaj_primary_oai_doaj_org_article_e60e48ea503548f2a78b8b97e2db5163
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e60e48ea503548f2a78b8b97e2db5163
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-02986-6
